Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02032:Vmn2r3'

184383

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r3

Ensembl Gene

ENSMUSG00000091572

Gene Name

vomeronasal 2, receptor 3

Synonyms

EG637004

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02032

Quality Score

Status

Chromosome

Chromosomal Location

64166225-64197130 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 64182476 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 408 (T408S)

Ref Sequence

ENSEMBL: ENSMUSP00000134891 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170244] [ENSMUST00000176328]

AlphaFold

H3BJ88

Predicted Effect

possibly damaging
Transcript: ENSMUST00000170244
AA Change: T380S

PolyPhen 2 Score 0.949 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000126165
Gene: ENSMUSG00000091572
AA Change: T380S

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	64	479	4e-64	PFAM
Pfam:NCD3G	521	574	1.1e-17	PFAM
Pfam:7tm_3	605	842	2.9e-75	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000176328
AA Change: T408S

PolyPhen 2 Score 0.949 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000134891
Gene: ENSMUSG00000091572
AA Change: T408S

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	92	507	9.5e-66	PFAM
Pfam:NCD3G	549	602	8.8e-17	PFAM
Pfam:7tm_3	635	869	8.5e-48	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arap2	T	A	5: 62,828,340 (GRCm39)	I944F	probably damaging	Het
Arhgef1	A	G	7: 24,622,796 (GRCm39)	K614R	probably benign	Het
Cep170b	T	C	12: 112,703,767 (GRCm39)		probably null	Het
Cfhr4	G	A	1: 139,702,284 (GRCm39)	P67S	probably damaging	Het
Cps1	A	T	1: 67,269,474 (GRCm39)	Y1491F	probably benign	Het
Dennd2d	T	C	3: 106,398,543 (GRCm39)	I176T	probably damaging	Het
Dnah1	T	C	14: 30,996,326 (GRCm39)	Y2670C	probably benign	Het
Dock8	A	T	19: 25,107,769 (GRCm39)	H833L	probably damaging	Het
Ell	G	A	8: 71,038,651 (GRCm39)	A463T	probably benign	Het
Emsy	G	T	7: 98,239,987 (GRCm39)	D1089E	possibly damaging	Het
Erc1	T	G	6: 119,607,570 (GRCm39)	K677N	probably damaging	Het
Exd1	T	G	2: 119,363,948 (GRCm39)	Q140P	probably damaging	Het
Fam114a1	T	A	5: 65,172,714 (GRCm39)	V284E	probably benign	Het
Fbxo36	A	G	1: 84,874,387 (GRCm39)		probably benign	Het
Fig4	A	T	10: 41,179,002 (GRCm39)	V16E	probably benign	Het
H2-M1	A	T	17: 36,982,768 (GRCm39)	Y31N	probably damaging	Het
Lrp5	A	G	19: 3,665,886 (GRCm39)		probably benign	Het
Nol8	A	G	13: 49,826,248 (GRCm39)	T1023A	probably benign	Het
Or1b1	A	T	2: 36,994,773 (GRCm39)	S296R	probably damaging	Het
Pygm	A	T	19: 6,438,117 (GRCm39)	T141S	probably benign	Het
Soat1	A	G	1: 156,268,145 (GRCm39)	I254T	probably benign	Het
Spopfm1	T	C	3: 94,173,640 (GRCm39)	V212A	probably damaging	Het
Stat5a	A	T	11: 100,752,654 (GRCm39)	D79V	probably damaging	Het
Ttn	G	T	2: 76,774,432 (GRCm39)	T2158N	probably damaging	Het
Usp29	A	G	7: 6,965,017 (GRCm39)	K287E	probably benign	Het
Vav1	A	T	17: 57,604,090 (GRCm39)	E164V	possibly damaging	Het
Vmn2r61	A	T	7: 41,949,466 (GRCm39)	I629F	probably damaging	Het

Other mutations in Vmn2r3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01019:Vmn2r3	APN	3	64,167,304 (GRCm39)	missense	probably damaging	1.00
IGL01468:Vmn2r3	APN	3	64,182,382 (GRCm39)	missense	possibly damaging	0.57
IGL02405:Vmn2r3	APN	3	64,178,620 (GRCm39)	splice site	probably benign
IGL02640:Vmn2r3	APN	3	64,194,816 (GRCm39)	missense	probably benign
IGL02719:Vmn2r3	APN	3	64,183,031 (GRCm39)	missense	probably damaging	1.00
IGL02746:Vmn2r3	APN	3	64,167,239 (GRCm39)	missense	possibly damaging	0.74
IGL02952:Vmn2r3	APN	3	64,186,256 (GRCm39)	missense	probably damaging	1.00
IGL03390:Vmn2r3	APN	3	64,182,767 (GRCm39)	missense	possibly damaging	0.55
G1citation:Vmn2r3	UTSW	3	64,194,876 (GRCm39)	missense	probably benign	0.30
R0023:Vmn2r3	UTSW	3	64,182,787 (GRCm39)	missense	probably damaging	0.99
R0433:Vmn2r3	UTSW	3	64,183,054 (GRCm39)	missense	possibly damaging	0.51
R0647:Vmn2r3	UTSW	3	64,183,046 (GRCm39)	missense	probably damaging	1.00
R1071:Vmn2r3	UTSW	3	64,182,697 (GRCm39)	missense	possibly damaging	0.79
R1536:Vmn2r3	UTSW	3	64,182,538 (GRCm39)	missense	probably damaging	1.00
R1806:Vmn2r3	UTSW	3	64,194,810 (GRCm39)	missense	possibly damaging	0.73
R1806:Vmn2r3	UTSW	3	64,182,893 (GRCm39)	missense	probably benign	0.03
R1852:Vmn2r3	UTSW	3	64,166,815 (GRCm39)	missense	probably damaging	1.00
R1868:Vmn2r3	UTSW	3	64,166,537 (GRCm39)	missense	probably damaging	1.00
R2072:Vmn2r3	UTSW	3	64,182,493 (GRCm39)	missense	possibly damaging	0.87
R2240:Vmn2r3	UTSW	3	64,166,483 (GRCm39)	missense	probably benign	0.44
R2446:Vmn2r3	UTSW	3	64,182,733 (GRCm39)	missense	probably damaging	0.98
R4133:Vmn2r3	UTSW	3	64,183,138 (GRCm39)	missense	probably damaging	0.99
R4159:Vmn2r3	UTSW	3	64,194,850 (GRCm39)	nonsense	probably null
R4494:Vmn2r3	UTSW	3	64,182,692 (GRCm39)	missense	probably damaging	1.00
R4860:Vmn2r3	UTSW	3	64,183,022 (GRCm39)	missense	probably benign	0.00
R4895:Vmn2r3	UTSW	3	64,167,182 (GRCm39)	missense	probably benign	0.00
R4912:Vmn2r3	UTSW	3	64,166,618 (GRCm39)	missense	probably damaging	1.00
R5018:Vmn2r3	UTSW	3	64,178,774 (GRCm39)	missense	probably benign
R5033:Vmn2r3	UTSW	3	64,167,220 (GRCm39)	missense	probably benign	0.09
R5126:Vmn2r3	UTSW	3	64,166,740 (GRCm39)	missense	probably damaging	1.00
R5148:Vmn2r3	UTSW	3	64,186,247 (GRCm39)	missense	probably damaging	1.00
R5414:Vmn2r3	UTSW	3	64,166,978 (GRCm39)	nonsense	probably null
R5785:Vmn2r3	UTSW	3	64,166,444 (GRCm39)	missense	possibly damaging	0.89
R5905:Vmn2r3	UTSW	3	64,182,698 (GRCm39)	missense	probably benign	0.19
R5992:Vmn2r3	UTSW	3	64,167,068 (GRCm39)	missense	probably damaging	1.00
R6028:Vmn2r3	UTSW	3	64,182,698 (GRCm39)	missense	probably benign	0.19
R6331:Vmn2r3	UTSW	3	64,186,182 (GRCm39)	missense	probably damaging	1.00
R6378:Vmn2r3	UTSW	3	64,182,517 (GRCm39)	missense	probably damaging	1.00
R6775:Vmn2r3	UTSW	3	64,183,039 (GRCm39)	missense	possibly damaging	0.88
R6822:Vmn2r3	UTSW	3	64,194,876 (GRCm39)	missense	probably benign	0.30
R6826:Vmn2r3	UTSW	3	64,182,327 (GRCm39)	nonsense	probably null
R6886:Vmn2r3	UTSW	3	64,166,927 (GRCm39)	missense	probably damaging	1.00
R6971:Vmn2r3	UTSW	3	64,166,668 (GRCm39)	missense	probably damaging	0.99
R7154:Vmn2r3	UTSW	3	64,194,732 (GRCm39)	missense	probably benign	0.02
R7192:Vmn2r3	UTSW	3	64,167,364 (GRCm39)	missense	probably benign	0.24
R7282:Vmn2r3	UTSW	3	64,168,825 (GRCm39)	missense	possibly damaging	0.90
R7472:Vmn2r3	UTSW	3	64,182,953 (GRCm39)	missense	probably benign	0.00
R7563:Vmn2r3	UTSW	3	64,182,770 (GRCm39)	missense	possibly damaging	0.60
R7726:Vmn2r3	UTSW	3	64,182,939 (GRCm39)	nonsense	probably null
R7966:Vmn2r3	UTSW	3	64,186,235 (GRCm39)	missense	probably damaging	0.99
R8025:Vmn2r3	UTSW	3	64,182,871 (GRCm39)	missense	possibly damaging	0.91
R8050:Vmn2r3	UTSW	3	64,178,714 (GRCm39)	missense	probably damaging	0.99
R8300:Vmn2r3	UTSW	3	64,182,347 (GRCm39)	missense	probably benign	0.00
R8402:Vmn2r3	UTSW	3	64,178,617 (GRCm39)	splice site	probably benign
R8486:Vmn2r3	UTSW	3	64,186,370 (GRCm39)	missense	probably damaging	1.00
R8523:Vmn2r3	UTSW	3	64,182,311 (GRCm39)	missense	probably benign	0.03
R8678:Vmn2r3	UTSW	3	64,166,896 (GRCm39)	missense	possibly damaging	0.76
R8885:Vmn2r3	UTSW	3	64,182,383 (GRCm39)	missense	probably benign	0.00
R8886:Vmn2r3	UTSW	3	64,194,892 (GRCm39)	missense	possibly damaging	0.47
R8905:Vmn2r3	UTSW	3	64,166,695 (GRCm39)	missense	probably damaging	0.99
R8937:Vmn2r3	UTSW	3	64,166,673 (GRCm39)	missense	probably damaging	1.00
R8955:Vmn2r3	UTSW	3	64,168,803 (GRCm39)	missense	possibly damaging	0.56
R9172:Vmn2r3	UTSW	3	64,186,403 (GRCm39)	missense	possibly damaging	0.79
R9485:Vmn2r3	UTSW	3	64,183,046 (GRCm39)	missense	probably damaging	1.00
R9575:Vmn2r3	UTSW	3	64,178,735 (GRCm39)	missense	probably benign	0.01
R9618:Vmn2r3	UTSW	3	64,178,724 (GRCm39)	missense	probably damaging	0.98
X0022:Vmn2r3	UTSW	3	64,182,389 (GRCm39)	missense	probably damaging	1.00
X0022:Vmn2r3	UTSW	3	64,178,669 (GRCm39)	missense	possibly damaging	0.62

Posted On

2014-05-07