Incidental Mutation 'R0657:Lypd10'
| ID |
62571 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lypd10
|
| Ensembl Gene |
ENSMUSG00000045587 |
| Gene Name |
Ly6/PLAUR domain containing 10 |
| Synonyms |
BC049730 |
| MMRRC Submission |
038842-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.059)
|
| Stock # |
R0657 (G1)
|
| Quality Score |
140 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
24408667-24413960 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 24412872 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 93
(D93E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000145674
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000051714]
[ENSMUST00000205376]
[ENSMUST00000206826]
|
| AlphaFold |
Q810N3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000051714
AA Change: D93E
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000053275
Gene: ENSMUSG00000045587
AA Change: D93E
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:UPAR_LY6
|
141 |
219 |
3.5e-12 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205376
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206826
AA Change: D93E
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 96.6%
- 20x: 91.3%
|
| Validation Efficiency |
97% (58/60) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930503L19Rik |
G |
A |
18: 70,602,553 (GRCm39) |
Q87* |
probably null |
Het |
| Aldh7a1 |
C |
T |
18: 56,670,269 (GRCm39) |
|
probably benign |
Het |
| Bfsp1 |
A |
C |
2: 143,669,570 (GRCm39) |
|
probably benign |
Het |
| Btbd10 |
A |
T |
7: 112,929,085 (GRCm39) |
S230T |
possibly damaging |
Het |
| Chd7 |
T |
C |
4: 8,753,141 (GRCm39) |
V546A |
probably damaging |
Het |
| Defb13 |
T |
C |
8: 22,436,877 (GRCm39) |
|
probably benign |
Het |
| F13a1 |
A |
T |
13: 37,152,079 (GRCm39) |
D237E |
probably damaging |
Het |
| F8 |
T |
C |
X: 74,255,022 (GRCm39) |
Q2124R |
possibly damaging |
Het |
| Hivep2 |
T |
C |
10: 14,007,622 (GRCm39) |
S1407P |
probably benign |
Het |
| Hmgcs2 |
A |
G |
3: 98,198,369 (GRCm39) |
T91A |
probably benign |
Het |
| Huwe1 |
T |
C |
X: 150,702,924 (GRCm39) |
I3463T |
probably benign |
Het |
| Iars1 |
T |
C |
13: 49,855,995 (GRCm39) |
Y289H |
probably damaging |
Het |
| Ints8 |
C |
A |
4: 11,246,097 (GRCm39) |
V190L |
probably benign |
Het |
| Itgb1 |
T |
G |
8: 129,449,335 (GRCm39) |
Y585D |
possibly damaging |
Het |
| Kif14 |
C |
T |
1: 136,396,840 (GRCm39) |
T382I |
probably benign |
Het |
| Me2 |
A |
G |
18: 73,903,744 (GRCm39) |
S575P |
probably benign |
Het |
| Mgat4b |
T |
C |
11: 50,121,908 (GRCm39) |
V143A |
possibly damaging |
Het |
| Mroh2a |
C |
A |
1: 88,183,287 (GRCm39) |
L1292I |
probably damaging |
Het |
| Nek8 |
C |
T |
11: 78,062,033 (GRCm39) |
S237N |
probably benign |
Het |
| Neto1 |
G |
A |
18: 86,479,445 (GRCm39) |
R211Q |
probably benign |
Het |
| Nfatc2ip |
A |
G |
7: 125,990,507 (GRCm39) |
S165P |
probably benign |
Het |
| Or1e34 |
T |
C |
11: 73,778,611 (GRCm39) |
M196V |
probably benign |
Het |
| Or1e34 |
C |
T |
11: 73,778,656 (GRCm39) |
V181I |
probably benign |
Het |
| Patj |
C |
A |
4: 98,555,885 (GRCm39) |
Q297K |
probably damaging |
Het |
| Pde5a |
A |
G |
3: 122,542,107 (GRCm39) |
N199S |
probably damaging |
Het |
| Pip4k2b |
A |
T |
11: 97,613,762 (GRCm39) |
|
probably benign |
Het |
| Ptch1 |
A |
G |
13: 63,661,565 (GRCm39) |
V1054A |
possibly damaging |
Het |
| Slc17a5 |
G |
A |
9: 78,485,956 (GRCm39) |
A43V |
probably damaging |
Het |
| Spata20 |
T |
A |
11: 94,371,435 (GRCm39) |
D643V |
probably damaging |
Het |
| Tars2 |
A |
T |
3: 95,655,869 (GRCm39) |
V289E |
probably benign |
Het |
| Tmem135 |
A |
T |
7: 88,793,890 (GRCm39) |
I384N |
probably damaging |
Het |
| Trip12 |
C |
T |
1: 84,736,771 (GRCm39) |
M816I |
probably benign |
Het |
| Ulk2 |
T |
C |
11: 61,698,880 (GRCm39) |
|
probably benign |
Het |
| Zzef1 |
T |
C |
11: 72,712,677 (GRCm39) |
V199A |
probably benign |
Het |
|
| Other mutations in Lypd10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00847:Lypd10
|
APN |
7 |
24,413,673 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01353:Lypd10
|
APN |
7 |
24,413,662 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01603:Lypd10
|
APN |
7 |
24,411,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03084:Lypd10
|
APN |
7 |
24,413,605 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0453:Lypd10
|
UTSW |
7 |
24,413,712 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0946:Lypd10
|
UTSW |
7 |
24,413,167 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1076:Lypd10
|
UTSW |
7 |
24,413,167 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1081:Lypd10
|
UTSW |
7 |
24,412,967 (GRCm39) |
splice site |
probably null |
|
|
R1926:Lypd10
|
UTSW |
7 |
24,413,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2571:Lypd10
|
UTSW |
7 |
24,412,819 (GRCm39) |
missense |
probably benign |
0.27 |
|
R3014:Lypd10
|
UTSW |
7 |
24,412,821 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3832:Lypd10
|
UTSW |
7 |
24,413,712 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4197:Lypd10
|
UTSW |
7 |
24,413,119 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4705:Lypd10
|
UTSW |
7 |
24,412,934 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5609:Lypd10
|
UTSW |
7 |
24,413,711 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6166:Lypd10
|
UTSW |
7 |
24,413,644 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6385:Lypd10
|
UTSW |
7 |
24,413,535 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7477:Lypd10
|
UTSW |
7 |
24,413,673 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8022:Lypd10
|
UTSW |
7 |
24,413,599 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8169:Lypd10
|
UTSW |
7 |
24,412,000 (GRCm39) |
missense |
probably benign |
0.15 |
|
R8695:Lypd10
|
UTSW |
7 |
24,413,203 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9129:Lypd10
|
UTSW |
7 |
24,413,170 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCTAAGTGGGAGAATCAAGGGACC -3'
(R):5'- AGGAAGCTGCATAGCATTTCGTGTC -3'
Sequencing Primer
(F):5'- CCAAGAACTGGGCTGTTACC -3'
(R):5'- TGGACTCTGTATTGCAAGAACCC -3'
|
| Posted On |
2013-07-30 |
Incidental Mutation