Incidental Mutation 'R7207:Zfp952'
ID 560728
Institutional Source Beutler Lab
Gene Symbol Zfp952
Ensembl Gene ENSMUSG00000053390
Gene Name zinc finger protein 952
Synonyms C920016K16Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.094) question?
Stock # R7207 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 33212103-33224431 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 33222489 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 323 (Y323H)
Ref Sequence ENSEMBL: ENSMUSP00000084949 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087666] [ENSMUST00000157017]
AlphaFold B0V2W4
Predicted Effect possibly damaging
Transcript: ENSMUST00000087666
AA Change: Y323H

PolyPhen 2 Score 0.931 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000084949
Gene: ENSMUSG00000053390
AA Change: Y323H

DomainStartEndE-ValueType
KRAB 10 73 4.6e-14 SMART
ZnF_C2H2 251 273 3.44e-4 SMART
ZnF_C2H2 279 301 1.28e-3 SMART
ZnF_C2H2 307 329 1.36e-2 SMART
ZnF_C2H2 335 357 2.75e-3 SMART
ZnF_C2H2 363 385 9.44e-2 SMART
ZnF_C2H2 391 413 1.47e-3 SMART
ZnF_C2H2 419 441 2.91e-2 SMART
ZnF_C2H2 447 469 2.57e-3 SMART
ZnF_C2H2 475 497 1.43e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000157017
SMART Domains Protein: ENSMUSP00000123066
Gene: ENSMUSG00000053390

DomainStartEndE-ValueType
Blast:KRAB 1 35 4e-17 BLAST
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
Allele List at MGI

All alleles(2) : Gene trapped(2)

Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 A G 6: 128,527,734 (GRCm39) Y1019H probably benign Het
Adam11 C A 11: 102,662,883 (GRCm39) A212D probably benign Het
Adamts13 C A 2: 26,868,707 (GRCm39) H230Q probably damaging Het
Adgrl3 G A 5: 81,457,874 (GRCm39) M1I probably null Het
Agap1 A T 1: 89,770,821 (GRCm39) H657L possibly damaging Het
Ano3 T C 2: 110,611,768 (GRCm39) D238G probably damaging Het
Atp8b5 A T 4: 43,357,018 (GRCm39) I589F probably damaging Het
Bmp1 C T 14: 70,717,000 (GRCm39) A859T possibly damaging Het
Cdh20 C A 1: 104,921,702 (GRCm39) D666E probably damaging Het
Cep135 T G 5: 76,780,090 (GRCm39) D807E probably benign Het
Cldn13 G A 5: 134,943,766 (GRCm39) H140Y probably benign Het
Cnksr1 G T 4: 133,962,434 (GRCm39) Q155K possibly damaging Het
Col1a1 G A 11: 94,829,352 (GRCm39) R121Q unknown Het
Coro6 G A 11: 77,358,089 (GRCm39) A225T possibly damaging Het
Ctse C A 1: 131,592,112 (GRCm39) T146K possibly damaging Het
Dhrs7b C A 11: 60,746,623 (GRCm39) Y237* probably null Het
Dnah3 A G 7: 119,570,312 (GRCm39) F2303L probably damaging Het
Dsg2 T A 18: 20,734,516 (GRCm39) D831E probably damaging Het
Dst T C 1: 34,202,418 (GRCm39) S575P probably damaging Het
Epg5 T C 18: 77,992,170 (GRCm39) L289P probably damaging Het
Etl4 A G 2: 20,714,387 (GRCm39) N162S probably damaging Het
Fbf1 A T 11: 116,040,300 (GRCm39) Y602N probably benign Het
Fgd4 A T 16: 16,302,420 (GRCm39) M45K probably benign Het
Fryl C T 5: 73,222,438 (GRCm39) V2048I probably benign Het
Gulp1 T C 1: 44,805,292 (GRCm39) V127A possibly damaging Het
H2-DMb1 T A 17: 34,376,490 (GRCm39) I203N probably damaging Het
Harbi1 T C 2: 91,542,790 (GRCm39) S84P probably damaging Het
Hrh2 T C 13: 54,368,266 (GRCm39) S81P possibly damaging Het
Iars1 T C 13: 49,841,791 (GRCm39) probably null Het
Kcnma1 T C 14: 23,359,083 (GRCm39) *1087W probably null Het
Lama5 T A 2: 179,848,877 (GRCm39) N241I probably damaging Het
Lig4 T A 8: 10,022,101 (GRCm39) K560* probably null Het
Lpin3 G T 2: 160,735,923 (GRCm39) E68* probably null Het
Mrtfb A T 16: 13,144,300 (GRCm39) I7L probably benign Het
Msrb3 A T 10: 120,627,305 (GRCm39) probably null Het
Muc5b A G 7: 141,416,602 (GRCm39) T3183A probably benign Het
Mx1 T A 16: 97,253,398 (GRCm39) D342V probably benign Het
Nrap G T 19: 56,333,953 (GRCm39) T1003K probably damaging Het
Or8u10 A G 2: 85,915,159 (GRCm39) S321P possibly damaging Het
Plxna2 C T 1: 194,326,327 (GRCm39) P87L probably damaging Het
Pms2 C T 5: 143,850,452 (GRCm39) T89I probably damaging Het
Ppp1r12c C A 7: 4,492,867 (GRCm39) R203L probably damaging Het
Pramel31 A G 4: 144,088,473 (GRCm39) T90A probably benign Het
Rab44 C T 17: 29,357,013 (GRCm39) Q48* probably null Het
Rgs14 T C 13: 55,531,047 (GRCm39) V417A probably benign Het
Sgms1 T A 19: 32,120,147 (GRCm39) K253M probably null Het
Sidt2 T C 9: 45,856,449 (GRCm39) Y492C probably damaging Het
Slco1a5 G T 6: 142,194,475 (GRCm39) Y389* probably null Het
Slfn14 G A 11: 83,170,214 (GRCm39) Q477* probably null Het
Sorbs3 T C 14: 70,438,934 (GRCm39) K142R probably damaging Het
Sphk1 A T 11: 116,426,590 (GRCm39) D182V probably damaging Het
Srsf9 C G 5: 115,465,481 (GRCm39) Y38* probably null Het
Stk40 A C 4: 126,019,547 (GRCm39) E107A probably damaging Het
Syngr4 T C 7: 45,538,101 (GRCm39) Y89C possibly damaging Het
Tead1 G A 7: 112,441,287 (GRCm39) R109H possibly damaging Het
Thra A G 11: 98,651,802 (GRCm39) Q108R probably damaging Het
Tnni3k G A 3: 154,580,782 (GRCm39) T621I probably damaging Het
Trim3 A C 7: 105,262,583 (GRCm39) V525G possibly damaging Het
Usp49 T C 17: 47,989,802 (GRCm39) V529A probably benign Het
Vill A T 9: 118,900,281 (GRCm39) Q849L possibly damaging Het
Vps36 T A 8: 22,701,623 (GRCm39) S237T probably benign Het
Zar1l A T 5: 150,430,558 (GRCm39) C284* probably null Het
Zfp948 T C 17: 21,808,602 (GRCm39) V598A possibly damaging Het
Other mutations in Zfp952
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01865:Zfp952 APN 17 33,221,791 (GRCm39) missense probably benign 0.00
IGL02560:Zfp952 APN 17 33,221,793 (GRCm39) nonsense probably null
IGL03056:Zfp952 APN 17 33,221,740 (GRCm39) missense probably damaging 0.98
IGL03151:Zfp952 APN 17 33,221,982 (GRCm39) missense probably benign 0.01
0152:Zfp952 UTSW 17 33,222,195 (GRCm39) splice site probably null
R0508:Zfp952 UTSW 17 33,221,979 (GRCm39) missense possibly damaging 0.90
R1936:Zfp952 UTSW 17 33,222,643 (GRCm39) missense possibly damaging 0.71
R3882:Zfp952 UTSW 17 33,220,949 (GRCm39) nonsense probably null
R4560:Zfp952 UTSW 17 33,222,928 (GRCm39) missense probably benign 0.33
R4649:Zfp952 UTSW 17 33,221,899 (GRCm39) missense probably damaging 0.99
R7103:Zfp952 UTSW 17 33,222,606 (GRCm39) missense possibly damaging 0.94
R7209:Zfp952 UTSW 17 33,222,444 (GRCm39) missense possibly damaging 0.71
R7508:Zfp952 UTSW 17 33,222,756 (GRCm39) missense probably benign 0.06
R7699:Zfp952 UTSW 17 33,220,983 (GRCm39) missense possibly damaging 0.53
R8424:Zfp952 UTSW 17 33,222,191 (GRCm39) missense probably benign 0.18
R8445:Zfp952 UTSW 17 33,222,552 (GRCm39) missense possibly damaging 0.78
R8711:Zfp952 UTSW 17 33,222,004 (GRCm39) missense possibly damaging 0.93
R8919:Zfp952 UTSW 17 33,220,628 (GRCm39) missense possibly damaging 0.71
R8970:Zfp952 UTSW 17 33,221,810 (GRCm39) missense probably benign
Z1177:Zfp952 UTSW 17 33,222,078 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GTCTTAATTCTGACCGGTATTGTG -3'
(R):5'- GGCTTCAGTTCTACCCACTGG -3'

Sequencing Primer
(F):5'- GGGAAGGCATTCAGATATTCCTC -3'
(R):5'- CTGGATGAAGGCTTTCCCACAATG -3'
Posted On 2019-06-26