Incidental Mutation 'R7102:Cadps'
| ID |
550943 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cadps
|
| Ensembl Gene |
ENSMUSG00000054423 |
| Gene Name |
Ca2+-dependent secretion activator |
| Synonyms |
CAPS1 |
| MMRRC Submission |
045194-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7102 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
14 |
| Chromosomal Location |
9646684-10097200 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 12603738 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Arginine
at position 361
(G361R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000064706
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000067491]
[ENSMUST00000112657]
[ENSMUST00000112658]
[ENSMUST00000177814]
[ENSMUST00000224882]
|
| AlphaFold |
Q80TJ1 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000067491
AA Change: G361R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000064706
Gene: ENSMUSG00000054423
AA Change: G361R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
18 |
N/A |
INTRINSIC |
|
low complexity region
|
41 |
75 |
N/A |
INTRINSIC |
|
coiled coil region
|
93 |
121 |
N/A |
INTRINSIC |
|
C2
|
397 |
492 |
1.08e-2 |
SMART |
|
PH
|
520 |
624 |
1.78e-10 |
SMART |
|
low complexity region
|
772 |
783 |
N/A |
INTRINSIC |
|
DUF1041
|
833 |
948 |
6.21e-54 |
SMART |
|
low complexity region
|
1022 |
1045 |
N/A |
INTRINSIC |
|
low complexity region
|
1354 |
1361 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112657
AA Change: G361R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000108276
Gene: ENSMUSG00000054423
AA Change: G361R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
18 |
N/A |
INTRINSIC |
|
low complexity region
|
41 |
75 |
N/A |
INTRINSIC |
|
coiled coil region
|
93 |
121 |
N/A |
INTRINSIC |
|
C2
|
397 |
492 |
1.08e-2 |
SMART |
|
PH
|
520 |
624 |
1.78e-10 |
SMART |
|
low complexity region
|
775 |
786 |
N/A |
INTRINSIC |
|
DUF1041
|
836 |
941 |
3.88e-55 |
SMART |
|
low complexity region
|
1015 |
1038 |
N/A |
INTRINSIC |
|
low complexity region
|
1347 |
1354 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112658
AA Change: G361R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000108277
Gene: ENSMUSG00000054423
AA Change: G361R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
18 |
N/A |
INTRINSIC |
|
low complexity region
|
41 |
75 |
N/A |
INTRINSIC |
|
coiled coil region
|
93 |
121 |
N/A |
INTRINSIC |
|
C2
|
397 |
492 |
1.08e-2 |
SMART |
|
PH
|
520 |
624 |
1.78e-10 |
SMART |
|
low complexity region
|
776 |
787 |
N/A |
INTRINSIC |
|
DUF1041
|
837 |
942 |
3.88e-55 |
SMART |
|
low complexity region
|
1016 |
1039 |
N/A |
INTRINSIC |
|
low complexity region
|
1348 |
1355 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000177814
AA Change: G361R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000136076
Gene: ENSMUSG00000054423
AA Change: G361R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
18 |
N/A |
INTRINSIC |
|
low complexity region
|
41 |
75 |
N/A |
INTRINSIC |
|
coiled coil region
|
93 |
121 |
N/A |
INTRINSIC |
|
C2
|
397 |
492 |
1.08e-2 |
SMART |
|
PH
|
520 |
624 |
1.78e-10 |
SMART |
|
low complexity region
|
777 |
788 |
N/A |
INTRINSIC |
|
DUF1041
|
838 |
943 |
2.75e-55 |
SMART |
|
low complexity region
|
1017 |
1040 |
N/A |
INTRINSIC |
|
low complexity region
|
1349 |
1356 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000224882
AA Change: G361R
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]
PHENOTYPE: Homozygous null mice display neonatal lethality, respiratory failure and abnormal adrenal gland physiology. Adult heterozygous null mice display abnormal adrenal gland physiology that is different from that seen in homozygous neonates. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
A |
T |
11: 9,285,215 (GRCm39) |
H3283L |
probably damaging |
Het |
| Abcb1a |
T |
G |
5: 8,744,072 (GRCm39) |
S233A |
probably benign |
Het |
| Actr10 |
T |
C |
12: 70,999,805 (GRCm39) |
|
probably null |
Het |
| Acvr2b |
C |
T |
9: 119,261,619 (GRCm39) |
A380V |
probably damaging |
Het |
| Adcy5 |
A |
G |
16: 35,119,995 (GRCm39) |
E1168G |
probably damaging |
Het |
| Akap12 |
C |
T |
10: 4,303,226 (GRCm39) |
T117I |
probably damaging |
Het |
| Alox5 |
T |
A |
6: 116,390,429 (GRCm39) |
Y516F |
probably benign |
Het |
| Amigo2 |
T |
C |
15: 97,143,741 (GRCm39) |
N227S |
probably damaging |
Het |
| Anpep |
C |
A |
7: 79,486,061 (GRCm39) |
V554L |
probably benign |
Het |
| Ap5b1 |
T |
A |
19: 5,620,215 (GRCm39) |
V545E |
possibly damaging |
Het |
| Bbs9 |
C |
T |
9: 22,490,849 (GRCm39) |
L326F |
probably damaging |
Het |
| Bltp1 |
T |
G |
3: 36,994,947 (GRCm39) |
Y990D |
probably damaging |
Het |
| Ccdc57 |
C |
A |
11: 120,812,557 (GRCm39) |
E66* |
probably null |
Het |
| Ccr6 |
G |
A |
17: 8,475,019 (GRCm39) |
V75I |
probably benign |
Het |
| Cdk6 |
T |
C |
5: 3,570,709 (GRCm39) |
F300S |
probably damaging |
Het |
| Cenpb |
A |
C |
2: 131,020,799 (GRCm39) |
V333G |
probably damaging |
Het |
| Clca4a |
T |
C |
3: 144,667,670 (GRCm39) |
I434V |
probably benign |
Het |
| Coro2b |
T |
A |
9: 62,328,667 (GRCm39) |
D447V |
possibly damaging |
Het |
| Cpeb3 |
T |
C |
19: 37,152,119 (GRCm39) |
S86G |
probably benign |
Het |
| Cry2 |
C |
A |
2: 92,243,438 (GRCm39) |
A468S |
probably damaging |
Het |
| Csf2rb2 |
T |
C |
15: 78,181,272 (GRCm39) |
Y40C |
probably damaging |
Het |
| Ddx49 |
T |
A |
8: 70,753,726 (GRCm39) |
T48S |
probably damaging |
Het |
| Dennd10 |
T |
A |
19: 60,821,034 (GRCm39) |
M272K |
probably damaging |
Het |
| Dip2c |
A |
G |
13: 9,654,572 (GRCm39) |
T727A |
probably benign |
Het |
| Dnai3 |
A |
T |
3: 145,761,459 (GRCm39) |
S632R |
possibly damaging |
Het |
| Ebf4 |
A |
T |
2: 130,151,651 (GRCm39) |
I183F |
probably benign |
Het |
| Elavl3 |
G |
T |
9: 21,930,025 (GRCm39) |
P293Q |
possibly damaging |
Het |
| Esyt1 |
A |
T |
10: 128,352,105 (GRCm39) |
L768Q |
probably damaging |
Het |
| Fat2 |
G |
A |
11: 55,174,260 (GRCm39) |
P2151L |
probably damaging |
Het |
| Fgfbp3 |
G |
T |
19: 36,896,606 (GRCm39) |
A4E |
possibly damaging |
Het |
| Flg |
T |
A |
3: 93,200,335 (GRCm39) |
V277D |
unknown |
Het |
| Fndc3b |
T |
C |
3: 27,524,383 (GRCm39) |
D459G |
possibly damaging |
Het |
| Fras1 |
A |
G |
5: 96,718,900 (GRCm39) |
Q438R |
probably benign |
Het |
| Glipr1l2 |
A |
T |
10: 111,928,330 (GRCm39) |
|
probably null |
Het |
| Gm7347 |
T |
A |
5: 26,262,382 (GRCm39) |
|
probably null |
Het |
| Grm6 |
G |
A |
11: 50,753,804 (GRCm39) |
V703I |
possibly damaging |
Het |
| Gtf2h1 |
T |
A |
7: 46,468,550 (GRCm39) |
V496E |
probably benign |
Het |
| Ifna12 |
A |
G |
4: 88,521,388 (GRCm39) |
L53P |
probably damaging |
Het |
| Invs |
T |
A |
4: 48,407,674 (GRCm39) |
S550T |
probably benign |
Het |
| Irak2 |
G |
T |
6: 113,663,810 (GRCm39) |
C453F |
probably damaging |
Het |
| Itih2 |
G |
T |
2: 10,110,574 (GRCm39) |
Q506K |
probably benign |
Het |
| Kidins220 |
T |
C |
12: 25,107,662 (GRCm39) |
I1614T |
probably benign |
Het |
| Krtap5-3 |
T |
A |
7: 141,755,992 (GRCm39) |
C276* |
probably null |
Het |
| Lama3 |
T |
A |
18: 12,685,870 (GRCm39) |
M1128K |
possibly damaging |
Het |
| Lhfpl4 |
C |
T |
6: 113,171,106 (GRCm39) |
A27T |
possibly damaging |
Het |
| Lyplal1 |
A |
G |
1: 185,832,524 (GRCm39) |
V77A |
probably damaging |
Het |
| Malrd1 |
A |
T |
2: 16,147,114 (GRCm39) |
E1985D |
unknown |
Het |
| Mlx |
A |
C |
11: 100,979,802 (GRCm39) |
Q161P |
probably benign |
Het |
| Mroh2b |
T |
A |
15: 4,977,485 (GRCm39) |
M1279K |
probably benign |
Het |
| Myh7b |
A |
G |
2: 155,464,119 (GRCm39) |
E540G |
probably damaging |
Het |
| Neb |
T |
A |
2: 52,194,067 (GRCm39) |
D653V |
probably damaging |
Het |
| Nek10 |
T |
A |
14: 14,828,517 (GRCm38) |
L113Q |
probably damaging |
Het |
| Nlrp4c |
T |
A |
7: 6,068,708 (GRCm39) |
L203* |
probably null |
Het |
| Nscme3l |
T |
A |
19: 5,553,623 (GRCm39) |
T53S |
probably benign |
Het |
| Ntpcr |
T |
A |
8: 126,456,794 (GRCm39) |
C5S |
unknown |
Het |
| Nwd1 |
A |
G |
8: 73,421,957 (GRCm39) |
D1001G |
probably damaging |
Het |
| Or12j5 |
T |
A |
7: 140,084,229 (GRCm39) |
T48S |
probably benign |
Het |
| Or14a256 |
C |
T |
7: 86,265,475 (GRCm39) |
C126Y |
probably benign |
Het |
| Or4p22 |
T |
A |
2: 88,317,492 (GRCm39) |
C139S |
probably damaging |
Het |
| Or6c208 |
A |
C |
10: 129,224,036 (GRCm39) |
D178A |
probably damaging |
Het |
| Osbpl3 |
T |
A |
6: 50,297,115 (GRCm39) |
S564C |
probably damaging |
Het |
| Pax6 |
C |
A |
2: 105,522,604 (GRCm39) |
P264T |
probably damaging |
Het |
| Plppr4 |
T |
C |
3: 117,116,832 (GRCm39) |
R342G |
probably damaging |
Het |
| Prg4 |
C |
T |
1: 150,328,005 (GRCm39) |
C220Y |
probably damaging |
Het |
| Prune2 |
T |
A |
19: 17,098,577 (GRCm39) |
D1360E |
probably benign |
Het |
| Ranbp2 |
T |
A |
10: 58,299,772 (GRCm39) |
S469T |
probably damaging |
Het |
| Rbfox1 |
A |
T |
16: 7,187,698 (GRCm39) |
K43N |
probably benign |
Het |
| Rgs22 |
T |
C |
15: 36,122,459 (GRCm39) |
D25G |
probably damaging |
Het |
| Rnf113a2 |
G |
A |
12: 84,464,545 (GRCm39) |
G146S |
probably damaging |
Het |
| Sbpl |
T |
A |
17: 24,173,608 (GRCm39) |
K55* |
probably null |
Het |
| Scel |
G |
A |
14: 103,781,268 (GRCm39) |
W138* |
probably null |
Het |
| Scgb2b19 |
T |
C |
7: 32,979,711 (GRCm39) |
I12V |
probably null |
Het |
| Scn9a |
T |
A |
2: 66,379,359 (GRCm39) |
M358L |
probably damaging |
Het |
| Sdk2 |
C |
A |
11: 113,733,516 (GRCm39) |
E924* |
probably null |
Het |
| Sipa1l3 |
T |
C |
7: 29,048,012 (GRCm39) |
Q1292R |
possibly damaging |
Het |
| Skint4 |
G |
A |
4: 111,975,298 (GRCm39) |
G86D |
probably damaging |
Het |
| Slc28a3 |
C |
T |
13: 58,736,028 (GRCm39) |
V57I |
probably benign |
Het |
| Slc9a4 |
T |
C |
1: 40,662,559 (GRCm39) |
S609P |
probably damaging |
Het |
| Slc9a4 |
C |
T |
1: 40,619,799 (GRCm39) |
P42S |
probably benign |
Het |
| Slitrk1 |
T |
A |
14: 109,150,061 (GRCm39) |
T217S |
probably benign |
Het |
| Spindoc |
C |
T |
19: 7,335,807 (GRCm39) |
R327H |
probably benign |
Het |
| Stk36 |
T |
C |
1: 74,661,382 (GRCm39) |
S470P |
probably benign |
Het |
| Sypl1 |
C |
T |
12: 33,024,254 (GRCm39) |
P196L |
probably benign |
Het |
| Tekt4 |
T |
A |
17: 25,693,718 (GRCm39) |
I285N |
probably damaging |
Het |
| Tgm5 |
T |
A |
2: 120,876,979 (GRCm39) |
I686F |
possibly damaging |
Het |
| Thsd4 |
C |
A |
9: 59,883,587 (GRCm39) |
R933L |
probably damaging |
Het |
| Treml1 |
T |
A |
17: 48,673,700 (GRCm39) |
I237N |
probably damaging |
Het |
| Txndc16 |
T |
C |
14: 45,442,839 (GRCm39) |
I119V |
probably benign |
Het |
| Ubr3 |
C |
A |
2: 69,728,166 (GRCm39) |
N176K |
probably damaging |
Het |
| Vit |
A |
G |
17: 78,932,426 (GRCm39) |
Y511C |
probably damaging |
Het |
| Vwa5b2 |
G |
A |
16: 20,422,984 (GRCm39) |
G994D |
probably benign |
Het |
| Wnk1 |
T |
C |
6: 119,925,268 (GRCm39) |
T1648A |
unknown |
Het |
| Ythdf1 |
G |
A |
2: 180,553,315 (GRCm39) |
T300I |
probably damaging |
Het |
| Zan |
A |
G |
5: 137,452,462 (GRCm39) |
|
probably null |
Het |
| Zbbx |
A |
G |
3: 75,019,401 (GRCm39) |
L103P |
probably benign |
Het |
| Zfp105 |
A |
G |
9: 122,758,869 (GRCm39) |
D180G |
probably damaging |
Het |
| Zfp114 |
T |
A |
7: 23,880,083 (GRCm39) |
L144Q |
possibly damaging |
Het |
| Zfp128 |
T |
C |
7: 12,624,399 (GRCm39) |
C256R |
probably damaging |
Het |
|
| Other mutations in Cadps |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00926:Cadps
|
APN |
14 |
12,491,795 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00990:Cadps
|
APN |
14 |
12,715,374 (GRCm38) |
missense |
possibly damaging |
0.56 |
|
IGL01071:Cadps
|
APN |
14 |
12,509,091 (GRCm38) |
splice site |
probably null |
|
|
IGL01339:Cadps
|
APN |
14 |
12,486,543 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
IGL01518:Cadps
|
APN |
14 |
12,522,352 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01560:Cadps
|
APN |
14 |
12,491,792 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01598:Cadps
|
APN |
14 |
12,522,202 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL01603:Cadps
|
APN |
14 |
12,454,154 (GRCm38) |
splice site |
probably benign |
|
|
IGL01836:Cadps
|
APN |
14 |
12,522,311 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01839:Cadps
|
APN |
14 |
12,467,184 (GRCm38) |
splice site |
probably benign |
|
|
IGL01932:Cadps
|
APN |
14 |
12,373,609 (GRCm38) |
utr 3 prime |
probably benign |
|
|
IGL02172:Cadps
|
APN |
14 |
12,705,681 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02175:Cadps
|
APN |
14 |
12,467,092 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL02212:Cadps
|
APN |
14 |
12,522,345 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL02351:Cadps
|
APN |
14 |
12,597,380 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02358:Cadps
|
APN |
14 |
12,597,380 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02499:Cadps
|
APN |
14 |
12,822,725 (GRCm38) |
nonsense |
probably null |
|
|
IGL02505:Cadps
|
APN |
14 |
12,449,759 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02591:Cadps
|
APN |
14 |
12,473,465 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02592:Cadps
|
APN |
14 |
12,473,465 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02671:Cadps
|
APN |
14 |
12,491,824 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02956:Cadps
|
APN |
14 |
12,418,047 (GRCm38) |
splice site |
probably benign |
|
|
IGL03029:Cadps
|
APN |
14 |
12,376,675 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03216:Cadps
|
APN |
14 |
12,439,944 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03282:Cadps
|
APN |
14 |
12,465,856 (GRCm38) |
splice site |
probably benign |
|
|
turbo
|
UTSW |
14 |
12,491,800 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0241:Cadps
|
UTSW |
14 |
12,376,675 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0241:Cadps
|
UTSW |
14 |
12,376,675 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0420:Cadps
|
UTSW |
14 |
12,491,800 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1180:Cadps
|
UTSW |
14 |
12,457,836 (GRCm38) |
splice site |
probably benign |
|
|
R1398:Cadps
|
UTSW |
14 |
12,449,822 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1678:Cadps
|
UTSW |
14 |
12,517,802 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1792:Cadps
|
UTSW |
14 |
12,449,802 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R1863:Cadps
|
UTSW |
14 |
12,505,796 (GRCm38) |
missense |
probably benign |
0.09 |
|
R1863:Cadps
|
UTSW |
14 |
12,449,802 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R1918:Cadps
|
UTSW |
14 |
12,546,372 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1920:Cadps
|
UTSW |
14 |
12,465,859 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
R1921:Cadps
|
UTSW |
14 |
12,465,859 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
R1922:Cadps
|
UTSW |
14 |
12,465,859 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
R1925:Cadps
|
UTSW |
14 |
12,705,726 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1966:Cadps
|
UTSW |
14 |
12,822,450 (GRCm38) |
nonsense |
probably null |
|
|
R2013:Cadps
|
UTSW |
14 |
12,522,337 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2228:Cadps
|
UTSW |
14 |
12,465,935 (GRCm38) |
missense |
probably benign |
0.05 |
|
R2331:Cadps
|
UTSW |
14 |
12,603,692 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3436:Cadps
|
UTSW |
14 |
12,616,158 (GRCm38) |
splice site |
probably null |
|
|
R3853:Cadps
|
UTSW |
14 |
12,509,090 (GRCm38) |
splice site |
probably benign |
|
|
R3893:Cadps
|
UTSW |
14 |
12,488,883 (GRCm38) |
utr 3 prime |
probably benign |
|
|
R3916:Cadps
|
UTSW |
14 |
12,457,702 (GRCm38) |
missense |
probably benign |
0.00 |
|
R3917:Cadps
|
UTSW |
14 |
12,457,702 (GRCm38) |
missense |
probably benign |
0.00 |
|
R3953:Cadps
|
UTSW |
14 |
12,505,937 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3966:Cadps
|
UTSW |
14 |
12,522,161 (GRCm38) |
splice site |
probably null |
|
|
R4024:Cadps
|
UTSW |
14 |
12,705,539 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4079:Cadps
|
UTSW |
14 |
12,457,702 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4230:Cadps
|
UTSW |
14 |
12,488,987 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4333:Cadps
|
UTSW |
14 |
12,467,031 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4410:Cadps
|
UTSW |
14 |
12,822,323 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4586:Cadps
|
UTSW |
14 |
12,505,808 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4685:Cadps
|
UTSW |
14 |
12,467,139 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R4698:Cadps
|
UTSW |
14 |
12,705,654 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R4855:Cadps
|
UTSW |
14 |
12,822,449 (GRCm38) |
missense |
unknown |
|
|
R4898:Cadps
|
UTSW |
14 |
12,411,588 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R4908:Cadps
|
UTSW |
14 |
12,536,386 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5208:Cadps
|
UTSW |
14 |
12,457,711 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R5297:Cadps
|
UTSW |
14 |
12,822,345 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5328:Cadps
|
UTSW |
14 |
12,457,790 (GRCm38) |
missense |
probably benign |
0.31 |
|
R5408:Cadps
|
UTSW |
14 |
12,705,759 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R5529:Cadps
|
UTSW |
14 |
12,454,285 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5567:Cadps
|
UTSW |
14 |
12,473,497 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R5570:Cadps
|
UTSW |
14 |
12,473,497 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R5727:Cadps
|
UTSW |
14 |
12,486,525 (GRCm38) |
nonsense |
probably null |
|
|
R5812:Cadps
|
UTSW |
14 |
12,376,685 (GRCm38) |
missense |
probably benign |
|
|
R6361:Cadps
|
UTSW |
14 |
12,491,778 (GRCm38) |
nonsense |
probably null |
|
|
R6767:Cadps
|
UTSW |
14 |
12,550,888 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6805:Cadps
|
UTSW |
14 |
12,467,103 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6861:Cadps
|
UTSW |
14 |
12,522,401 (GRCm38) |
nonsense |
probably null |
|
|
R6883:Cadps
|
UTSW |
14 |
12,465,883 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R6887:Cadps
|
UTSW |
14 |
12,505,811 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6997:Cadps
|
UTSW |
14 |
12,505,793 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R7120:Cadps
|
UTSW |
14 |
12,439,919 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7143:Cadps
|
UTSW |
14 |
12,491,838 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7290:Cadps
|
UTSW |
14 |
12,616,099 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7614:Cadps
|
UTSW |
14 |
12,454,260 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7674:Cadps
|
UTSW |
14 |
12,411,581 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7715:Cadps
|
UTSW |
14 |
12,457,762 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7801:Cadps
|
UTSW |
14 |
12,489,476 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7814:Cadps
|
UTSW |
14 |
12,376,706 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7915:Cadps
|
UTSW |
14 |
12,705,544 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R8087:Cadps
|
UTSW |
14 |
12,536,380 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8109:Cadps
|
UTSW |
14 |
12,488,975 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8485:Cadps
|
UTSW |
14 |
12,439,872 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9156:Cadps
|
UTSW |
14 |
12,705,676 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9158:Cadps
|
UTSW |
14 |
12,546,356 (GRCm38) |
missense |
probably benign |
0.10 |
|
R9312:Cadps
|
UTSW |
14 |
12,616,095 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9465:Cadps
|
UTSW |
14 |
12,489,002 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R9519:Cadps
|
UTSW |
14 |
12,546,290 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R9649:Cadps
|
UTSW |
14 |
12,597,418 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9662:Cadps
|
UTSW |
14 |
12,411,567 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9674:Cadps
|
UTSW |
14 |
12,454,291 (GRCm38) |
missense |
probably damaging |
1.00 |
|
X0018:Cadps
|
UTSW |
14 |
12,373,690 (GRCm38) |
missense |
probably damaging |
1.00 |
|
X0028:Cadps
|
UTSW |
14 |
12,467,118 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
Z1088:Cadps
|
UTSW |
14 |
12,467,113 (GRCm38) |
missense |
probably damaging |
0.96 |
|
Z1177:Cadps
|
UTSW |
14 |
12,465,880 (GRCm38) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACATGGGTCTCCTTGGCTATC -3'
(R):5'- AACACACTTCCTTAATGCCAGGG -3'
Sequencing Primer
(F):5'- TGGCTATCTTACCATACCAGTACAC -3'
(R):5'- GTCAAATCTGTCTCTGGTGTGCAAAC -3'
|
| Posted On |
2019-05-15 |
Incidental Mutation