Incidental Mutation 'R1099:Or2z9'
ID 97909
Institutional Source Beutler Lab
Gene Symbol Or2z9
Ensembl Gene ENSMUSG00000061561
Gene Name olfactory receptor family 2 subfamily Z member 9
Synonyms MOR282-1, GA_x6K02T2NUPS-231686-232630, Olfr373, MOR282-2
MMRRC Submission 039173-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.250) question?
Stock # R1099 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 72853606-72854550 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 72854503 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 300 (S300T)
Ref Sequence ENSEMBL: ENSMUSP00000149452 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074540] [ENSMUST00000213940] [ENSMUST00000215198]
AlphaFold E9Q4J3
Predicted Effect probably benign
Transcript: ENSMUST00000074540
AA Change: S300T

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000074128
Gene: ENSMUSG00000061561
AA Change: S300T

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 6.1e-57 PFAM
Pfam:7TM_GPCR_Srsx 35 253 6.5e-8 PFAM
Pfam:7tm_1 41 290 4.9e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213940
AA Change: S300T

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
Predicted Effect probably benign
Transcript: ENSMUST00000215198
AA Change: S300T

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.3%
  • 20x: 93.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930433I11Rik A T 7: 40,642,480 (GRCm39) T141S probably benign Het
Abca7 G T 10: 79,849,577 (GRCm39) E1921* probably null Het
Acnat2 G A 4: 49,380,484 (GRCm39) T298I probably benign Het
Agbl4 T C 4: 110,812,860 (GRCm39) probably null Het
Angpt2 T A 8: 18,749,149 (GRCm39) T323S probably damaging Het
Ano2 A G 6: 125,784,810 (GRCm39) K299R probably damaging Het
Armc2 G T 10: 41,793,183 (GRCm39) Q814K probably benign Het
Atp9b A C 18: 80,901,841 (GRCm39) I263S probably damaging Het
Cadps2 A G 6: 23,599,478 (GRCm39) I276T probably damaging Het
Casp12 T A 9: 5,352,204 (GRCm39) H135Q probably benign Het
Ccdc180 A G 4: 45,914,225 (GRCm39) I621V probably benign Het
Cd160 G A 3: 96,713,156 (GRCm39) A36V probably damaging Het
Ctcfl A T 2: 172,954,153 (GRCm39) C315S probably damaging Het
Egflam A G 15: 7,281,903 (GRCm39) V411A probably benign Het
Ezh1 T C 11: 101,084,634 (GRCm39) probably null Het
Fam171a1 T A 2: 3,226,354 (GRCm39) S371T probably benign Het
Hspbap1 T G 16: 35,645,314 (GRCm39) F333C probably damaging Het
Ky G C 9: 102,414,923 (GRCm39) W278C probably damaging Het
Lrig3 T A 10: 125,842,883 (GRCm39) probably null Het
Map3k6 A T 4: 132,974,439 (GRCm39) S580C probably damaging Het
Mark2 T C 19: 7,254,790 (GRCm39) T219A probably benign Het
Mbd5 A G 2: 49,148,156 (GRCm39) I789V probably benign Het
Myo18a T A 11: 77,709,727 (GRCm39) probably null Het
Nos1 A G 5: 118,061,460 (GRCm39) T929A probably damaging Het
Or2a20 T C 6: 43,194,558 (GRCm39) F237S probably damaging Het
Oxtr C T 6: 112,454,138 (GRCm39) R42Q probably benign Het
Palmd T C 3: 116,716,874 (GRCm39) N541S possibly damaging Het
Pdzd2 A G 15: 12,373,173 (GRCm39) S2321P probably damaging Het
Prdm8 T G 5: 98,331,361 (GRCm39) I71S probably damaging Het
Prkg1 A C 19: 30,549,012 (GRCm39) S654R probably benign Het
Psmf1 A T 2: 151,560,590 (GRCm39) H260Q probably damaging Het
Rp1 A T 1: 4,422,513 (GRCm39) I179N possibly damaging Het
Rreb1 A G 13: 38,132,867 (GRCm39) K1681E probably benign Het
Rtn1 A T 12: 72,351,241 (GRCm39) probably null Het
Scaf4 T A 16: 90,059,986 (GRCm39) I37F unknown Het
Sema4c A G 1: 36,591,191 (GRCm39) S383P probably damaging Het
Shc4 G T 2: 125,564,764 (GRCm39) D178E probably benign Het
Slc2a5 A G 4: 150,226,636 (GRCm39) N366S probably benign Het
Slc6a3 A G 13: 73,715,760 (GRCm39) N465S probably benign Het
Tbc1d9b C A 11: 50,037,135 (GRCm39) D261E probably benign Het
Tdrd3 A T 14: 87,724,675 (GRCm39) T359S probably damaging Het
Thap3 T C 4: 152,067,788 (GRCm39) M97V probably benign Het
Thg1l T A 11: 45,844,988 (GRCm39) Q88L possibly damaging Het
Tjp3 T C 10: 81,109,657 (GRCm39) T849A probably benign Het
Tomm70a G T 16: 56,963,180 (GRCm39) D400Y probably damaging Het
Trak2 T C 1: 58,961,000 (GRCm39) I177V probably benign Het
Trim66 T C 7: 109,074,661 (GRCm39) I533M probably benign Het
Ush2a T A 1: 188,380,545 (GRCm39) Y2285N probably benign Het
Ush2a C T 1: 188,596,836 (GRCm39) P3859S probably damaging Het
Other mutations in Or2z9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01592:Or2z9 APN 8 72,854,356 (GRCm39) missense probably damaging 1.00
IGL02440:Or2z9 APN 8 72,854,374 (GRCm39) missense probably damaging 1.00
IGL03403:Or2z9 APN 8 72,854,341 (GRCm39) missense probably benign 0.00
R1418:Or2z9 UTSW 8 72,854,231 (GRCm39) missense probably damaging 1.00
R1452:Or2z9 UTSW 8 72,854,020 (GRCm39) nonsense probably null
R1621:Or2z9 UTSW 8 72,853,973 (GRCm39) missense probably damaging 1.00
R2021:Or2z9 UTSW 8 72,853,930 (GRCm39) missense possibly damaging 0.90
R4230:Or2z9 UTSW 8 72,854,188 (GRCm39) missense probably damaging 1.00
R4290:Or2z9 UTSW 8 72,853,612 (GRCm39) missense probably benign
R5035:Or2z9 UTSW 8 72,853,922 (GRCm39) missense probably damaging 1.00
R6884:Or2z9 UTSW 8 72,854,345 (GRCm39) missense probably benign 0.26
R6909:Or2z9 UTSW 8 72,854,372 (GRCm39) missense possibly damaging 0.95
R7233:Or2z9 UTSW 8 72,853,900 (GRCm39) missense probably benign
R7304:Or2z9 UTSW 8 72,854,190 (GRCm39) nonsense probably null
R7312:Or2z9 UTSW 8 72,853,793 (GRCm39) missense probably damaging 1.00
R7701:Or2z9 UTSW 8 72,854,030 (GRCm39) missense probably damaging 1.00
R8789:Or2z9 UTSW 8 72,854,135 (GRCm39) missense probably damaging 1.00
Z1088:Or2z9 UTSW 8 72,854,361 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ATGAGTTGGCGCTCTCCATCTCTG -3'
(R):5'- CTGAAAGCCTGAGGTAACCTTCCTG -3'

Sequencing Primer
(F):5'- GAGCTGTCCTGCTCATGC -3'
(R):5'- caggcatccaccccaag -3'
Posted On 2014-01-05