Mutagenetix > Incidental Mutation

Incidental Mutation 'R6893:Or5b106'

538184

Institutional Source

Beutler Lab

Gene Symbol

Or5b106

Ensembl Gene

ENSMUSG00000057503

Gene Name

olfactory receptor family 5 subfamily B member 106

Synonyms

MOR202-17, GA_x6K02T2RE5P-3473421-3472498, Olfr1459

MMRRC Submission

044987-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.084) question?

Stock #

R6893 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

13123098-13124021 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 13123106 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Alanine at position 306 (S306A)

Ref Sequence

ENSEMBL: ENSMUSP00000150886 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078299] [ENSMUST00000213493]

AlphaFold

Q8VFV9

Predicted Effect

probably benign
Transcript: ENSMUST00000078299
AA Change: S306A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000077414
Gene: ENSMUSG00000057503
AA Change: S306A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	306	8e-50	PFAM
Pfam:7tm_1	39	288	1.5e-20	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213493
AA Change: S306A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Coding Region Coverage

1x: 99.9%
3x: 99.8%
10x: 98.7%
20x: 95.2%

Validation Efficiency

100% (49/49)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam32	T	A	8: 25,368,770 (GRCm39)	D538V	probably damaging	Het
Akap9	T	C	5: 4,011,709 (GRCm39)	I804T	probably benign	Het
Amy1	T	C	3: 113,357,281 (GRCm39)	E186G	probably benign	Het
Best1	A	G	19: 9,974,446 (GRCm39)	Y33H	probably damaging	Het
Cacna1s	C	A	1: 136,005,431 (GRCm39)	N405K	probably benign	Het
Casp7	T	C	19: 56,421,741 (GRCm39)	Y60H	probably damaging	Het
Ccdc61	T	C	7: 18,626,488 (GRCm39)	N367S	possibly damaging	Het
Cnksr3	A	T	10: 7,085,129 (GRCm39)		probably null	Het
Col14a1	A	C	15: 55,308,044 (GRCm39)		probably benign	Het
Cyp3a57	A	T	5: 145,323,784 (GRCm39)	K424*	probably null	Het
Dnai3	T	C	3: 145,786,184 (GRCm39)	E366G	probably damaging	Het
Dpep3	T	C	8: 106,700,474 (GRCm39)	K411E	probably benign	Het
Ebf2	T	A	14: 67,475,008 (GRCm39)	V81E	probably benign	Het
Ehbp1	G	T	11: 21,964,945 (GRCm39)	T1084K	probably damaging	Het
Fastkd2	C	T	1: 63,770,953 (GRCm39)	A103V	possibly damaging	Het
Gtf3c2	T	C	5: 31,323,722 (GRCm39)	K525E	probably benign	Het
Hdac2	A	G	10: 36,873,003 (GRCm39)	E287G	probably damaging	Het
Ifi207	T	A	1: 173,555,208 (GRCm39)	T832S	possibly damaging	Het
Igf1	G	C	10: 87,700,722 (GRCm39)	V49L	probably damaging	Het
Lef1	A	G	3: 130,909,149 (GRCm39)	D55G	possibly damaging	Het
Lipo2	G	T	19: 33,698,407 (GRCm39)	Y323*	probably null	Het
Mettl24	C	T	10: 40,613,794 (GRCm39)	R178C	probably damaging	Het
Naa80	A	G	9: 107,460,225 (GRCm39)	E40G	probably damaging	Het
Ndrg4	C	A	8: 96,433,229 (GRCm39)	C66*	probably null	Het
Nemf	A	G	12: 69,399,110 (GRCm39)	V140A	probably benign	Het
Nid2	T	A	14: 19,839,855 (GRCm39)	F815I	probably benign	Het
Or4c108	A	G	2: 88,804,143 (GRCm39)	F31L	probably benign	Het
Or8b12c	A	C	9: 37,716,141 (GRCm39)	*311C	probably null	Het
Or8b3b	A	T	9: 38,584,355 (GRCm39)	N141K	possibly damaging	Het
Or8k30	A	G	2: 86,339,136 (GRCm39)	E111G	probably damaging	Het
Pcdhga3	T	C	18: 37,809,598 (GRCm39)	S684P	probably benign	Het
Plch1	A	T	3: 63,660,562 (GRCm39)	C352*	probably null	Het
Plscr2	G	A	9: 92,172,757 (GRCm39)	V139I	probably benign	Het
Ppa1	T	A	10: 61,508,182 (GRCm39)	C270S	probably benign	Het
Ryr2	T	A	13: 11,844,540 (GRCm39)	M399L	possibly damaging	Het
Scn3a	A	G	2: 65,356,098 (GRCm39)	V212A	possibly damaging	Het
Serpina3b	A	G	12: 104,099,285 (GRCm39)	K267E	probably benign	Het
Shroom3	A	G	5: 93,090,063 (GRCm39)	T938A	probably damaging	Het
Specc1	A	C	11: 62,023,279 (GRCm39)	S115R	probably benign	Het
Stim2	C	T	5: 54,210,787 (GRCm39)	T74I	probably benign	Het
Sult6b2	T	A	6: 142,750,025 (GRCm39)	D31V	possibly damaging	Het
Tbc1d24	A	T	17: 24,401,492 (GRCm39)	W406R	probably damaging	Het
Tmprss11b	A	G	5: 86,811,245 (GRCm39)		probably null	Het
Trappc9	A	G	15: 72,797,499 (GRCm39)	Y575H	possibly damaging	Het
Trim63	C	T	4: 134,050,412 (GRCm39)	T232M	probably damaging	Het
Ttn	A	T	2: 76,598,180 (GRCm39)	S19578T	probably damaging	Het
Vmn2r111	T	C	17: 22,778,032 (GRCm39)	N549S	possibly damaging	Het
Xpo4	T	A	14: 57,819,767 (GRCm39)	E1139D	probably benign	Het

Other mutations in Or5b106

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01371:Or5b106	APN	19	13,123,192 (GRCm39)	missense	possibly damaging	0.82
IGL01618:Or5b106	APN	19	13,123,614 (GRCm39)	missense	probably benign	0.00
IGL01800:Or5b106	APN	19	13,123,993 (GRCm39)	missense	probably damaging	1.00
IGL02224:Or5b106	APN	19	13,123,120 (GRCm39)	missense	probably damaging	1.00
BB009:Or5b106	UTSW	19	13,123,345 (GRCm39)	missense	probably benign	0.10
BB019:Or5b106	UTSW	19	13,123,345 (GRCm39)	missense	probably benign	0.10
PIT4651001:Or5b106	UTSW	19	13,123,991 (GRCm39)	missense	probably benign	0.02
R0617:Or5b106	UTSW	19	13,123,727 (GRCm39)	missense	probably benign	0.28
R2041:Or5b106	UTSW	19	13,124,041 (GRCm39)	start gained	probably benign
R2878:Or5b106	UTSW	19	13,123,771 (GRCm39)	missense	probably benign	0.38
R3742:Or5b106	UTSW	19	13,123,258 (GRCm39)	missense	probably damaging	0.98
R4905:Or5b106	UTSW	19	13,123,541 (GRCm39)	missense	probably benign	0.07
R4914:Or5b106	UTSW	19	13,123,355 (GRCm39)	missense	possibly damaging	0.64
R4915:Or5b106	UTSW	19	13,123,355 (GRCm39)	missense	possibly damaging	0.64
R4916:Or5b106	UTSW	19	13,123,355 (GRCm39)	missense	possibly damaging	0.64
R4917:Or5b106	UTSW	19	13,123,355 (GRCm39)	missense	possibly damaging	0.64
R4918:Or5b106	UTSW	19	13,123,355 (GRCm39)	missense	possibly damaging	0.64
R5367:Or5b106	UTSW	19	13,123,865 (GRCm39)	missense	probably damaging	0.98
R6242:Or5b106	UTSW	19	13,123,450 (GRCm39)	missense	probably benign	0.05
R6632:Or5b106	UTSW	19	13,123,552 (GRCm39)	missense	probably benign	0.02
R7932:Or5b106	UTSW	19	13,123,345 (GRCm39)	missense	probably benign	0.10
R9572:Or5b106	UTSW	19	13,123,928 (GRCm39)	missense	possibly damaging	0.78
R9730:Or5b106	UTSW	19	13,123,747 (GRCm39)	missense	possibly damaging	0.80

Predicted Primers

PCR Primer
(F):5'- CTTACTCTTCTGAAGATGATGTTAGCC -3'
(R):5'- ATTGTAAAGCTATCTCCACATGTGC -3'

Sequencing Primer
(F):5'- TGTTAGCCAACACACTATTGCAGAG -3'
(R):5'- GTGCCTCACACTTAACAGCTG -3'

Posted On

2018-11-06