Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00979:Sdc3'

27347

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Sdc3

Ensembl Gene

ENSMUSG00000025743

Gene Name

syndecan 3

Synonyms

syn-3, Synd3

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.135) question?

Stock #

IGL00979

Quality Score

Status

Chromosome

Chromosomal Location

130519848-130553629 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 130545991 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 23 (I23V)

Ref Sequence

ENSEMBL: ENSMUSP00000118685 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000070478] [ENSMUST00000141297] [ENSMUST00000152591]

AlphaFold

Q64519

Predicted Effect

unknown
Transcript: ENSMUST00000070478
AA Change: I117V

SMART Domains

Protein: ENSMUSP00000065877
Gene: ENSMUSG00000025743
AA Change: I117V

Domain	Start	End	E-Value	Type
signal peptide	1	44	N/A	INTRINSIC
low complexity region	60	76	N/A	INTRINSIC
low complexity region	101	115	N/A	INTRINSIC
low complexity region	123	154	N/A	INTRINSIC
low complexity region	157	202	N/A	INTRINSIC
low complexity region	213	240	N/A	INTRINSIC
low complexity region	276	287	N/A	INTRINSIC
low complexity region	330	341	N/A	INTRINSIC
4.1m	408	426	2.51e-5	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000140623

Predicted Effect

unknown
Transcript: ENSMUST00000141297
AA Change: I23V

SMART Domains

Protein: ENSMUSP00000123608
Gene: ENSMUSG00000025743
AA Change: I23V

Domain	Start	End	E-Value	Type
low complexity region	7	21	N/A	INTRINSIC
low complexity region	29	60	N/A	INTRINSIC
low complexity region	63	108	N/A	INTRINSIC
low complexity region	119	146	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000146093

Predicted Effect

unknown
Transcript: ENSMUST00000152591
AA Change: I23V

SMART Domains

Protein: ENSMUSP00000118685
Gene: ENSMUSG00000025743
AA Change: I23V

Domain	Start	End	E-Value	Type
low complexity region	7	21	N/A	INTRINSIC
low complexity region	29	60	N/A	INTRINSIC
low complexity region	63	108	N/A	INTRINSIC
low complexity region	119	146	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the syndecan proteoglycan family. It may play a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. Allelic variants of this gene have been associated with obesity. [provided by RefSeq, Oct 2009]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit enhanced long-term potentiation and impaired hippocampus-dependent memory. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933427I04Rik	A	T	4: 123,754,338 (GRCm39)	K84M	probably damaging	Het
A4gnt	T	A	9: 99,502,489 (GRCm39)	Y216*	probably null	Het
Abcb1b	A	G	5: 8,875,293 (GRCm39)		probably benign	Het
Ankrd50	G	A	3: 38,506,563 (GRCm39)		probably benign	Het
Catsperb	A	G	12: 101,381,584 (GRCm39)	T89A	probably benign	Het
Ccdc15	C	T	9: 37,227,786 (GRCm39)	S236N	probably benign	Het
Cd34	A	C	1: 194,631,816 (GRCm39)	T151P	possibly damaging	Het
Col28a1	A	T	6: 8,014,810 (GRCm39)	V865E	probably damaging	Het
Csf2rb	T	A	15: 78,232,304 (GRCm39)	V537E	probably damaging	Het
Cux2	A	G	5: 122,011,777 (GRCm39)	F553L	probably damaging	Het
Dolk	A	T	2: 30,174,743 (GRCm39)	L434Q	probably damaging	Het
Dsg2	C	A	18: 20,715,824 (GRCm39)	D255E	probably damaging	Het
Endov	T	C	11: 119,391,444 (GRCm39)	V144A	probably damaging	Het
Grik2	T	C	10: 49,232,034 (GRCm39)	N499D	probably damaging	Het
Hephl1	G	T	9: 14,978,341 (GRCm39)	T855K	probably benign	Het
Hif1a	A	G	12: 73,988,784 (GRCm39)	D557G	probably damaging	Het
Idh1	G	A	1: 65,210,308 (GRCm39)	T75I	probably damaging	Het
Ighv1-37	A	G	12: 114,860,070 (GRCm39)	S47P	probably benign	Het
Irx4	A	G	13: 73,416,341 (GRCm39)		probably benign	Het
Itpr1	C	T	6: 108,448,081 (GRCm39)	A1871V	probably damaging	Het
Klkb1	A	G	8: 45,747,105 (GRCm39)		probably benign	Het
Lrrc8e	T	C	8: 4,285,080 (GRCm39)	L435P	probably damaging	Het
Megf11	T	A	9: 64,416,009 (GRCm39)	Y73N	probably damaging	Het
Nfe2	T	C	15: 103,157,607 (GRCm39)	D128G	probably damaging	Het
Or13a22	A	G	7: 140,072,614 (GRCm39)	E21G	probably benign	Het
Or4k51	T	A	2: 111,584,771 (GRCm39)	M59K	probably damaging	Het
Pak6	C	A	2: 118,526,963 (GRCm39)	L653I	probably damaging	Het
Pde4dip	T	A	3: 97,655,074 (GRCm39)		probably benign	Het
Pds5a	A	G	5: 65,789,066 (GRCm39)	V831A	probably benign	Het
Prc1	G	T	7: 79,957,444 (GRCm39)		probably null	Het
Ptprs	C	T	17: 56,765,243 (GRCm39)	G14S	probably damaging	Het
Pygb	A	G	2: 150,661,833 (GRCm39)	K520E	probably benign	Het
Rimbp2	A	G	5: 128,883,505 (GRCm39)	S92P	probably benign	Het
Samd4b	A	T	7: 28,113,638 (GRCm39)	L109Q	probably damaging	Het
Saxo4	T	C	19: 10,451,863 (GRCm39)	*428W	probably null	Het
Scn8a	A	T	15: 100,853,287 (GRCm39)		probably benign	Het
Sec61a2	A	G	2: 5,876,831 (GRCm39)	Y350H	possibly damaging	Het
Slc4a3	A	T	1: 75,530,891 (GRCm39)	Q759L	probably damaging	Het
Speg	C	T	1: 75,387,378 (GRCm39)	P1378L	probably damaging	Het
Spta1	T	G	1: 174,035,956 (GRCm39)	Y1087*	probably null	Het
Tenm4	A	G	7: 96,378,598 (GRCm39)	E401G	probably damaging	Het
Tom1	C	A	8: 75,781,331 (GRCm39)		probably benign	Het
Ttc3	T	A	16: 94,257,577 (GRCm39)	V1273D	probably damaging	Het
Vmn2r106	G	T	17: 20,497,837 (GRCm39)	D467E	possibly damaging	Het
Washc4	A	T	10: 83,386,747 (GRCm39)	T124S	probably benign	Het
Zfp790	A	G	7: 29,529,034 (GRCm39)	E573G	probably benign	Het

Other mutations in Sdc3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01715:Sdc3	APN	4	130,546,378 (GRCm39)	missense	probably damaging	0.99
IGL02160:Sdc3	APN	4	130,545,886 (GRCm39)	splice site	probably benign
IGL03134:Sdc3	UTSW	4	130,548,815 (GRCm39)	missense	probably benign	0.00
R2426:Sdc3	UTSW	4	130,546,114 (GRCm39)	missense	unknown
R4678:Sdc3	UTSW	4	130,545,907 (GRCm39)	utr 5 prime	probably benign
R4779:Sdc3	UTSW	4	130,546,376 (GRCm39)	missense	probably damaging	0.99
R4786:Sdc3	UTSW	4	130,550,079 (GRCm39)	missense	probably damaging	0.97
R5182:Sdc3	UTSW	4	130,548,995 (GRCm39)	unclassified	probably benign
R5225:Sdc3	UTSW	4	130,546,087 (GRCm39)	missense	unknown
R6111:Sdc3	UTSW	4	130,546,153 (GRCm39)	missense	unknown
R6980:Sdc3	UTSW	4	130,544,233 (GRCm39)	utr 5 prime	probably benign
R7881:Sdc3	UTSW	4	130,544,244 (GRCm39)	missense	unknown
R7920:Sdc3	UTSW	4	130,546,507 (GRCm39)	missense	probably benign	0.00
R8514:Sdc3	UTSW	4	130,546,072 (GRCm39)	missense	unknown
R8815:Sdc3	UTSW	4	130,546,336 (GRCm39)	missense	probably benign	0.18
R8909:Sdc3	UTSW	4	130,546,094 (GRCm39)	missense	unknown
R9116:Sdc3	UTSW	4	130,546,352 (GRCm39)	missense	probably benign	0.33
R9251:Sdc3	UTSW	4	130,548,513 (GRCm39)	unclassified	probably benign
R9764:Sdc3	UTSW	4	130,546,048 (GRCm39)	missense	unknown

Posted On

2013-04-17