Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01360:Vmn2r112'

75688

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r112

Ensembl Gene

ENSMUSG00000094921

Gene Name

vomeronasal 2, receptor 112

Synonyms

EG628185

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.105) question?

Stock #

IGL01360

Quality Score

Status

Chromosome

Chromosomal Location

22820129-22838114 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 22837603 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 688 (M688T)

Ref Sequence

ENSEMBL: ENSMUSP00000094994 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000097381]

AlphaFold

L7N221

Predicted Effect

probably benign
Transcript: ENSMUST00000097381
AA Change: M688T

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000094994
Gene: ENSMUSG00000094921
AA Change: M688T

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	2.8e-32	PFAM
Pfam:NCD3G	512	565	5.8e-21	PFAM
Pfam:7tm_3	598	833	6.5e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	T	A	1: 71,325,648 (GRCm39)	I1517L	possibly damaging	Het
Akap12	A	T	10: 4,307,537 (GRCm39)	D1449V	probably benign	Het
Alg6	T	A	4: 99,630,643 (GRCm39)	Y161N	probably benign	Het
Arhgap45	A	T	10: 79,864,482 (GRCm39)		probably benign	Het
Arhgap5	A	T	12: 52,565,023 (GRCm39)	I665F	probably damaging	Het
Bbs4	A	G	9: 59,247,131 (GRCm39)	V123A	possibly damaging	Het
Carm1	C	T	9: 21,498,598 (GRCm39)	T480I	probably benign	Het
Catsperb	G	A	12: 101,591,513 (GRCm39)	V1032M	probably damaging	Het
Cdc42bpb	A	C	12: 111,308,509 (GRCm39)	I101S	probably damaging	Het
Copa	C	A	1: 171,915,155 (GRCm39)		probably null	Het
Cramp1	T	C	17: 25,216,547 (GRCm39)	I189V	probably damaging	Het
Dhx33	G	A	11: 70,884,687 (GRCm39)	Q40*	probably null	Het
Egf	A	T	3: 129,533,669 (GRCm39)	F57Y	probably damaging	Het
Flt4	T	C	11: 49,534,333 (GRCm39)	I1168T	probably benign	Het
Gm14178	A	G	11: 99,638,269 (GRCm39)	S37P	unknown	Het
Gpbp1	A	T	13: 111,563,075 (GRCm39)		probably benign	Het
Herc1	T	C	9: 66,390,981 (GRCm39)	S3980P	probably benign	Het
Itga6	T	C	2: 71,617,670 (GRCm39)		probably null	Het
Itgb4	T	C	11: 115,881,766 (GRCm39)	S772P	probably damaging	Het
Kcng4	C	A	8: 120,352,416 (GRCm39)	G498V	probably benign	Het
Lrp1	T	G	10: 127,381,689 (GRCm39)	D3795A	possibly damaging	Het
Lrrk2	T	A	15: 91,584,772 (GRCm39)		probably null	Het
Mettl25	A	T	10: 105,659,058 (GRCm39)	H408Q	probably damaging	Het
Mki67	T	C	7: 135,307,505 (GRCm39)	E457G	probably damaging	Het
Mpl	G	A	4: 118,312,858 (GRCm39)	T158I	possibly damaging	Het
Mtg2	C	T	2: 179,725,870 (GRCm39)	T160I	probably damaging	Het
Mtif2	A	G	11: 29,480,110 (GRCm39)	I59V	probably benign	Het
Ncapg	C	A	5: 45,831,727 (GRCm39)	S191*	probably null	Het
Nup214	T	C	2: 31,928,190 (GRCm39)		probably benign	Het
Or9m1	T	C	2: 87,733,871 (GRCm39)	T50A	probably benign	Het
Phf3	T	A	1: 30,847,809 (GRCm39)	T1245S	probably damaging	Het
Piezo2	T	C	18: 63,250,770 (GRCm39)	D443G	probably damaging	Het
Pramel19	A	T	4: 101,797,665 (GRCm39)	D21V	possibly damaging	Het
Ptchd4	C	A	17: 42,627,936 (GRCm39)	H132Q	probably benign	Het
Pum1	T	C	4: 130,455,481 (GRCm39)		probably benign	Het
Slc30a7	A	T	3: 115,783,765 (GRCm39)	V136E	probably damaging	Het
Slc5a10	A	G	11: 61,605,962 (GRCm39)	V116A	probably damaging	Het
Sos2	A	T	12: 69,637,574 (GRCm39)	S1046T	probably benign	Het
Svep1	A	G	4: 58,116,554 (GRCm39)	S899P	possibly damaging	Het
Tfr2	G	A	5: 137,569,953 (GRCm39)	V120I	probably benign	Het
Tnfrsf18	A	T	4: 156,112,493 (GRCm39)	R117*	probably null	Het
Trmt9b	A	G	8: 36,979,713 (GRCm39)	I439V	probably benign	Het
Vmn1r77	T	G	7: 11,775,315 (GRCm39)	F30L	probably benign	Het
Vmn2r93	T	A	17: 18,525,510 (GRCm39)	D389E	possibly damaging	Het
Zpld1	T	G	16: 55,046,748 (GRCm39)	N407T	probably benign	Het
Zranb3	C	T	1: 127,887,622 (GRCm39)	W935*	probably null	Het
Zyx	G	A	6: 42,327,378 (GRCm39)	R59Q	probably damaging	Het

Other mutations in Vmn2r112

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00341:Vmn2r112	APN	17	22,837,917 (GRCm39)	missense	probably benign	0.13
IGL01021:Vmn2r112	APN	17	22,837,885 (GRCm39)	missense	probably damaging	1.00
IGL01122:Vmn2r112	APN	17	22,821,988 (GRCm39)	missense	probably benign	0.00
IGL01536:Vmn2r112	APN	17	22,824,136 (GRCm39)	missense	probably damaging	1.00
IGL02148:Vmn2r112	APN	17	22,838,013 (GRCm39)	missense	probably damaging	1.00
IGL02465:Vmn2r112	APN	17	22,833,975 (GRCm39)	missense	probably damaging	1.00
PIT4576001:Vmn2r112	UTSW	17	22,833,912 (GRCm39)	missense	probably benign	0.00
R0278:Vmn2r112	UTSW	17	22,821,987 (GRCm39)	missense	probably benign	0.44
R0328:Vmn2r112	UTSW	17	22,824,251 (GRCm39)	missense	probably benign	0.01
R0583:Vmn2r112	UTSW	17	22,837,930 (GRCm39)	missense	probably damaging	1.00
R0831:Vmn2r112	UTSW	17	22,833,980 (GRCm39)	missense	probably damaging	0.99
R1080:Vmn2r112	UTSW	17	22,837,980 (GRCm39)	missense	probably damaging	1.00
R1245:Vmn2r112	UTSW	17	22,822,228 (GRCm39)	missense	probably benign	0.03
R1321:Vmn2r112	UTSW	17	22,837,500 (GRCm39)	nonsense	probably null
R1381:Vmn2r112	UTSW	17	22,837,467 (GRCm39)	missense	probably damaging	1.00
R1514:Vmn2r112	UTSW	17	22,821,825 (GRCm39)	missense	probably benign	0.40
R1519:Vmn2r112	UTSW	17	22,837,884 (GRCm39)	missense	possibly damaging	0.83
R1572:Vmn2r112	UTSW	17	22,822,125 (GRCm39)	missense	possibly damaging	0.61
R1590:Vmn2r112	UTSW	17	22,833,989 (GRCm39)	critical splice donor site	probably null
R1640:Vmn2r112	UTSW	17	22,824,097 (GRCm39)	missense	probably benign	0.01
R2221:Vmn2r112	UTSW	17	22,820,214 (GRCm39)	missense	possibly damaging	0.86
R2223:Vmn2r112	UTSW	17	22,820,214 (GRCm39)	missense	possibly damaging	0.86
R2310:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R2312:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R2337:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R2339:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R2340:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R2341:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R2342:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R2401:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R2860:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R2861:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R2926:Vmn2r112	UTSW	17	22,833,984 (GRCm39)	missense	possibly damaging	0.90
R3236:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R3237:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R3977:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R3979:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R4168:Vmn2r112	UTSW	17	22,822,069 (GRCm39)	missense	probably benign	0.01
R4256:Vmn2r112	UTSW	17	22,837,393 (GRCm39)	missense	probably damaging	1.00
R4386:Vmn2r112	UTSW	17	22,820,303 (GRCm39)	missense	probably benign	0.36
R4912:Vmn2r112	UTSW	17	22,822,363 (GRCm39)	missense	probably damaging	0.99
R4947:Vmn2r112	UTSW	17	22,821,860 (GRCm39)	missense	probably benign	0.02
R5446:Vmn2r112	UTSW	17	22,837,231 (GRCm39)	missense	probably damaging	1.00
R5870:Vmn2r112	UTSW	17	22,838,004 (GRCm39)	missense	probably benign	0.00
R6351:Vmn2r112	UTSW	17	22,820,259 (GRCm39)	missense	probably benign
R6384:Vmn2r112	UTSW	17	22,824,136 (GRCm39)	missense	probably damaging	1.00
R6390:Vmn2r112	UTSW	17	22,824,230 (GRCm39)	missense	probably benign	0.01
R6401:Vmn2r112	UTSW	17	22,822,532 (GRCm39)	nonsense	probably null
R6405:Vmn2r112	UTSW	17	22,837,216 (GRCm39)	missense	probably damaging	1.00
R6620:Vmn2r112	UTSW	17	22,822,082 (GRCm39)	missense	probably benign	0.00
R6648:Vmn2r112	UTSW	17	22,837,467 (GRCm39)	missense	probably damaging	1.00
R6649:Vmn2r112	UTSW	17	22,820,160 (GRCm39)	missense	probably null	1.00
R6653:Vmn2r112	UTSW	17	22,820,160 (GRCm39)	missense	probably null	1.00
R6654:Vmn2r112	UTSW	17	22,822,450 (GRCm39)	missense	possibly damaging	0.89
R6700:Vmn2r112	UTSW	17	22,822,462 (GRCm39)	missense	possibly damaging	0.53
R6993:Vmn2r112	UTSW	17	22,822,195 (GRCm39)	missense	probably benign	0.01
R7052:Vmn2r112	UTSW	17	22,821,507 (GRCm39)	missense	probably benign
R7454:Vmn2r112	UTSW	17	22,822,288 (GRCm39)	missense	probably benign	0.00
R7763:Vmn2r112	UTSW	17	22,822,099 (GRCm39)	missense	probably damaging	1.00
R8032:Vmn2r112	UTSW	17	22,822,375 (GRCm39)	missense	probably benign	0.21
R8177:Vmn2r112	UTSW	17	22,822,594 (GRCm39)	missense	possibly damaging	0.47
R8263:Vmn2r112	UTSW	17	22,824,140 (GRCm39)	missense	probably damaging	1.00
R8395:Vmn2r112	UTSW	17	22,837,587 (GRCm39)	missense	possibly damaging	0.94
R8492:Vmn2r112	UTSW	17	22,821,470 (GRCm39)	missense	probably benign	0.03
R8889:Vmn2r112	UTSW	17	22,837,612 (GRCm39)	missense	probably damaging	1.00
R8892:Vmn2r112	UTSW	17	22,837,612 (GRCm39)	missense	probably damaging	1.00
R9246:Vmn2r112	UTSW	17	22,824,088 (GRCm39)	missense	probably benign	0.21
R9269:Vmn2r112	UTSW	17	22,820,213 (GRCm39)	missense	probably benign
R9273:Vmn2r112	UTSW	17	22,837,721 (GRCm39)	missense	probably damaging	1.00
R9288:Vmn2r112	UTSW	17	22,822,323 (GRCm39)	missense	probably damaging	1.00
R9352:Vmn2r112	UTSW	17	22,822,479 (GRCm39)	missense	probably damaging	0.98
R9406:Vmn2r112	UTSW	17	22,824,223 (GRCm39)	nonsense	probably null
R9432:Vmn2r112	UTSW	17	22,821,233 (GRCm39)	missense
R9728:Vmn2r112	UTSW	17	22,824,108 (GRCm39)	missense	probably damaging	0.96
Z1088:Vmn2r112	UTSW	17	22,824,059 (GRCm39)	missense	possibly damaging	0.89

Posted On

2013-10-07