Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01346:Vmn2r120'

75038

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r120

Ensembl Gene

ENSMUSG00000090655

Gene Name

vomeronasal 2, receptor 120

Synonyms

EG224916

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

IGL01346

Quality Score

Status

Chromosome

Chromosomal Location

57815783-57852314 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 57852232 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Valine at position 28 (G28V)

Ref Sequence

ENSEMBL: ENSMUSP00000129296 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165781]

AlphaFold

A0A3Q4EG79

Predicted Effect

probably benign
Transcript: ENSMUST00000165781
AA Change: G28V

PolyPhen 2 Score 0.110 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000129296
Gene: ENSMUSG00000090655
AA Change: G28V

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	80	474	5.9e-42	PFAM
Pfam:NCD3G	517	570	7.5e-22	PFAM
Pfam:7tm_3	598	836	1.3e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3300002I08Rik	A	G	2: 150,152,980 (GRCm39)	V135A	unknown	Het
Cnot4	A	T	6: 35,047,183 (GRCm39)	I143N	probably damaging	Het
Cnot6l	A	T	5: 96,234,105 (GRCm39)	M302K	probably damaging	Het
Dmxl2	T	C	9: 54,322,759 (GRCm39)	T1542A	probably damaging	Het
Dnaaf9	A	G	2: 130,633,766 (GRCm39)		probably benign	Het
Dnhd1	T	C	7: 105,363,116 (GRCm39)	S3893P	probably benign	Het
Duox2	A	T	2: 122,117,683 (GRCm39)		probably benign	Het
Dusp1	T	C	17: 26,725,295 (GRCm39)	N355D	probably benign	Het
Fam76b	T	C	9: 13,741,046 (GRCm39)	C60R	probably damaging	Het
Gnptab	G	A	10: 88,272,041 (GRCm39)	V944I	possibly damaging	Het
Gys1	A	G	7: 45,091,961 (GRCm39)	Y249C	probably damaging	Het
Ift88	A	T	14: 57,681,862 (GRCm39)	E215D	probably damaging	Het
Kcnu1	T	C	8: 26,424,551 (GRCm39)		probably benign	Het
Lmln	C	A	16: 32,937,490 (GRCm39)	N618K	probably benign	Het
Lrrc75a	T	C	11: 62,496,813 (GRCm39)	T250A	probably damaging	Het
Mpp4	A	G	1: 59,164,719 (GRCm39)	S435P	probably damaging	Het
Myo1c	T	A	11: 75,563,076 (GRCm39)	V1036E	probably damaging	Het
Nlrp12	T	G	7: 3,289,316 (GRCm39)	T399P	probably damaging	Het
Or2y16	A	G	11: 49,335,595 (GRCm39)	R306G	probably benign	Het
Or4c118	A	G	2: 88,974,575 (GRCm39)	F264S	possibly damaging	Het
Parp8	A	T	13: 117,031,600 (GRCm39)	C332S	possibly damaging	Het
Pdcd11	G	A	19: 47,098,053 (GRCm39)	V780I	probably benign	Het
Plekha5	A	G	6: 140,480,292 (GRCm39)		probably benign	Het
Ppt1	T	A	4: 122,737,848 (GRCm39)	I62K	probably damaging	Het
Proser3	T	C	7: 30,249,071 (GRCm39)	N7S	probably benign	Het
Ptk2b	A	G	14: 66,414,567 (GRCm39)	L311P	possibly damaging	Het
Rasal2	T	C	1: 156,988,786 (GRCm39)	N706S	probably benign	Het
Ripk2	A	G	4: 16,132,775 (GRCm39)		probably null	Het
Setx	T	A	2: 29,034,821 (GRCm39)	H435Q	probably damaging	Het
Smurf2	T	A	11: 106,721,741 (GRCm39)		probably benign	Het
Snx32	A	G	19: 5,547,764 (GRCm39)	L182P	possibly damaging	Het
Stpg2	A	G	3: 139,125,635 (GRCm39)		probably benign	Het
Taar2	A	G	10: 23,816,997 (GRCm39)	Y179C	probably damaging	Het
Tenm2	G	A	11: 35,918,232 (GRCm39)	R1843*	probably null	Het
Tmco4	T	C	4: 138,748,260 (GRCm39)	I280T	probably damaging	Het
Tuba4a	C	A	1: 75,193,921 (GRCm39)	C46F	probably damaging	Het
Ubr1	A	G	2: 120,703,603 (GRCm39)		probably null	Het
Vldlr	A	T	19: 27,217,081 (GRCm39)	I45L	possibly damaging	Het
Vmn2r37	C	A	7: 9,209,680 (GRCm39)	V611L	probably benign	Het
Vmn2r67	A	G	7: 84,786,127 (GRCm39)	L626P	probably damaging	Het
Wdr19	C	T	5: 65,379,082 (GRCm39)		probably benign	Het
Zfp595	T	A	13: 67,464,749 (GRCm39)	K505*	probably null	Het

Other mutations in Vmn2r120

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01335:Vmn2r120	APN	17	57,832,732 (GRCm39)	missense	possibly damaging	0.86
IGL01996:Vmn2r120	APN	17	57,832,222 (GRCm39)	missense	possibly damaging	0.92
IGL02503:Vmn2r120	APN	17	57,816,385 (GRCm39)	missense	probably benign	0.40
IGL02582:Vmn2r120	APN	17	57,831,724 (GRCm39)	missense	probably damaging	0.99
IGL02747:Vmn2r120	APN	17	57,831,719 (GRCm39)	missense	probably benign	0.19
IGL02896:Vmn2r120	APN	17	57,816,008 (GRCm39)	missense	probably damaging	1.00
IGL03139:Vmn2r120	APN	17	57,831,742 (GRCm39)	missense	probably benign	0.39
IGL03342:Vmn2r120	APN	17	57,816,372 (GRCm39)	missense	probably benign	0.03
A4554:Vmn2r120	UTSW	17	57,832,715 (GRCm39)	missense	probably benign	0.01
R0207:Vmn2r120	UTSW	17	57,832,052 (GRCm39)	missense	probably benign	0.17
R0472:Vmn2r120	UTSW	17	57,831,518 (GRCm39)	missense	probably benign	0.03
R0517:Vmn2r120	UTSW	17	57,815,949 (GRCm39)	missense	probably damaging	1.00
R1109:Vmn2r120	UTSW	17	57,832,829 (GRCm39)	missense	probably benign	0.09
R1316:Vmn2r120	UTSW	17	57,832,939 (GRCm39)	missense	probably benign	0.28
R1543:Vmn2r120	UTSW	17	57,829,374 (GRCm39)	missense	probably benign	0.09
R1795:Vmn2r120	UTSW	17	57,832,038 (GRCm39)	missense	probably benign	0.35
R1850:Vmn2r120	UTSW	17	57,832,826 (GRCm39)	missense	probably benign	0.19
R1920:Vmn2r120	UTSW	17	57,831,839 (GRCm39)	missense	probably benign	0.01
R1921:Vmn2r120	UTSW	17	57,831,839 (GRCm39)	missense	probably benign	0.01
R1922:Vmn2r120	UTSW	17	57,831,839 (GRCm39)	missense	probably benign	0.01
R2063:Vmn2r120	UTSW	17	57,831,553 (GRCm39)	missense	possibly damaging	0.88
R2064:Vmn2r120	UTSW	17	57,831,553 (GRCm39)	missense	possibly damaging	0.88
R2065:Vmn2r120	UTSW	17	57,831,553 (GRCm39)	missense	possibly damaging	0.88
R2067:Vmn2r120	UTSW	17	57,831,553 (GRCm39)	missense	possibly damaging	0.88
R2286:Vmn2r120	UTSW	17	57,815,958 (GRCm39)	missense	probably damaging	1.00
R2291:Vmn2r120	UTSW	17	57,816,479 (GRCm39)	missense	probably damaging	1.00
R3416:Vmn2r120	UTSW	17	57,816,241 (GRCm39)	missense	possibly damaging	0.89
R3874:Vmn2r120	UTSW	17	57,831,954 (GRCm39)	missense	probably benign	0.40
R4023:Vmn2r120	UTSW	17	57,843,718 (GRCm39)	missense	possibly damaging	0.92
R4024:Vmn2r120	UTSW	17	57,843,718 (GRCm39)	missense	possibly damaging	0.92
R4348:Vmn2r120	UTSW	17	57,829,466 (GRCm39)	missense	possibly damaging	0.47
R4409:Vmn2r120	UTSW	17	57,816,477 (GRCm39)	missense	probably damaging	1.00
R4610:Vmn2r120	UTSW	17	57,816,120 (GRCm39)	missense	probably damaging	1.00
R4771:Vmn2r120	UTSW	17	57,831,887 (GRCm39)	missense	probably damaging	1.00
R4786:Vmn2r120	UTSW	17	57,829,048 (GRCm39)	missense	probably benign	0.14
R4927:Vmn2r120	UTSW	17	57,816,125 (GRCm39)	missense	probably damaging	1.00
R5285:Vmn2r120	UTSW	17	57,843,703 (GRCm39)	missense	probably damaging	1.00
R5566:Vmn2r120	UTSW	17	57,852,290 (GRCm39)	missense	possibly damaging	0.95
R5578:Vmn2r120	UTSW	17	57,829,514 (GRCm39)	missense	probably benign	0.01
R5643:Vmn2r120	UTSW	17	57,831,977 (GRCm39)	missense	probably benign	0.01
R5644:Vmn2r120	UTSW	17	57,831,977 (GRCm39)	missense	probably benign	0.01
R5781:Vmn2r120	UTSW	17	57,831,938 (GRCm39)	missense	probably benign	0.00
R6084:Vmn2r120	UTSW	17	57,832,721 (GRCm39)	missense	probably benign	0.15
R6120:Vmn2r120	UTSW	17	57,832,973 (GRCm39)	missense	probably benign	0.02
R6160:Vmn2r120	UTSW	17	57,816,418 (GRCm39)	missense	probably benign	0.03
R6248:Vmn2r120	UTSW	17	57,852,287 (GRCm39)	missense	probably benign	0.03
R6256:Vmn2r120	UTSW	17	57,831,700 (GRCm39)	nonsense	probably null
R6730:Vmn2r120	UTSW	17	57,832,012 (GRCm39)	missense	probably benign	0.03
R6821:Vmn2r120	UTSW	17	57,843,659 (GRCm39)	missense	probably benign	0.00
R6868:Vmn2r120	UTSW	17	57,852,218 (GRCm39)	missense	probably benign	0.00
R6880:Vmn2r120	UTSW	17	57,816,187 (GRCm39)	missense	probably damaging	1.00
R6986:Vmn2r120	UTSW	17	57,816,340 (GRCm39)	missense	probably damaging	1.00
R7276:Vmn2r120	UTSW	17	57,831,881 (GRCm39)	missense	probably benign	0.11
R7373:Vmn2r120	UTSW	17	57,816,406 (GRCm39)	missense	probably benign	0.35
R7653:Vmn2r120	UTSW	17	57,816,258 (GRCm39)	missense	possibly damaging	0.93
R7667:Vmn2r120	UTSW	17	57,843,657 (GRCm39)	missense	probably benign	0.04
R7775:Vmn2r120	UTSW	17	57,832,942 (GRCm39)	missense	probably damaging	1.00
R7778:Vmn2r120	UTSW	17	57,832,942 (GRCm39)	missense	probably damaging	1.00
R7797:Vmn2r120	UTSW	17	57,815,874 (GRCm39)	missense	probably damaging	1.00
R7824:Vmn2r120	UTSW	17	57,832,942 (GRCm39)	missense	probably damaging	1.00
R7902:Vmn2r120	UTSW	17	57,816,244 (GRCm39)	missense	possibly damaging	0.87
R7922:Vmn2r120	UTSW	17	57,831,683 (GRCm39)	missense	probably damaging	0.99
R8508:Vmn2r120	UTSW	17	57,832,843 (GRCm39)	missense	probably benign	0.03
R8847:Vmn2r120	UTSW	17	57,816,217 (GRCm39)	missense	probably benign	0.01
R8882:Vmn2r120	UTSW	17	57,852,229 (GRCm39)	missense	probably benign	0.01
R9134:Vmn2r120	UTSW	17	57,832,093 (GRCm39)	missense	probably damaging	1.00
R9161:Vmn2r120	UTSW	17	57,831,864 (GRCm39)	missense
R9336:Vmn2r120	UTSW	17	57,832,201 (GRCm39)	missense	possibly damaging	0.91
RF005:Vmn2r120	UTSW	17	57,828,991 (GRCm39)	missense	possibly damaging	0.65
Z1177:Vmn2r120	UTSW	17	57,816,245 (GRCm39)	missense	probably benign	0.00
Z1188:Vmn2r120	UTSW	17	57,829,436 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-10-07