Incidental Mutation 'R7042:Or5w12'
ID 547096
Institutional Source Beutler Lab
Gene Symbol Or5w12
Ensembl Gene ENSMUSG00000075153
Gene Name olfactory receptor family 5 subfamily W member 12
Synonyms GA_x6K02T2Q125-49177531-49176599, MOR177-2, Olfr1135
MMRRC Submission 045141-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R7042 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 87501777-87502709 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 87501935 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 259 (Y259N)
Ref Sequence ENSEMBL: ENSMUSP00000150079 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099853] [ENSMUST00000213835]
AlphaFold Q7TR42
Predicted Effect possibly damaging
Transcript: ENSMUST00000099853
AA Change: Y259N

PolyPhen 2 Score 0.896 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000097439
Gene: ENSMUSG00000075153
AA Change: Y259N

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 3e-44 PFAM
Pfam:7tm_1 41 290 1.6e-17 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213835
AA Change: Y259N

PolyPhen 2 Score 0.896 (Sensitivity: 0.82; Specificity: 0.94)
Meta Mutation Damage Score 0.5430 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (54/54)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsbg3 A G 17: 57,192,098 (GRCm39) S554G possibly damaging Het
Adcy7 G T 8: 89,042,378 (GRCm39) R415L probably damaging Het
Aox1 A T 1: 58,141,759 (GRCm39) I1182F probably damaging Het
Ccdc7b T A 8: 129,811,730 (GRCm39) Y147N probably benign Het
Clcnka A G 4: 141,118,691 (GRCm39) I398T probably damaging Het
Cst8 T A 2: 148,641,796 (GRCm39) probably null Het
Dcxr T C 11: 120,617,841 (GRCm39) D45G possibly damaging Het
Dhx38 A T 8: 110,283,617 (GRCm39) M510K possibly damaging Het
Dync2i1 T C 12: 116,218,061 (GRCm39) I182M probably benign Het
Ebf1 T A 11: 44,882,338 (GRCm39) H431Q probably damaging Het
Eml4 T C 17: 83,768,999 (GRCm39) I681T probably damaging Het
Etf1 T C 18: 35,043,219 (GRCm39) N164S probably benign Het
Fmo2 A G 1: 162,708,226 (GRCm39) V303A probably damaging Het
Foxl2 T A 9: 98,837,715 (GRCm39) M1K probably null Het
Gm3404 A T 5: 146,462,969 (GRCm39) E50D probably benign Het
Gpr61 G A 3: 108,058,647 (GRCm39) P5S possibly damaging Het
Hcrtr1 A G 4: 130,024,653 (GRCm39) probably benign Het
Ier3ip1 T A 18: 77,017,828 (GRCm39) F3I possibly damaging Het
Ifi206 G A 1: 173,308,808 (GRCm39) P396L Het
Ifi209 G A 1: 173,470,236 (GRCm39) V275I probably benign Het
Ighv1-69 T C 12: 115,586,909 (GRCm39) S75G probably benign Het
Kcnj3 A T 2: 55,484,877 (GRCm39) H325L possibly damaging Het
Klrk1 A T 6: 129,593,734 (GRCm39) S50T possibly damaging Het
Mfsd4b4 T A 10: 39,768,514 (GRCm39) Y193F probably damaging Het
Nlrp5 A G 7: 23,116,905 (GRCm39) I210V possibly damaging Het
Or4p20 T A 2: 88,253,746 (GRCm39) I208F possibly damaging Het
Or8b3 G T 9: 38,314,196 (GRCm39) G6C probably damaging Het
Or8d23 A G 9: 38,841,622 (GRCm39) S52G possibly damaging Het
Pax6 A T 2: 105,526,718 (GRCm39) H208L probably benign Het
Pgc C A 17: 48,044,745 (GRCm39) Q331K probably benign Het
Phldb1 A G 9: 44,605,721 (GRCm39) S370P probably damaging Het
Pi4k2a T C 19: 42,093,337 (GRCm39) I226T probably benign Het
Pick1 T C 15: 79,132,965 (GRCm39) S342P probably damaging Het
Plscr1 A G 9: 92,153,588 (GRCm39) M312V probably damaging Het
Ppp3cc T G 14: 70,462,468 (GRCm39) K399Q probably benign Het
Qpctl T C 7: 18,880,943 (GRCm39) H163R probably benign Het
Rab11fip5 A G 6: 85,351,110 (GRCm39) V134A possibly damaging Het
Rasal1 T A 5: 120,802,025 (GRCm39) probably null Het
Rem2 T A 14: 54,715,548 (GRCm39) I171N probably damaging Het
Sec22a T A 16: 35,149,885 (GRCm39) I214L probably benign Het
Setbp1 T C 18: 79,130,070 (GRCm39) D54G probably damaging Het
Slc27a2 C T 2: 126,409,700 (GRCm39) A294V probably damaging Het
Slfn14 T A 11: 83,167,430 (GRCm39) D695V probably damaging Het
Smc6 T A 12: 11,359,301 (GRCm39) I975K probably damaging Het
Spice1 T C 16: 44,206,043 (GRCm39) F835L probably benign Het
Tars2 A T 3: 95,658,057 (GRCm39) H222Q probably benign Het
Tmtc2 A T 10: 105,206,477 (GRCm39) F273I probably damaging Het
Ttc39d C A 17: 80,523,891 (GRCm39) D183E probably benign Het
Vasp A G 7: 18,995,946 (GRCm39) S128P probably benign Het
Vcpip1 A G 1: 9,818,378 (GRCm39) S2P unknown Het
Vmn2r98 T C 17: 19,301,184 (GRCm39) Y729H probably benign Het
Wdr18 A T 10: 79,801,944 (GRCm39) D243V probably benign Het
Xirp2 T C 2: 67,343,633 (GRCm39) V1958A probably benign Het
Zfp451 A T 1: 33,816,474 (GRCm39) M492K probably damaging Het
Zfp804b A G 5: 6,820,042 (GRCm39) I1007T probably benign Het
Other mutations in Or5w12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00952:Or5w12 APN 2 87,502,159 (GRCm39) missense probably damaging 0.99
IGL03158:Or5w12 APN 2 87,502,135 (GRCm39) missense probably benign 0.14
R0559:Or5w12 UTSW 2 87,502,244 (GRCm39) missense possibly damaging 0.54
R1288:Or5w12 UTSW 2 87,501,916 (GRCm39) missense probably benign 0.01
R2278:Or5w12 UTSW 2 87,502,289 (GRCm39) missense possibly damaging 0.63
R2304:Or5w12 UTSW 2 87,502,238 (GRCm39) missense probably benign 0.01
R4328:Or5w12 UTSW 2 87,502,008 (GRCm39) missense possibly damaging 0.52
R5094:Or5w12 UTSW 2 87,502,174 (GRCm39) missense possibly damaging 0.90
R6922:Or5w12 UTSW 2 87,501,797 (GRCm39) nonsense probably null
R8824:Or5w12 UTSW 2 87,502,304 (GRCm39) missense possibly damaging 0.90
R8919:Or5w12 UTSW 2 87,502,567 (GRCm39) missense probably damaging 1.00
R9142:Or5w12 UTSW 2 87,502,313 (GRCm39) missense probably benign 0.00
R9394:Or5w12 UTSW 2 87,502,094 (GRCm39) missense probably benign 0.01
R9712:Or5w12 UTSW 2 87,502,105 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- AACAATGAGGGCTTGCTTGTATG -3'
(R):5'- CAGACCAATGAGTTAATCACCTTTG -3'

Sequencing Primer
(F):5'- GGCTGTAAATCAGAGGGT -3'
(R):5'- CACCTTTGTTATTTTTGGGTTCATTG -3'
Posted On 2019-05-13