Incidental Mutation 'IGL01992:Nucks1'
ID 183583
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Nucks1
Ensembl Gene ENSMUSG00000026434
Gene Name nuclear casein kinase and cyclin-dependent kinase substrate 1
Synonyms Nucks, 8430423A01Rik, 2700010L10Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.462) question?
Stock # IGL01992
Quality Score
Status
Chromosome 1
Chromosomal Location 131838272-131864059 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 131858828 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 196 (K196E)
Ref Sequence ENSEMBL: ENSMUSP00000140818 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062264] [ENSMUST00000189946]
AlphaFold Q80XU3
Predicted Effect unknown
Transcript: ENSMUST00000062264
AA Change: K197E
SMART Domains Protein: ENSMUSP00000062576
Gene: ENSMUSG00000026434
AA Change: K197E

DomainStartEndE-ValueType
low complexity region 54 87 N/A INTRINSIC
low complexity region 90 104 N/A INTRINSIC
low complexity region 109 122 N/A INTRINSIC
low complexity region 132 175 N/A INTRINSIC
low complexity region 192 234 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000187405
Predicted Effect unknown
Transcript: ENSMUST00000189946
AA Change: K196E
SMART Domains Protein: ENSMUSP00000140818
Gene: ENSMUSG00000026434
AA Change: K196E

DomainStartEndE-ValueType
low complexity region 54 87 N/A INTRINSIC
low complexity region 90 104 N/A INTRINSIC
low complexity region 109 122 N/A INTRINSIC
low complexity region 131 174 N/A INTRINSIC
low complexity region 191 233 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195496
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano3 A G 2: 110,488,564 (GRCm39) M956T probably damaging Het
Ap2b1 T G 11: 83,226,356 (GRCm39) V289G probably damaging Het
Cacnb4 G T 2: 52,355,682 (GRCm39) H208Q probably damaging Het
Calhm6 A T 10: 34,003,533 (GRCm39) C125S probably damaging Het
Cd5l G A 3: 87,275,118 (GRCm39) R219Q probably benign Het
Dzip1l G T 9: 99,545,739 (GRCm39) G663W probably damaging Het
Ecel1 G A 1: 87,077,577 (GRCm39) probably benign Het
Eno1 A G 4: 150,323,993 (GRCm39) T19A probably damaging Het
Fndc3a G A 14: 72,811,996 (GRCm39) T315I probably benign Het
Galr1 T C 18: 82,411,942 (GRCm39) N308S probably damaging Het
Get3 G A 8: 85,745,185 (GRCm39) A294V possibly damaging Het
Maf A T 8: 116,432,702 (GRCm39) S301T probably damaging Het
Map3k5 C T 10: 19,904,879 (GRCm39) R394* probably null Het
Mroh8 C T 2: 157,055,616 (GRCm39) G994D probably damaging Het
Myo10 T C 15: 25,799,634 (GRCm39) V653A possibly damaging Het
Nup42 T C 5: 24,386,101 (GRCm39) V211A probably benign Het
Or4n4 C A 14: 50,518,798 (GRCm39) R304L probably benign Het
Or7e178 A T 9: 20,226,015 (GRCm39) I59N probably damaging Het
Or7g32 A T 9: 19,408,070 (GRCm39) I9F probably benign Het
Piwil1 C T 5: 128,824,396 (GRCm39) T493I probably null Het
Plcd1 T C 9: 118,905,053 (GRCm39) H216R probably benign Het
Pmp2 A T 3: 10,247,541 (GRCm39) Y49* probably null Het
Rnf38 A G 4: 44,138,806 (GRCm39) V229A probably damaging Het
Saxo2 T C 7: 82,284,108 (GRCm39) D250G probably damaging Het
Scn8a T G 15: 100,866,938 (GRCm39) V98G probably damaging Het
Scnn1a T A 6: 125,315,900 (GRCm39) probably null Het
Sepsecs C T 5: 52,801,402 (GRCm39) R420Q probably benign Het
Slit2 T C 5: 48,395,759 (GRCm39) S725P probably benign Het
Stk16 A G 1: 75,189,835 (GRCm39) Q207R probably benign Het
Tapt1 C T 5: 44,336,332 (GRCm39) V446M probably damaging Het
Tent5c A T 3: 100,379,946 (GRCm39) M270K probably damaging Het
Tex56 C T 13: 35,108,516 (GRCm39) probably null Het
Tnni3k A C 3: 154,667,663 (GRCm39) V250G probably damaging Het
Ttll8 C T 15: 88,799,848 (GRCm39) G531E possibly damaging Het
U2surp T A 9: 95,346,472 (GRCm39) E862D possibly damaging Het
U2surp A G 9: 95,364,234 (GRCm39) F561L probably damaging Het
Unc5d A G 8: 29,142,819 (GRCm39) Y878H probably damaging Het
Ust A G 10: 8,173,842 (GRCm39) M221T probably benign Het
Wasf3 T C 5: 146,392,401 (GRCm39) F157S probably damaging Het
Wdr64 G A 1: 175,533,637 (GRCm39) C91Y probably damaging Het
Zan T C 5: 137,422,368 (GRCm39) Y2750C unknown Het
Other mutations in Nucks1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02606:Nucks1 APN 1 131,852,363 (GRCm39) missense probably damaging 0.98
R0190:Nucks1 UTSW 1 131,852,329 (GRCm39) missense probably damaging 0.99
R5028:Nucks1 UTSW 1 131,855,840 (GRCm39) missense possibly damaging 0.95
R5377:Nucks1 UTSW 1 131,846,771 (GRCm39) missense probably damaging 0.96
R7674:Nucks1 UTSW 1 131,858,844 (GRCm39) missense probably benign 0.34
R7921:Nucks1 UTSW 1 131,838,474 (GRCm39) start codon destroyed probably null 0.01
R8483:Nucks1 UTSW 1 131,855,829 (GRCm39) missense possibly damaging 0.92
R8493:Nucks1 UTSW 1 131,857,473 (GRCm39) missense probably benign 0.14
R9482:Nucks1 UTSW 1 131,846,744 (GRCm39) missense probably benign 0.33
Z1177:Nucks1 UTSW 1 131,855,914 (GRCm39) missense probably benign 0.17
Posted On 2014-05-07