Incidental Mutation 'IGL01015:Apol7a'
| ID |
53999 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Apol7a
|
| Ensembl Gene |
ENSMUSG00000010601 |
| Gene Name |
apolipoprotein L 7a |
| Synonyms |
9130022K13Rik, Apol3 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL01015
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
15 |
| Chromosomal Location |
77272419-77283310 bp(-) (GRCm39) |
| Type of Mutation |
unclassified |
| DNA Base Change (assembly) |
T to C
at 77274055 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135369
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000010745]
[ENSMUST00000175789]
[ENSMUST00000175919]
[ENSMUST00000176074]
|
| AlphaFold |
B2RT54 |
| Predicted Effect |
unknown
Transcript: ENSMUST00000010745
AA Change: T136A
|
| SMART Domains |
Protein: ENSMUSP00000010745
Gene: ENSMUSG00000010601
AA Change: T136A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ApoL
|
20 |
82 |
2.4e-13 |
PFAM |
|
low complexity region
|
84 |
95 |
N/A |
INTRINSIC |
|
Pfam:ApoL
|
123 |
416 |
1.8e-122 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175789
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000175919
AA Change: T136A
|
| SMART Domains |
Protein: ENSMUSP00000135864
Gene: ENSMUSG00000010601
AA Change: T136A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ApoL
|
20 |
416 |
3.1e-138 |
PFAM |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000176074
AA Change: T136A
|
| SMART Domains |
Protein: ENSMUSP00000134864
Gene: ENSMUSG00000010601
AA Change: T136A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ApoL
|
20 |
416 |
3.1e-138 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176779
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000177135
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 30 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ano4 |
A |
G |
10: 88,870,961 (GRCm39) |
Y238H |
probably damaging |
Het |
| Cacna1d |
A |
T |
14: 29,773,699 (GRCm39) |
|
probably benign |
Het |
| Col12a1 |
A |
G |
9: 79,541,023 (GRCm39) |
V2368A |
probably damaging |
Het |
| Creb3l4 |
A |
G |
3: 90,150,138 (GRCm39) |
M1T |
probably null |
Het |
| Dpys |
T |
C |
15: 39,710,045 (GRCm39) |
D128G |
probably damaging |
Het |
| Ero1b |
A |
G |
13: 12,616,623 (GRCm39) |
|
probably null |
Het |
| Fcgbpl1 |
T |
C |
7: 27,854,743 (GRCm39) |
C1790R |
probably damaging |
Het |
| Fcgr4 |
A |
G |
1: 170,853,358 (GRCm39) |
S188G |
possibly damaging |
Het |
| Fry |
A |
G |
5: 150,346,252 (GRCm39) |
D1587G |
probably benign |
Het |
| Gm43638 |
T |
A |
5: 87,634,473 (GRCm39) |
R45* |
probably null |
Het |
| Gm7647 |
T |
A |
5: 95,111,746 (GRCm39) |
C152S |
probably benign |
Het |
| Golga3 |
T |
G |
5: 110,335,583 (GRCm39) |
M299R |
probably benign |
Het |
| Iqub |
A |
T |
6: 24,501,005 (GRCm39) |
|
probably benign |
Het |
| Irak3 |
A |
T |
10: 119,978,695 (GRCm39) |
Y493* |
probably null |
Het |
| Jakmip1 |
G |
T |
5: 37,242,750 (GRCm39) |
E13* |
probably null |
Het |
| Morc3 |
G |
A |
16: 93,659,534 (GRCm39) |
C446Y |
probably damaging |
Het |
| Mroh2b |
G |
A |
15: 4,971,024 (GRCm39) |
D1010N |
probably damaging |
Het |
| Or14c44 |
A |
G |
7: 86,061,998 (GRCm39) |
T184A |
probably damaging |
Het |
| Or2y16 |
T |
A |
11: 49,335,201 (GRCm39) |
N174K |
probably damaging |
Het |
| Or5m9 |
A |
T |
2: 85,876,996 (GRCm39) |
M57L |
possibly damaging |
Het |
| Pkhd1 |
G |
A |
1: 20,593,482 (GRCm39) |
H1544Y |
possibly damaging |
Het |
| Rps2-ps10 |
C |
T |
18: 61,392,896 (GRCm39) |
|
probably benign |
Het |
| Smco1 |
T |
C |
16: 32,092,887 (GRCm39) |
V186A |
probably damaging |
Het |
| Snx1 |
C |
T |
9: 66,001,713 (GRCm39) |
E314K |
possibly damaging |
Het |
| Timd2 |
T |
C |
11: 46,567,170 (GRCm39) |
Y255C |
probably benign |
Het |
| Tnc |
A |
T |
4: 63,935,571 (GRCm39) |
I455K |
probably benign |
Het |
| Tsc22d1 |
A |
G |
14: 76,656,181 (GRCm39) |
I31V |
possibly damaging |
Het |
| Tyk2 |
A |
G |
9: 21,031,996 (GRCm39) |
S360P |
probably benign |
Het |
| Uroc1 |
G |
T |
6: 90,335,883 (GRCm39) |
|
probably benign |
Het |
| Vmn1r122 |
A |
T |
7: 20,867,761 (GRCm39) |
V98E |
probably damaging |
Het |
|
| Other mutations in Apol7a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01408:Apol7a
|
APN |
15 |
77,273,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01702:Apol7a
|
APN |
15 |
77,273,886 (GRCm39) |
splice site |
probably null |
|
|
IGL02215:Apol7a
|
APN |
15 |
77,277,690 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02931:Apol7a
|
APN |
15 |
77,277,650 (GRCm39) |
nonsense |
probably null |
|
|
R0610:Apol7a
|
UTSW |
15 |
77,273,454 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0652:Apol7a
|
UTSW |
15 |
77,274,055 (GRCm39) |
unclassified |
probably benign |
|
|
R1616:Apol7a
|
UTSW |
15 |
77,273,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1756:Apol7a
|
UTSW |
15 |
77,277,671 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3034:Apol7a
|
UTSW |
15 |
77,273,923 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4566:Apol7a
|
UTSW |
15 |
77,273,951 (GRCm39) |
nonsense |
probably null |
|
|
R5059:Apol7a
|
UTSW |
15 |
77,274,012 (GRCm39) |
unclassified |
probably benign |
|
|
R6807:Apol7a
|
UTSW |
15 |
77,277,520 (GRCm39) |
splice site |
probably null |
|
|
R6995:Apol7a
|
UTSW |
15 |
77,274,176 (GRCm39) |
unclassified |
probably benign |
|
|
R7824:Apol7a
|
UTSW |
15 |
77,273,275 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8364:Apol7a
|
UTSW |
15 |
77,273,820 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R8375:Apol7a
|
UTSW |
15 |
77,273,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9396:Apol7a
|
UTSW |
15 |
77,273,925 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R9471:Apol7a
|
UTSW |
15 |
77,273,680 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Posted On |
2013-06-28 |
Incidental Mutation