Incidental Mutation 'PIT4418001:Tas2r108'
ID 555578
Institutional Source Beutler Lab
Gene Symbol Tas2r108
Ensembl Gene ENSMUSG00000037140
Gene Name taste receptor, type 2, member 108
Synonyms mt2r8, T2R8, T2R108, T2r8, mGR08
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # PIT4418001 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 40470526-40471419 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 40470614 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 30 (I30K)
Ref Sequence ENSEMBL: ENSMUSP00000044089 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038750] [ENSMUST00000064932]
AlphaFold Q9JKT3
Predicted Effect probably damaging
Transcript: ENSMUST00000038750
AA Change: I30K

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000044089
Gene: ENSMUSG00000037140
AA Change: I30K

DomainStartEndE-ValueType
Pfam:TAS2R 1 297 5e-93 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000064932
SMART Domains Protein: ENSMUSP00000063743
Gene: ENSMUSG00000052850

DomainStartEndE-ValueType
Pfam:TAS2R 18 320 2.5e-91 PFAM
Coding Region Coverage
  • 1x: 93.3%
  • 3x: 90.8%
  • 10x: 84.7%
  • 20x: 71.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abtb1 T C 6: 88,816,630 (GRCm39) Y100C possibly damaging Het
Adamtsl1 T C 4: 86,161,961 (GRCm39) Y365H probably damaging Het
Atad2b A T 12: 5,074,587 (GRCm39) I1049F probably benign Het
Atg9b A T 5: 24,590,513 (GRCm39) S859T possibly damaging Het
Banp G A 8: 122,732,365 (GRCm39) A380T probably damaging Het
Brinp3 C T 1: 146,777,161 (GRCm39) T536I probably damaging Het
Cacna1c T C 6: 118,631,384 (GRCm39) E1155G Het
Capn12 T C 7: 28,585,961 (GRCm39) S270P probably benign Het
Cbs A T 17: 31,834,495 (GRCm39) I498N possibly damaging Het
Cep68 T C 11: 20,189,731 (GRCm39) K427R probably benign Het
Cobl G A 11: 12,206,240 (GRCm39) T545I possibly damaging Het
Cr2 T A 1: 194,839,760 (GRCm39) M556L probably benign Het
Crebbp A G 16: 3,932,689 (GRCm39) S1068P probably benign Het
D2hgdh C T 1: 93,766,590 (GRCm39) H385Y possibly damaging Het
Dennd1b T C 1: 139,008,999 (GRCm39) L159P Het
Dnajb4 A T 3: 151,899,134 (GRCm39) F31I possibly damaging Het
Dnajc16 A G 4: 141,498,260 (GRCm39) F369S probably damaging Het
Dtl A T 1: 191,273,429 (GRCm39) L493H possibly damaging Het
Efcab5 T A 11: 77,022,877 (GRCm39) Q612L possibly damaging Het
Efr3b A T 12: 4,030,490 (GRCm39) L407Q possibly damaging Het
Ehbp1 T A 11: 22,003,494 (GRCm39) Q1085L probably damaging Het
Ell T C 8: 71,034,331 (GRCm39) V199A probably damaging Het
Elmod2 G T 8: 84,048,171 (GRCm39) T97K probably benign Het
Epn3 T C 11: 94,386,956 (GRCm39) E138G probably damaging Het
Esf1 A T 2: 140,001,697 (GRCm39) F383L probably benign Het
Fam193a A T 5: 34,597,879 (GRCm39) T559S probably damaging Het
Galr2 T C 11: 116,174,084 (GRCm39) V238A probably benign Het
Gm3476 T C 14: 6,118,411 (GRCm38) I237M probably benign Het
Gm5160 A T 18: 14,558,339 (GRCm39) I139F probably damaging Het
Gpr15 T C 16: 58,538,313 (GRCm39) T259A probably benign Het
Iffo1 A G 6: 125,126,746 (GRCm39) K293E possibly damaging Het
Ikbip T A 10: 90,932,395 (GRCm39) H346Q probably benign Het
Il4ra G A 7: 125,175,510 (GRCm39) G573S probably benign Het
Ing2 A T 8: 48,122,125 (GRCm39) M141K probably benign Het
Itga6 T C 2: 71,664,414 (GRCm39) S517P probably benign Het
Itprid1 T G 6: 55,945,330 (GRCm39) S684A probably damaging Het
Kcnab1 A G 3: 65,265,741 (GRCm39) E295G probably benign Het
Klhl21 A C 4: 152,099,835 (GRCm39) Y515S possibly damaging Het
Lcn9 A T 2: 25,714,553 (GRCm39) Y139F probably damaging Het
Mcemp1 G T 8: 3,717,052 (GRCm39) L64F probably null Het
Mos T C 4: 3,870,814 (GRCm39) D334G possibly damaging Het
Myo9b T G 8: 71,775,591 (GRCm39) F338V probably damaging Het
Nefl G A 14: 68,323,979 (GRCm39) V406M probably damaging Het
Nfam1 C A 15: 82,885,689 (GRCm39) R181L probably damaging Het
Ntn5 A G 7: 45,335,925 (GRCm39) R119G probably damaging Het
Or12e10 G T 2: 87,640,938 (GRCm39) C258F probably damaging Het
Or5b101 A T 19: 13,005,095 (GRCm39) Y199* probably null Het
Or7a40 T C 16: 16,491,719 (GRCm39) N42S probably damaging Het
Plch2 A T 4: 155,073,960 (GRCm39) V914E probably damaging Het
Ppp1r12c T C 7: 4,504,266 (GRCm39) Q111R probably null Het
Ptchd3 T A 11: 121,732,566 (GRCm39) Y485* probably null Het
Ptchd4 T A 17: 42,813,980 (GRCm39) I627N probably damaging Het
Retnlb T C 16: 48,637,631 (GRCm39) V19A probably benign Het
Rimbp2 T A 5: 128,857,425 (GRCm39) T809S probably benign Het
Sema6c T A 3: 95,077,401 (GRCm39) D404E possibly damaging Het
Slc22a16 C T 10: 40,479,821 (GRCm39) A631V unknown Het
Snai3 A T 8: 123,183,073 (GRCm39) H157Q probably benign Het
Snx15 T C 19: 6,173,961 (GRCm39) Y52C probably damaging Het
Strbp T C 2: 37,535,504 (GRCm39) E68G probably benign Het
Sun1 T A 5: 139,212,343 (GRCm39) D155E probably damaging Het
Susd2 T C 10: 75,474,183 (GRCm39) D627G probably benign Het
Tmc2 T C 2: 130,090,571 (GRCm39) V639A probably damaging Het
Trmt1 T C 8: 85,424,299 (GRCm39) Y445H probably damaging Het
Ttn A T 2: 76,597,554 (GRCm39) N19786K probably damaging Het
Vmn1r79 T G 7: 11,910,766 (GRCm39) V216G probably damaging Het
Wdr64 C A 1: 175,571,160 (GRCm39) Y331* probably null Het
Zfyve28 A T 5: 34,390,721 (GRCm39) V180E probably damaging Het
Zic4 C T 9: 91,261,447 (GRCm39) T234I possibly damaging Het
Other mutations in Tas2r108
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01355:Tas2r108 APN 6 40,470,685 (GRCm39) missense possibly damaging 0.90
IGL01389:Tas2r108 APN 6 40,470,866 (GRCm39) missense possibly damaging 0.89
IGL01603:Tas2r108 APN 6 40,470,720 (GRCm39) missense possibly damaging 0.96
R1562:Tas2r108 UTSW 6 40,471,000 (GRCm39) splice site probably null
R1582:Tas2r108 UTSW 6 40,470,566 (GRCm39) missense probably benign 0.45
R4544:Tas2r108 UTSW 6 40,470,742 (GRCm39) missense probably benign 0.00
R5579:Tas2r108 UTSW 6 40,471,021 (GRCm39) missense probably benign 0.01
R7840:Tas2r108 UTSW 6 40,470,790 (GRCm39) missense possibly damaging 0.76
R9432:Tas2r108 UTSW 6 40,471,121 (GRCm39) missense probably damaging 1.00
X0027:Tas2r108 UTSW 6 40,470,605 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTGCCTCTTAGACCAGAAATG -3'
(R):5'- TTTGCATCCAGAAACTTCCAAC -3'

Sequencing Primer
(F):5'- CTCTTAGACCAGAAATGGTGTTTGCC -3'
(R):5'- GCATCCAGAAACTTCCAACACAATAG -3'
Posted On 2019-06-07