Incidental Mutation 'R0918:Or5ak4'
ID 99130
Institutional Source Beutler Lab
Gene Symbol Or5ak4
Ensembl Gene ENSMUSG00000075223
Gene Name olfactory receptor family 5 subfamily AK member 4
Synonyms Olfr987, MOR203-7P, GA_x6K02T2Q125-46808500-46807571
MMRRC Submission 039068-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R0918 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 85161311-85162240 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) A to G at 85162276 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000150619 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099929] [ENSMUST00000111598] [ENSMUST00000216347]
AlphaFold Q7TRA2
Predicted Effect probably benign
Transcript: ENSMUST00000099929
SMART Domains Protein: ENSMUSP00000097513
Gene: ENSMUSG00000075223

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.4e-50 PFAM
Pfam:7TM_GPCR_Srsx 35 254 5.9e-6 PFAM
Pfam:7tm_1 41 290 1.9e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111598
SMART Domains Protein: ENSMUSP00000107225
Gene: ENSMUSG00000075223

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 35 254 5.9e-6 PFAM
Pfam:7tm_1 41 290 1.7e-31 PFAM
Pfam:7tm_4 139 283 6.6e-46 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216347
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.7%
  • 10x: 96.2%
  • 20x: 90.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadac T G 3: 59,946,953 (GRCm39) I217R probably damaging Het
Acp1 G T 12: 30,955,126 (GRCm39) S20* probably null Het
Adcy3 A G 12: 4,248,360 (GRCm39) D474G probably benign Het
Apob T C 12: 8,033,941 (GRCm39) I217T probably benign Het
Cdh12 G A 15: 21,492,685 (GRCm39) V235I probably damaging Het
Cdhr5 T A 7: 140,852,062 (GRCm39) T197S probably damaging Het
Cerkl A G 2: 79,163,973 (GRCm39) I449T probably benign Het
Cpz A G 5: 35,674,998 (GRCm39) Y84H probably damaging Het
Drosha T C 15: 12,842,619 (GRCm39) probably null Het
Fbxo11 A T 17: 88,305,031 (GRCm39) N613K probably damaging Het
Fes G T 7: 80,030,953 (GRCm39) T536K probably damaging Het
Gm13941 G C 2: 110,930,945 (GRCm39) T76R unknown Het
Lrp1 T C 10: 127,429,834 (GRCm39) E412G probably damaging Het
Map3k12 T C 15: 102,412,287 (GRCm39) I285V probably damaging Het
Map3k13 G A 16: 21,744,990 (GRCm39) D850N probably damaging Het
Mapk4 C T 18: 74,103,408 (GRCm39) V34M probably damaging Het
Morn1 T A 4: 155,171,928 (GRCm39) W43R probably damaging Het
Ncan T G 8: 70,561,039 (GRCm39) M643L possibly damaging Het
Npc1l1 G A 11: 6,168,239 (GRCm39) T984M probably damaging Het
Or14c44 A G 7: 86,062,403 (GRCm39) T278A probably benign Het
Or5a3 A G 19: 12,400,599 (GRCm39) K309E probably benign Het
Or5p5 T C 7: 107,414,418 (GRCm39) I209T probably benign Het
Pcdhb22 T C 18: 37,653,067 (GRCm39) F255L probably damaging Het
Pi4ka T C 16: 17,103,124 (GRCm39) D1697G possibly damaging Het
Pla2g12b A G 10: 59,257,306 (GRCm39) D163G probably damaging Het
Pot1a G A 6: 25,756,267 (GRCm39) T359M possibly damaging Het
Sass6 G A 3: 116,397,172 (GRCm39) probably null Het
Scn1a C T 2: 66,153,651 (GRCm39) probably null Het
Slc38a1 A G 15: 96,507,743 (GRCm39) L103P probably damaging Het
Slc38a6 T A 12: 73,391,559 (GRCm39) probably null Het
Smarca4 C T 9: 21,547,511 (GRCm39) P265S probably benign Het
Snrpa1 A G 7: 65,720,363 (GRCm39) T189A probably benign Het
Snx11 G A 11: 96,660,104 (GRCm39) P195L possibly damaging Het
Spen T G 4: 141,212,875 (GRCm39) I584L unknown Het
Sult2a5 T A 7: 13,359,334 (GRCm39) H103Q probably benign Het
Syce1 T C 7: 140,360,436 (GRCm39) K50E probably damaging Het
Timm21 G C 18: 84,967,387 (GRCm39) L130V probably damaging Het
Tmem132a A G 19: 10,835,477 (GRCm39) S1018P probably damaging Het
Other mutations in Or5ak4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01766:Or5ak4 APN 2 85,161,945 (GRCm39) missense probably benign 0.37
IGL02267:Or5ak4 APN 2 85,161,465 (GRCm39) missense probably damaging 1.00
IGL03167:Or5ak4 APN 2 85,161,664 (GRCm39) missense probably benign 0.01
IGL03195:Or5ak4 APN 2 85,161,864 (GRCm39) missense probably damaging 1.00
R1573:Or5ak4 UTSW 2 85,161,687 (GRCm39) missense probably damaging 1.00
R1956:Or5ak4 UTSW 2 85,161,444 (GRCm39) missense probably benign 0.00
R2165:Or5ak4 UTSW 2 85,161,446 (GRCm39) missense probably benign
R4086:Or5ak4 UTSW 2 85,162,170 (GRCm39) missense probably benign 0.35
R5386:Or5ak4 UTSW 2 85,161,979 (GRCm39) missense probably benign 0.00
R5652:Or5ak4 UTSW 2 85,161,717 (GRCm39) missense probably damaging 1.00
R6753:Or5ak4 UTSW 2 85,162,142 (GRCm39) missense probably benign
R6755:Or5ak4 UTSW 2 85,162,142 (GRCm39) missense probably benign
R8347:Or5ak4 UTSW 2 85,162,047 (GRCm39) missense probably damaging 0.99
R9158:Or5ak4 UTSW 2 85,161,348 (GRCm39) missense probably benign 0.00
R9470:Or5ak4 UTSW 2 85,161,673 (GRCm39) missense probably damaging 1.00
Z1176:Or5ak4 UTSW 2 85,162,237 (GRCm39) missense probably benign 0.00
Predicted Primers
Posted On 2014-01-10