Incidental Mutation 'IGL01285:Adam6a'
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ID72674
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Adam6a
Ensembl Gene ENSMUSG00000043945
Gene Namea disintegrin and metallopeptidase domain 6A
SynonymsAdam6
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.194) question?
Stock #IGL01285
Quality Score
Status
Chromosome12
Chromosomal Location113543908-113546465 bp(+) (GRCm38)
Type of Mutationmakesense
DNA Base Change (assembly) A to T at 113546273 bp
ZygosityHeterozygous
Amino Acid Change Stop codon to Tyrosine at position 755 (*755Y)
Ref Sequence ENSEMBL: ENSMUSP00000059315 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053086]
Predicted Effect probably null
Transcript: ENSMUST00000053086
AA Change: *755Y
SMART Domains Protein: ENSMUSP00000059315
Gene: ENSMUSG00000043945
AA Change: *755Y

DomainStartEndE-ValueType
Pfam:Pep_M12B_propep 30 167 6.9e-17 PFAM
Pfam:Reprolysin 222 407 4e-15 PFAM
DISIN 427 502 1.63e-33 SMART
ACR 503 640 7.46e-62 SMART
transmembrane domain 704 726 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam5 T C 8: 24,781,594 N599S probably benign Het
Adgrb3 G T 1: 25,093,787 T1166K probably benign Het
Ano1 T C 7: 144,644,742 Y345C probably benign Het
Ano1 A G 7: 144,595,538 V862A probably damaging Het
Asap2 C T 12: 21,229,263 A382V probably damaging Het
Asb18 A G 1: 89,996,241 V100A probably benign Het
Bdnf G A 2: 109,723,586 A102T probably benign Het
Ccser2 G A 14: 36,938,669 T509M probably damaging Het
Des G A 1: 75,362,583 A251T probably benign Het
Dmd C T X: 85,109,984 Q3224* probably null Het
Endog G T 2: 30,171,963 probably null Het
Ggt7 A G 2: 155,500,771 V269A probably damaging Het
Gm17727 A T 9: 35,776,748 N65K possibly damaging Het
Gm7173 A G X: 79,489,158 I767T possibly damaging Het
Gucy2c A G 6: 136,709,741 F808S probably damaging Het
Hira A G 16: 18,912,180 T210A probably benign Het
Ifitm5 C A 7: 140,950,163 R16L probably benign Het
Igdcc4 T C 9: 65,123,991 C404R probably damaging Het
Ints7 G A 1: 191,615,778 R754H probably benign Het
Irf9 A G 14: 55,607,601 E258G probably damaging Het
Megf11 T C 9: 64,660,446 C406R probably damaging Het
Olfml1 A G 7: 107,590,157 N143S possibly damaging Het
Olfr734 A G 14: 50,320,256 F193S possibly damaging Het
Olfr792 T A 10: 129,540,842 F102I probably benign Het
Olfr849 A G 9: 19,440,970 D19G probably benign Het
Otof G T 5: 30,405,183 Q254K probably damaging Het
Plcd3 A G 11: 103,077,870 F332L probably benign Het
Plxnc1 T C 10: 94,799,368 D1332G probably damaging Het
Rnasel A T 1: 153,758,384 D521V probably benign Het
Sema5a T A 15: 32,574,997 V417D possibly damaging Het
Senp6 G A 9: 80,136,718 R877Q probably benign Het
Shroom2 A T X: 152,659,357 D937E probably damaging Het
Slc35a3 A G 3: 116,694,613 S142P probably damaging Het
Srpx A T X: 10,039,059 V398E probably damaging Het
Stk10 A T 11: 32,610,653 K669N possibly damaging Het
Sumf2 A G 5: 129,849,970 D49G probably damaging Het
Syde1 T A 10: 78,588,887 E370D probably damaging Het
Tas2r115 G T 6: 132,737,678 S103R probably damaging Het
Top2a G A 11: 99,006,159 probably benign Het
Ttn T A 2: 76,720,498 T23190S probably damaging Het
Ttyh3 C A 5: 140,629,412 C407F probably damaging Het
Vmn2r27 G T 6: 124,192,411 H587N possibly damaging Het
Vmn2r74 A G 7: 85,957,484 I218T possibly damaging Het
Vsig10 A G 5: 117,324,889 N60S probably benign Het
Zc3h7a A G 16: 11,139,115 S877P probably damaging Het
Zfp979 G T 4: 147,615,396 T29N probably damaging Het
Znfx1 G A 2: 167,038,695 R390C possibly damaging Het
Other mutations in Adam6a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00580:Adam6a APN 12 113545225 missense probably benign 0.00
IGL00896:Adam6a APN 12 113545410 missense possibly damaging 0.56
IGL01146:Adam6a APN 12 113544220 missense probably damaging 1.00
IGL01839:Adam6a APN 12 113544622 missense probably benign 0.03
IGL01906:Adam6a APN 12 113544331 missense probably benign 0.19
IGL02306:Adam6a APN 12 113545723 missense possibly damaging 0.93
IGL03146:Adam6a APN 12 113545524 missense probably damaging 1.00
IGL03176:Adam6a APN 12 113546202 missense probably benign 0.00
IGL03365:Adam6a APN 12 113544145 missense possibly damaging 0.86
IGL03373:Adam6a APN 12 113545552 missense possibly damaging 0.55
R0091:Adam6a UTSW 12 113544229 missense possibly damaging 0.46
R0149:Adam6a UTSW 12 113545749 missense probably damaging 1.00
R0348:Adam6a UTSW 12 113544717 missense probably damaging 0.99
R0376:Adam6a UTSW 12 113544690 missense probably damaging 1.00
R1471:Adam6a UTSW 12 113544393 missense probably damaging 1.00
R1474:Adam6a UTSW 12 113544449 missense possibly damaging 0.66
R1553:Adam6a UTSW 12 113545215 missense probably damaging 1.00
R1679:Adam6a UTSW 12 113544756 missense probably benign 0.00
R1808:Adam6a UTSW 12 113544714 missense probably benign 0.00
R1826:Adam6a UTSW 12 113546122 missense possibly damaging 0.46
R1856:Adam6a UTSW 12 113545303 missense probably damaging 1.00
R1916:Adam6a UTSW 12 113545936 missense probably benign
R2011:Adam6a UTSW 12 113545378 missense probably benign 0.09
R2049:Adam6a UTSW 12 113544429 missense probably benign 0.17
R2364:Adam6a UTSW 12 113544630 missense probably benign 0.05
R3820:Adam6a UTSW 12 113544178 missense probably benign 0.00
R4119:Adam6a UTSW 12 113544574 missense probably benign 0.06
R4540:Adam6a UTSW 12 113544499 missense probably damaging 1.00
R4627:Adam6a UTSW 12 113544949 missense probably benign
R4665:Adam6a UTSW 12 113544372 missense possibly damaging 0.64
R4859:Adam6a UTSW 12 113545989 missense probably damaging 1.00
R4997:Adam6a UTSW 12 113545371 missense probably damaging 1.00
R5270:Adam6a UTSW 12 113544127 missense possibly damaging 0.46
R5751:Adam6a UTSW 12 113544827 missense possibly damaging 0.79
R5775:Adam6a UTSW 12 113546266 missense possibly damaging 0.47
R5863:Adam6a UTSW 12 113544367 missense probably benign 0.01
R6154:Adam6a UTSW 12 113545672 missense probably benign 0.11
R6313:Adam6a UTSW 12 113545050 missense possibly damaging 0.56
R6316:Adam6a UTSW 12 113545576 missense probably benign 0.27
R6706:Adam6a UTSW 12 113545266 missense probably benign 0.00
R6845:Adam6a UTSW 12 113544097 missense possibly damaging 0.96
X0027:Adam6a UTSW 12 113545243 missense probably benign 0.01
Posted On2013-10-07