Incidental Mutation 'R5182:Sdc3'
ID 397599
Institutional Source Beutler Lab
Gene Symbol Sdc3
Ensembl Gene ENSMUSG00000025743
Gene Name syndecan 3
Synonyms syn-3, Synd3
MMRRC Submission 042853-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.135) question?
Stock # R5182 (G1)
Quality Score 222
Status Validated
Chromosome 4
Chromosomal Location 130519848-130553629 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to G at 130548995 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000118685 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070478] [ENSMUST00000141297] [ENSMUST00000152591]
AlphaFold Q64519
Predicted Effect probably benign
Transcript: ENSMUST00000070478
SMART Domains Protein: ENSMUSP00000065877
Gene: ENSMUSG00000025743

DomainStartEndE-ValueType
signal peptide 1 44 N/A INTRINSIC
low complexity region 60 76 N/A INTRINSIC
low complexity region 101 115 N/A INTRINSIC
low complexity region 123 154 N/A INTRINSIC
low complexity region 157 202 N/A INTRINSIC
low complexity region 213 240 N/A INTRINSIC
low complexity region 276 287 N/A INTRINSIC
low complexity region 330 341 N/A INTRINSIC
4.1m 408 426 2.51e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140623
Predicted Effect probably benign
Transcript: ENSMUST00000141297
SMART Domains Protein: ENSMUSP00000123608
Gene: ENSMUSG00000025743

DomainStartEndE-ValueType
low complexity region 7 21 N/A INTRINSIC
low complexity region 29 60 N/A INTRINSIC
low complexity region 63 108 N/A INTRINSIC
low complexity region 119 146 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146093
Predicted Effect probably benign
Transcript: ENSMUST00000152591
SMART Domains Protein: ENSMUSP00000118685
Gene: ENSMUSG00000025743

DomainStartEndE-ValueType
low complexity region 7 21 N/A INTRINSIC
low complexity region 29 60 N/A INTRINSIC
low complexity region 63 108 N/A INTRINSIC
low complexity region 119 146 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181227
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency 100% (66/66)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the syndecan proteoglycan family. It may play a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. Allelic variants of this gene have been associated with obesity. [provided by RefSeq, Oct 2009]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit enhanced long-term potentiation and impaired hippocampus-dependent memory. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110059E24Rik A G 19: 21,608,129 (GRCm39) M1T probably null Het
Abcg8 T C 17: 85,000,172 (GRCm39) L243P probably damaging Het
Ankrd27 A G 7: 35,327,912 (GRCm39) T811A probably damaging Het
Auts2 T C 5: 131,503,919 (GRCm39) N188S probably null Het
Bak1 G A 17: 27,241,722 (GRCm39) P65L possibly damaging Het
Cep350 A C 1: 155,733,854 (GRCm39) L3013R probably damaging Het
Clca3b A G 3: 144,533,776 (GRCm39) I533T probably damaging Het
Col6a5 C A 9: 105,734,531 (GRCm39) E2637* probably null Het
Coq5 G A 5: 115,417,815 (GRCm39) R15H probably benign Het
Dnah5 T G 15: 28,311,424 (GRCm39) I1801S probably damaging Het
Dnhd1 G A 7: 105,352,416 (GRCm39) R2523Q probably damaging Het
Dpf3 T C 12: 83,417,370 (GRCm39) E34G probably damaging Het
Dst C A 1: 34,218,167 (GRCm39) Q1536K probably benign Het
Eeig2 T C 3: 108,892,667 (GRCm39) K173E possibly damaging Het
Eng T C 2: 32,562,971 (GRCm39) probably null Het
Fignl1 A T 11: 11,751,717 (GRCm39) I446N probably damaging Het
Fras1 C A 5: 96,784,032 (GRCm39) C845* probably null Het
Gfm2 T C 13: 97,299,401 (GRCm39) V347A probably damaging Het
Gpld1 A T 13: 25,168,053 (GRCm39) probably null Het
Grn C A 11: 102,321,380 (GRCm39) probably benign Het
Gsdmc4 C A 15: 63,765,653 (GRCm39) V299F probably damaging Het
Hrnr A T 3: 93,239,450 (GRCm39) R3229S unknown Het
Icam5 A G 9: 20,946,106 (GRCm39) T313A probably benign Het
Ift172 T A 5: 31,424,958 (GRCm39) D668V possibly damaging Het
Kdm5a T A 6: 120,365,066 (GRCm39) C322* probably null Het
Klk6 A G 7: 43,478,084 (GRCm39) K152R probably benign Het
Man1a2 A C 3: 100,554,333 (GRCm39) I250S probably damaging Het
Nkpd1 A G 7: 19,257,181 (GRCm39) Y170C probably damaging Het
Nmd3 T A 3: 69,629,801 (GRCm39) probably null Het
Or2y3 A G 17: 38,393,005 (GRCm39) M288T probably benign Het
Or51f1 A T 7: 102,506,176 (GRCm39) D104E probably benign Het
Pax4 C T 6: 28,444,368 (GRCm39) E229K probably benign Het
Pdc T C 1: 150,209,105 (GRCm39) I196T possibly damaging Het
Pld1 T C 3: 28,099,230 (GRCm39) I299T probably damaging Het
Pnma1 T C 12: 84,193,819 (GRCm39) I295V probably benign Het
Prkg2 T A 5: 99,172,568 (GRCm39) Y49F probably benign Het
Psmd12 T C 11: 107,370,485 (GRCm39) L28P probably damaging Het
Ptprg A G 14: 12,154,174 (GRCm38) T632A probably benign Het
Rab43 A G 6: 87,771,637 (GRCm39) *118R probably null Het
Rabep1 C T 11: 70,795,454 (GRCm39) R227* probably null Het
Rad51c T G 11: 87,288,545 (GRCm39) I213L possibly damaging Het
Ranbp17 A T 11: 33,169,287 (GRCm39) probably benign Het
Ryr3 T C 2: 112,585,495 (GRCm39) E2735G probably damaging Het
Sirpa G A 2: 129,457,652 (GRCm39) R242H possibly damaging Het
Slc12a4 G A 8: 106,671,238 (GRCm39) T983M probably damaging Het
Snx7 A G 3: 117,626,506 (GRCm39) Y252H probably damaging Het
St18 C T 1: 6,887,877 (GRCm39) T482I probably benign Het
St7 A G 6: 17,846,236 (GRCm39) Y163C probably damaging Het
Tas2r140 A T 6: 40,468,866 (GRCm39) Q232L probably benign Het
Tgm6 A T 2: 129,983,222 (GRCm39) K270N probably damaging Het
Tiam2 G A 17: 3,488,996 (GRCm39) G768D probably damaging Het
Ttn C T 2: 76,700,773 (GRCm39) probably benign Het
Ube4b A C 4: 149,465,699 (GRCm39) S250R probably null Het
Ubxn2a G A 12: 4,930,634 (GRCm39) A242V probably damaging Het
Usp10 G A 8: 120,683,420 (GRCm39) V764I possibly damaging Het
Vmn1r222 A G 13: 23,416,667 (GRCm39) L182P probably damaging Het
Vmn2r114 A G 17: 23,510,632 (GRCm39) V616A probably damaging Het
Vps13a A G 19: 16,672,863 (GRCm39) V1303A possibly damaging Het
Wnk2 G T 13: 49,214,637 (GRCm39) T1315K possibly damaging Het
Zfp936 G A 7: 42,839,331 (GRCm39) C266Y probably damaging Het
Zscan20 G T 4: 128,480,504 (GRCm39) N662K possibly damaging Het
Other mutations in Sdc3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00979:Sdc3 APN 4 130,545,991 (GRCm39) missense unknown
IGL01715:Sdc3 APN 4 130,546,378 (GRCm39) missense probably damaging 0.99
IGL02160:Sdc3 APN 4 130,545,886 (GRCm39) splice site probably benign
IGL03134:Sdc3 UTSW 4 130,548,815 (GRCm39) missense probably benign 0.00
R2426:Sdc3 UTSW 4 130,546,114 (GRCm39) missense unknown
R4678:Sdc3 UTSW 4 130,545,907 (GRCm39) utr 5 prime probably benign
R4779:Sdc3 UTSW 4 130,546,376 (GRCm39) missense probably damaging 0.99
R4786:Sdc3 UTSW 4 130,550,079 (GRCm39) missense probably damaging 0.97
R5225:Sdc3 UTSW 4 130,546,087 (GRCm39) missense unknown
R6111:Sdc3 UTSW 4 130,546,153 (GRCm39) missense unknown
R6980:Sdc3 UTSW 4 130,544,233 (GRCm39) utr 5 prime probably benign
R7881:Sdc3 UTSW 4 130,544,244 (GRCm39) missense unknown
R7920:Sdc3 UTSW 4 130,546,507 (GRCm39) missense probably benign 0.00
R8514:Sdc3 UTSW 4 130,546,072 (GRCm39) missense unknown
R8815:Sdc3 UTSW 4 130,546,336 (GRCm39) missense probably benign 0.18
R8909:Sdc3 UTSW 4 130,546,094 (GRCm39) missense unknown
R9116:Sdc3 UTSW 4 130,546,352 (GRCm39) missense probably benign 0.33
R9251:Sdc3 UTSW 4 130,548,513 (GRCm39) unclassified probably benign
R9764:Sdc3 UTSW 4 130,546,048 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TTCAAGAAGAGACCACGCAG -3'
(R):5'- AGGTCGGAGATTAGCACCTAG -3'

Sequencing Primer
(F):5'- CACGGCCAATGAGGTGGTG -3'
(R):5'- TTAGCACCTAGGAAGAAAGGTCCC -3'
Posted On 2016-07-06