Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01285:Or6c66b'

72675

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or6c66b

Ensembl Gene

ENSMUSG00000094496

Gene Name

olfactory receptor family 6 subfamily C member 66B

Synonyms

Olfr792, MOR108-2, GA_x6K02T2PULF-11219415-11220350

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

IGL01285

Quality Score

Status

Chromosome

Chromosomal Location

129376408-129377343 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 129376711 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Isoleucine at position 102 (F102I)

Ref Sequence

ENSEMBL: ENSMUSP00000149872 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076575] [ENSMUST00000215436]

AlphaFold

Q7TRH9

Predicted Effect

probably benign
Transcript: ENSMUST00000076575
AA Change: F102I

PolyPhen 2 Score 0.074 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000096707
Gene: ENSMUSG00000094496
AA Change: F102I

Domain	Start	End	E-Value	Type
Pfam:7tm_4	28	306	1.9e-53	PFAM
Pfam:7tm_1	39	288	4.7e-25	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000215436
AA Change: F102I

PolyPhen 2 Score 0.074 (Sensitivity: 0.93; Specificity: 0.85)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam5	T	C	8: 25,271,610 (GRCm39)	N599S	probably benign	Het
Adam6a	A	T	12: 113,509,893 (GRCm39)	*755Y	probably null	Het
Adgrb3	G	T	1: 25,132,868 (GRCm39)	T1166K	probably benign	Het
Ano1	T	C	7: 144,198,479 (GRCm39)	Y345C	probably benign	Het
Ano1	A	G	7: 144,149,275 (GRCm39)	V862A	probably damaging	Het
Asap2	C	T	12: 21,279,264 (GRCm39)	A382V	probably damaging	Het
Asb18	A	G	1: 89,923,963 (GRCm39)	V100A	probably benign	Het
Bdnf	G	A	2: 109,553,931 (GRCm39)	A102T	probably benign	Het
Ccser2	G	A	14: 36,660,626 (GRCm39)	T509M	probably damaging	Het
Cfap47	A	G	X: 78,532,764 (GRCm39)	I767T	possibly damaging	Het
Des	G	A	1: 75,339,227 (GRCm39)	A251T	probably benign	Het
Dmd	C	T	X: 84,153,590 (GRCm39)	Q3224*	probably null	Het
Endog	G	T	2: 30,061,975 (GRCm39)		probably null	Het
Ggt7	A	G	2: 155,342,691 (GRCm39)	V269A	probably damaging	Het
Gucy2c	A	G	6: 136,686,739 (GRCm39)	F808S	probably damaging	Het
Hira	A	G	16: 18,730,930 (GRCm39)	T210A	probably benign	Het
Ifitm5	C	A	7: 140,530,076 (GRCm39)	R16L	probably benign	Het
Igdcc4	T	C	9: 65,031,273 (GRCm39)	C404R	probably damaging	Het
Ints7	G	A	1: 191,347,890 (GRCm39)	R754H	probably benign	Het
Irf9	A	G	14: 55,845,058 (GRCm39)	E258G	probably damaging	Het
Megf11	T	C	9: 64,567,728 (GRCm39)	C406R	probably damaging	Het
Olfml1	A	G	7: 107,189,364 (GRCm39)	N143S	possibly damaging	Het
Or4m1	A	G	14: 50,557,713 (GRCm39)	F193S	possibly damaging	Het
Or7g30	A	G	9: 19,352,266 (GRCm39)	D19G	probably benign	Het
Otof	G	T	5: 30,562,527 (GRCm39)	Q254K	probably damaging	Het
Pate7	A	T	9: 35,688,044 (GRCm39)	N65K	possibly damaging	Het
Plcd3	A	G	11: 102,968,696 (GRCm39)	F332L	probably benign	Het
Plxnc1	T	C	10: 94,635,230 (GRCm39)	D1332G	probably damaging	Het
Rnasel	A	T	1: 153,634,130 (GRCm39)	D521V	probably benign	Het
Sema5a	T	A	15: 32,575,143 (GRCm39)	V417D	possibly damaging	Het
Senp6	G	A	9: 80,044,000 (GRCm39)	R877Q	probably benign	Het
Shroom2	A	T	X: 151,442,353 (GRCm39)	D937E	probably damaging	Het
Slc35a3	A	G	3: 116,488,262 (GRCm39)	S142P	probably damaging	Het
Srpx	A	T	X: 9,905,298 (GRCm39)	V398E	probably damaging	Het
Stk10	A	T	11: 32,560,653 (GRCm39)	K669N	possibly damaging	Het
Sumf2	A	G	5: 129,878,811 (GRCm39)	D49G	probably damaging	Het
Syde1	T	A	10: 78,424,721 (GRCm39)	E370D	probably damaging	Het
Tas2r115	G	T	6: 132,714,641 (GRCm39)	S103R	probably damaging	Het
Top2a	G	A	11: 98,896,985 (GRCm39)		probably benign	Het
Ttn	T	A	2: 76,550,842 (GRCm39)	T23190S	probably damaging	Het
Ttyh3	C	A	5: 140,615,167 (GRCm39)	C407F	probably damaging	Het
Vmn2r27	G	T	6: 124,169,370 (GRCm39)	H587N	possibly damaging	Het
Vmn2r74	A	G	7: 85,606,692 (GRCm39)	I218T	possibly damaging	Het
Vsig10	A	G	5: 117,462,954 (GRCm39)	N60S	probably benign	Het
Zc3h7a	A	G	16: 10,956,979 (GRCm39)	S877P	probably damaging	Het
Zfp979	G	T	4: 147,699,853 (GRCm39)	T29N	probably damaging	Het
Znfx1	G	A	2: 166,880,615 (GRCm39)	R390C	possibly damaging	Het

Other mutations in Or6c66b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01459:Or6c66b	APN	10	129,376,410 (GRCm39)	start codon destroyed	probably null	1.00
IGL02090:Or6c66b	APN	10	129,377,176 (GRCm39)	missense	probably damaging	1.00
IGL03338:Or6c66b	APN	10	129,376,925 (GRCm39)	missense	probably damaging	0.99
R0382:Or6c66b	UTSW	10	129,376,883 (GRCm39)	missense	probably benign	0.01
R1672:Or6c66b	UTSW	10	129,376,561 (GRCm39)	missense	probably benign	0.00
R2285:Or6c66b	UTSW	10	129,376,537 (GRCm39)	missense	probably benign	0.22
R2938:Or6c66b	UTSW	10	129,376,484 (GRCm39)	missense	probably damaging	1.00
R3498:Or6c66b	UTSW	10	129,376,778 (GRCm39)	missense	probably damaging	1.00
R5309:Or6c66b	UTSW	10	129,377,134 (GRCm39)	missense	probably benign	0.01
R5312:Or6c66b	UTSW	10	129,377,134 (GRCm39)	missense	probably benign	0.01
R6004:Or6c66b	UTSW	10	129,376,759 (GRCm39)	missense	probably benign	0.31
R6800:Or6c66b	UTSW	10	129,377,132 (GRCm39)	missense	probably damaging	1.00
R7127:Or6c66b	UTSW	10	129,376,936 (GRCm39)	missense	probably damaging	1.00
R7167:Or6c66b	UTSW	10	129,376,607 (GRCm39)	missense	possibly damaging	0.88
R7763:Or6c66b	UTSW	10	129,377,324 (GRCm39)	missense	probably benign
R7819:Or6c66b	UTSW	10	129,376,562 (GRCm39)	missense	probably benign	0.01
R8104:Or6c66b	UTSW	10	129,376,826 (GRCm39)	missense	probably benign
R8189:Or6c66b	UTSW	10	129,377,122 (GRCm39)	missense	probably damaging	0.99
R8672:Or6c66b	UTSW	10	129,376,596 (GRCm39)	missense	probably damaging	0.99
Z1189:Or6c66b	UTSW	10	129,377,246 (GRCm39)	missense	probably benign	0.44

Posted On

2013-10-07