Incidental Mutation 'R0585:Pla2g2d'
ID 55704
Institutional Source Beutler Lab
Gene Symbol Pla2g2d
Ensembl Gene ENSMUSG00000041202
Gene Name phospholipase A2, group IID
Synonyms Splash, mGIID
MMRRC Submission 038775-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0585 (G1)
Quality Score 110
Status Validated
Chromosome 4
Chromosomal Location 138503046-138509357 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 138506704 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Alanine at position 50 (D50A)
Ref Sequence ENSEMBL: ENSMUSP00000101432 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030528] [ENSMUST00000105806]
AlphaFold Q9WVF6
Predicted Effect probably benign
Transcript: ENSMUST00000030528
AA Change: D76A

PolyPhen 2 Score 0.164 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000030528
Gene: ENSMUSG00000041202
AA Change: D76A

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
PA2c 20 138 5.39e-48 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000105806
AA Change: D50A

PolyPhen 2 Score 0.164 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000101432
Gene: ENSMUSG00000041202
AA Change: D50A

DomainStartEndE-ValueType
PA2c 1 112 2.46e-42 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.6%
  • 20x: 95.2%
Validation Efficiency 100% (38/38)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired resolution of hapten-induced contact hypersensitivity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Brdt T G 5: 107,504,748 (GRCm39) probably null Het
Ccdc162 C T 10: 41,462,375 (GRCm39) C1474Y probably benign Het
Ces2e T C 8: 105,656,453 (GRCm39) S228P probably damaging Het
Clca3a1 G T 3: 144,738,386 (GRCm39) H41N probably benign Het
Cyp2c39 A T 19: 39,525,203 (GRCm39) I169F probably benign Het
Cyp2c65 A G 19: 39,057,686 (GRCm39) K107R probably benign Het
Cyp2c67 T A 19: 39,627,138 (GRCm39) N231Y possibly damaging Het
Eps8l3 G C 3: 107,788,513 (GRCm39) D33H probably damaging Het
Evi5 T C 5: 107,961,402 (GRCm39) probably benign Het
Fcho1 T C 8: 72,168,369 (GRCm39) Y218C probably damaging Het
Gm3993 T A 12: 20,122,149 (GRCm39) probably null Het
Gtf2ird1 A C 5: 134,405,796 (GRCm39) L28R probably damaging Het
Hsf4 A G 8: 105,997,663 (GRCm39) D75G probably damaging Het
Iqca1l A G 5: 24,755,721 (GRCm39) V267A probably benign Het
Larp4b A G 13: 9,197,529 (GRCm39) T249A probably damaging Het
Larp4b A G 13: 9,220,737 (GRCm39) D578G probably benign Het
Lyz3 T A 10: 117,074,356 (GRCm39) I44F possibly damaging Het
Matn3 A T 12: 9,011,103 (GRCm39) probably benign Het
Myo10 T A 15: 25,736,541 (GRCm39) Y428N probably damaging Het
Nf1 T A 11: 79,459,527 (GRCm39) D661E probably damaging Het
Nktr A G 9: 121,583,346 (GRCm39) probably benign Het
Npbwr1 G A 1: 5,986,677 (GRCm39) T279I possibly damaging Het
Or52n3 A C 7: 104,530,706 (GRCm39) H264P probably damaging Het
Osmr T C 15: 6,867,274 (GRCm39) I341V probably benign Het
Pan2 T C 10: 128,146,384 (GRCm39) probably null Het
Pknox2 G A 9: 36,821,056 (GRCm39) probably benign Het
Ptprk C T 10: 28,451,664 (GRCm39) L1051F probably damaging Het
Rap1gds1 G A 3: 138,727,633 (GRCm39) T59M probably benign Het
Rps5 T C 7: 12,659,332 (GRCm39) V41A possibly damaging Het
Ryr1 G T 7: 28,735,501 (GRCm39) D4092E probably damaging Het
Spic T C 10: 88,511,905 (GRCm39) Y117C probably damaging Het
Thrap3 A T 4: 126,072,367 (GRCm39) probably null Het
Tlr9 C T 9: 106,102,275 (GRCm39) T522I probably benign Het
Tspan3 A T 9: 56,053,216 (GRCm39) probably benign Het
Ttn T C 2: 76,703,503 (GRCm39) probably benign Het
Zfp773 T A 7: 7,135,574 (GRCm39) I341L probably benign Het
Zmat3 G A 3: 32,415,254 (GRCm39) P19S probably damaging Het
Other mutations in Pla2g2d
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02662:Pla2g2d APN 4 138,506,006 (GRCm39) missense possibly damaging 0.93
R1888:Pla2g2d UTSW 4 138,503,126 (GRCm39) start codon destroyed probably null
R1888:Pla2g2d UTSW 4 138,503,126 (GRCm39) start codon destroyed probably null
R5666:Pla2g2d UTSW 4 138,507,591 (GRCm39) missense probably damaging 1.00
R7842:Pla2g2d UTSW 4 138,506,089 (GRCm39) missense probably damaging 0.99
Z1177:Pla2g2d UTSW 4 138,503,144 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TTGAGAGCCAGCCAGAGAAGTCAC -3'
(R):5'- GCTTGGTCGGACAGATTACAGAGG -3'

Sequencing Primer
(F):5'- ccaagtgtctcaaccccc -3'
(R):5'- CATGGCATTTCAGGGAGGTTAAAC -3'
Posted On 2013-07-11