Incidental Mutation 'IGL01593:Atp6v0d2'
ID |
91660 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Atp6v0d2
|
Ensembl Gene |
ENSMUSG00000028238 |
Gene Name |
ATPase, H+ transporting, lysosomal V0 subunit D2 |
Synonyms |
1620401A02Rik |
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
IGL01593
|
Quality Score |
|
Status
|
|
Chromosome |
4 |
Chromosomal Location |
19876838-19922566 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to A
at 19881436 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Arginine to Leucine
at position 219
(R219L)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000029900
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000029900]
|
AlphaFold |
Q80SY3 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000029900
AA Change: R219L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000029900 Gene: ENSMUSG00000028238 AA Change: R219L
Domain | Start | End | E-Value | Type |
Pfam:vATP-synt_AC39
|
16 |
346 |
6.2e-113 |
PFAM |
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Mice homozygous for a null mutation display osteopetrosis and impaired osteoclast maturation. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 32 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abcc12 |
A |
T |
8: 87,284,279 (GRCm39) |
I310N |
probably damaging |
Het |
Abtb3 |
T |
A |
10: 85,490,339 (GRCm39) |
|
probably benign |
Het |
Ackr4 |
C |
T |
9: 103,963,130 (GRCm39) |
|
probably benign |
Het |
Ankib1 |
A |
T |
5: 3,782,590 (GRCm39) |
D346E |
probably benign |
Het |
Asap2 |
G |
T |
12: 21,263,203 (GRCm39) |
A273S |
probably null |
Het |
Atp6v1e2 |
A |
T |
17: 87,251,727 (GRCm39) |
F224I |
probably damaging |
Het |
Bnc2 |
T |
C |
4: 84,194,478 (GRCm39) |
|
probably null |
Het |
Cd33 |
A |
G |
7: 43,179,705 (GRCm39) |
L241P |
possibly damaging |
Het |
Clec4g |
A |
T |
8: 3,769,474 (GRCm39) |
|
probably null |
Het |
Dym |
C |
T |
18: 75,247,852 (GRCm39) |
|
probably benign |
Het |
Enpp5 |
A |
G |
17: 44,391,612 (GRCm39) |
T14A |
probably benign |
Het |
Ggt1 |
T |
C |
10: 75,421,121 (GRCm39) |
|
probably null |
Het |
Gm17541 |
T |
A |
12: 4,739,868 (GRCm39) |
|
probably benign |
Het |
Gpr39 |
A |
T |
1: 125,605,188 (GRCm39) |
I39F |
probably benign |
Het |
Kcnb1 |
G |
T |
2: 166,948,127 (GRCm39) |
F240L |
probably damaging |
Het |
Kcnt1 |
T |
A |
2: 25,788,766 (GRCm39) |
V400E |
probably damaging |
Het |
Klhdc7a |
A |
G |
4: 139,694,125 (GRCm39) |
I274T |
probably damaging |
Het |
Lrwd1 |
A |
T |
5: 136,163,483 (GRCm39) |
L71Q |
probably damaging |
Het |
Mycbp2 |
A |
T |
14: 103,528,723 (GRCm39) |
|
probably null |
Het |
Nckap1 |
A |
T |
2: 80,350,914 (GRCm39) |
M725K |
probably benign |
Het |
Odad2 |
T |
C |
18: 7,127,345 (GRCm39) |
K956R |
probably benign |
Het |
Or2b7 |
T |
A |
13: 21,739,389 (GRCm39) |
I268F |
probably damaging |
Het |
Pole2 |
C |
T |
12: 69,269,873 (GRCm39) |
|
probably null |
Het |
Prss32 |
A |
G |
17: 24,074,982 (GRCm39) |
T111A |
probably benign |
Het |
Rgs9 |
A |
G |
11: 109,139,875 (GRCm39) |
|
probably benign |
Het |
Slc2a4 |
A |
G |
11: 69,835,654 (GRCm39) |
C361R |
probably damaging |
Het |
Ston1 |
G |
A |
17: 88,944,438 (GRCm39) |
G615R |
probably null |
Het |
Tas2r139 |
T |
G |
6: 42,117,891 (GRCm39) |
W8G |
probably benign |
Het |
Tmem101 |
A |
T |
11: 102,046,704 (GRCm39) |
L55Q |
probably damaging |
Het |
Tnni3k |
T |
C |
3: 154,646,666 (GRCm39) |
|
probably null |
Het |
Uba2 |
A |
G |
7: 33,845,689 (GRCm39) |
V478A |
probably damaging |
Het |
Vps13a |
T |
C |
19: 16,739,545 (GRCm39) |
D52G |
probably damaging |
Het |
|
Other mutations in Atp6v0d2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01759:Atp6v0d2
|
APN |
4 |
19,878,335 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02006:Atp6v0d2
|
APN |
4 |
19,878,325 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02515:Atp6v0d2
|
APN |
4 |
19,880,063 (GRCm39) |
missense |
possibly damaging |
0.63 |
IGL03100:Atp6v0d2
|
APN |
4 |
19,910,586 (GRCm39) |
critical splice donor site |
probably null |
|
IGL02796:Atp6v0d2
|
UTSW |
4 |
19,887,324 (GRCm39) |
missense |
probably damaging |
1.00 |
R0083:Atp6v0d2
|
UTSW |
4 |
19,880,001 (GRCm39) |
splice site |
probably benign |
|
R0133:Atp6v0d2
|
UTSW |
4 |
19,910,578 (GRCm39) |
splice site |
probably benign |
|
R0371:Atp6v0d2
|
UTSW |
4 |
19,880,033 (GRCm39) |
missense |
possibly damaging |
0.92 |
R0845:Atp6v0d2
|
UTSW |
4 |
19,880,055 (GRCm39) |
missense |
probably benign |
0.02 |
R1279:Atp6v0d2
|
UTSW |
4 |
19,878,298 (GRCm39) |
missense |
probably benign |
0.02 |
R1541:Atp6v0d2
|
UTSW |
4 |
19,910,645 (GRCm39) |
missense |
probably damaging |
1.00 |
R1802:Atp6v0d2
|
UTSW |
4 |
19,922,366 (GRCm39) |
critical splice donor site |
probably null |
|
R3417:Atp6v0d2
|
UTSW |
4 |
19,888,829 (GRCm39) |
unclassified |
probably benign |
|
R3833:Atp6v0d2
|
UTSW |
4 |
19,922,395 (GRCm39) |
missense |
probably damaging |
1.00 |
R3884:Atp6v0d2
|
UTSW |
4 |
19,910,677 (GRCm39) |
missense |
probably damaging |
1.00 |
R5158:Atp6v0d2
|
UTSW |
4 |
19,878,292 (GRCm39) |
missense |
probably damaging |
1.00 |
R6284:Atp6v0d2
|
UTSW |
4 |
19,922,605 (GRCm39) |
splice site |
probably null |
|
R7290:Atp6v0d2
|
UTSW |
4 |
19,880,060 (GRCm39) |
missense |
probably benign |
0.44 |
R7341:Atp6v0d2
|
UTSW |
4 |
19,887,330 (GRCm39) |
missense |
possibly damaging |
0.46 |
R7832:Atp6v0d2
|
UTSW |
4 |
19,922,400 (GRCm39) |
missense |
probably benign |
0.18 |
R8231:Atp6v0d2
|
UTSW |
4 |
19,881,451 (GRCm39) |
missense |
probably damaging |
1.00 |
R8757:Atp6v0d2
|
UTSW |
4 |
19,910,649 (GRCm39) |
missense |
probably benign |
|
R8759:Atp6v0d2
|
UTSW |
4 |
19,910,649 (GRCm39) |
missense |
probably benign |
|
R8811:Atp6v0d2
|
UTSW |
4 |
19,922,397 (GRCm39) |
missense |
probably benign |
0.05 |
R9227:Atp6v0d2
|
UTSW |
4 |
19,878,374 (GRCm39) |
missense |
probably benign |
|
R9334:Atp6v0d2
|
UTSW |
4 |
19,890,695 (GRCm39) |
missense |
probably damaging |
1.00 |
R9378:Atp6v0d2
|
UTSW |
4 |
19,922,377 (GRCm39) |
missense |
probably benign |
0.02 |
R9716:Atp6v0d2
|
UTSW |
4 |
19,890,834 (GRCm39) |
missense |
probably benign |
|
|
Posted On |
2013-12-09 |