Incidental Mutation 'IGL02032:Fbxo36'
ID184408
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fbxo36
Ensembl Gene ENSMUSG00000073633
Gene NameF-box protein 36
Synonyms0610008D19Rik, 1110020F21Rik, 2410002G19Rik, D1Ertd757e
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02032
Quality Score
Status
Chromosome1
Chromosomal Location84839841-84900487 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to G at 84896666 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000095276 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097672]
Predicted Effect probably benign
Transcript: ENSMUST00000097672
SMART Domains Protein: ENSMUSP00000095276
Gene: ENSMUSG00000073633

DomainStartEndE-ValueType
FBOX 97 137 1.58e-2 SMART
low complexity region 168 180 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139562
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143656
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151737
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the F-box protein family, such as FBXO36, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arap2 T A 5: 62,670,997 I944F probably damaging Het
Arhgef1 A G 7: 24,923,371 K614R probably benign Het
Cep170b T C 12: 112,737,333 probably null Het
Cps1 A T 1: 67,230,315 Y1491F probably benign Het
Dennd2d T C 3: 106,491,227 I176T probably damaging Het
Dnah1 T C 14: 31,274,369 Y2670C probably benign Het
Dock8 A T 19: 25,130,405 H833L probably damaging Het
Ell G A 8: 70,586,001 A463T probably benign Het
Emsy G T 7: 98,590,780 D1089E possibly damaging Het
Erc1 T G 6: 119,630,609 K677N probably damaging Het
Exd1 T G 2: 119,533,467 Q140P probably damaging Het
Fam114a1 T A 5: 65,015,371 V284E probably benign Het
Fig4 A T 10: 41,303,006 V16E probably benign Het
Gm4778 T C 3: 94,266,333 V212A probably damaging Het
Gm4788 G A 1: 139,774,546 P67S probably damaging Het
H2-M1 A T 17: 36,671,876 Y31N probably damaging Het
Lrp5 A G 19: 3,615,886 probably benign Het
Nol8 A G 13: 49,672,772 T1023A probably benign Het
Olfr362 A T 2: 37,104,761 S296R probably damaging Het
Pygm A T 19: 6,388,087 T141S probably benign Het
Soat1 A G 1: 156,440,575 I254T probably benign Het
Stat5a A T 11: 100,861,828 D79V probably damaging Het
Ttn G T 2: 76,944,088 T2158N probably damaging Het
Usp29 A G 7: 6,962,018 K287E probably benign Het
Vav1 A T 17: 57,297,090 E164V possibly damaging Het
Vmn2r3 T A 3: 64,275,055 T408S possibly damaging Het
Vmn2r61 A T 7: 42,300,042 I629F probably damaging Het
Other mutations in Fbxo36
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02184:Fbxo36 APN 1 84881164 missense probably benign 0.00
R1551:Fbxo36 UTSW 1 84881114 missense probably damaging 1.00
R1621:Fbxo36 UTSW 1 84839874 start codon destroyed probably null 0.99
R2005:Fbxo36 UTSW 1 84900069 missense probably benign 0.16
R2403:Fbxo36 UTSW 1 84900102 missense probably damaging 0.99
R2857:Fbxo36 UTSW 1 84896595 missense probably benign 0.00
R2858:Fbxo36 UTSW 1 84896595 missense probably benign 0.00
R4618:Fbxo36 UTSW 1 84900028 missense probably damaging 1.00
R6207:Fbxo36 UTSW 1 84896530 nonsense probably null
R7472:Fbxo36 UTSW 1 84896580 missense probably damaging 1.00
Posted On2014-05-07