Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00928:Or10s1'

28169

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or10s1

Ensembl Gene

ENSMUSG00000049010

Gene Name

olfactory receptor family 10 subfamily S member 1

Synonyms

Olfr982, GA_x6K02T2PVTD-33772307-33773260, MOR223-4

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.112) question?

Stock #

IGL00928

Quality Score

Status

Chromosome

Chromosomal Location

39985593-39986558 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 39986072 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Glutamine at position 160 (H160Q)

Ref Sequence

ENSEMBL: ENSMUSP00000052705 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054051]

AlphaFold

Q8VGB3

Predicted Effect

probably damaging
Transcript: ENSMUST00000054051
AA Change: H160Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000052705
Gene: ENSMUSG00000049010
AA Change: H160Q

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	311	4.2e-48	PFAM
Pfam:7tm_1	45	293	6.7e-24	PFAM
low complexity region	314	321	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc5	A	T	16: 20,217,720 (GRCm39)		probably benign	Het
Ablim3	T	C	18: 61,982,477 (GRCm39)	E156G	possibly damaging	Het
Adgrb2	A	G	4: 129,886,096 (GRCm39)	T79A	probably benign	Het
Arel1	A	T	12: 84,980,936 (GRCm39)	V357E	probably damaging	Het
Asph	T	C	4: 9,594,675 (GRCm39)	I241V	probably benign	Het
B3galt2	A	G	1: 143,522,893 (GRCm39)	Y343C	probably damaging	Het
Brf1	A	G	12: 112,927,220 (GRCm39)		probably benign	Het
Col3a1	A	G	1: 45,380,018 (GRCm39)		probably benign	Het
Cps1	A	C	1: 67,162,393 (GRCm39)	T24P	probably benign	Het
Cyp3a25	A	G	5: 145,923,764 (GRCm39)	L293P	possibly damaging	Het
Engase	C	A	11: 118,373,796 (GRCm39)	R313S	possibly damaging	Het
Espn	A	G	4: 152,220,059 (GRCm39)	S28P	probably damaging	Het
Gnas	T	A	2: 174,139,746 (GRCm39)	L31*	probably null	Het
Gorasp2	A	G	2: 70,521,208 (GRCm39)	T393A	probably benign	Het
Gpc6	T	A	14: 117,163,370 (GRCm39)	V8E	possibly damaging	Het
Gtf2a1l	T	C	17: 89,001,890 (GRCm39)	S202P	probably benign	Het
Gucy1a2	T	C	9: 3,759,777 (GRCm39)	F528L	probably damaging	Het
Hnrnpm	C	A	17: 33,868,876 (GRCm39)	R517L	probably damaging	Het
Igsf10	T	C	3: 59,238,018 (GRCm39)	H721R	probably benign	Het
Kcnu1	T	C	8: 26,339,763 (GRCm39)	F27S	probably damaging	Het
Mprip	T	A	11: 59,635,578 (GRCm39)	W366R	probably damaging	Het
Myom1	T	C	17: 71,396,908 (GRCm39)	V954A	probably damaging	Het
Nudt13	T	C	14: 20,366,231 (GRCm39)	I303T	possibly damaging	Het
Or2h1	A	C	17: 37,404,224 (GRCm39)	S181A	probably benign	Het
Orc4	A	G	2: 48,800,281 (GRCm39)	V289A	probably benign	Het
Pamr1	C	A	2: 102,469,686 (GRCm39)	Q411K	probably benign	Het
Pdcl	A	G	2: 37,247,386 (GRCm39)	M1T	probably null	Het
Phf20	T	C	2: 156,146,736 (GRCm39)		probably null	Het
Pla2r1	T	C	2: 60,365,424 (GRCm39)	S49G	probably damaging	Het
Ppp2r3c	A	G	12: 55,339,283 (GRCm39)		probably null	Het
Rdh14	G	A	12: 10,444,803 (GRCm39)	S218N	probably damaging	Het
Rfx4	A	G	10: 84,675,978 (GRCm39)	R16G	probably benign	Het
Scarb2	A	C	5: 92,594,203 (GRCm39)	F453C	probably damaging	Het
Sh2d7	A	G	9: 54,448,515 (GRCm39)	T179A	probably benign	Het
Spag6l	C	T	16: 16,584,877 (GRCm39)	A424T	possibly damaging	Het
Trim71	T	C	9: 114,354,083 (GRCm39)	D307G	probably benign	Het
Ufl1	A	T	4: 25,267,790 (GRCm39)	L294M	probably damaging	Het
Wdr93	C	A	7: 79,425,301 (GRCm39)	P540Q	probably damaging	Het
Wmp	T	A	X: 106,989,449 (GRCm39)	E488V	possibly damaging	Het

Other mutations in Or10s1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02095:Or10s1	APN	9	39,985,967 (GRCm39)	nonsense	probably null
IGL02160:Or10s1	APN	9	39,986,482 (GRCm39)	missense	probably damaging	1.00
R0277:Or10s1	UTSW	9	39,986,010 (GRCm39)	missense	probably benign	0.05
R1241:Or10s1	UTSW	9	39,986,192 (GRCm39)	missense	probably damaging	1.00
R1344:Or10s1	UTSW	9	39,985,768 (GRCm39)	missense	probably damaging	1.00
R1418:Or10s1	UTSW	9	39,985,768 (GRCm39)	missense	probably damaging	1.00
R1838:Or10s1	UTSW	9	39,985,605 (GRCm39)	missense	probably benign
R1864:Or10s1	UTSW	9	39,986,081 (GRCm39)	missense	possibly damaging	0.88
R2165:Or10s1	UTSW	9	39,986,211 (GRCm39)	missense	possibly damaging	0.96
R3808:Or10s1	UTSW	9	39,985,605 (GRCm39)	missense	probably benign
R4633:Or10s1	UTSW	9	39,985,630 (GRCm39)	missense	probably damaging	1.00
R4988:Or10s1	UTSW	9	39,985,961 (GRCm39)	missense	probably damaging	0.99
R5569:Or10s1	UTSW	9	39,985,593 (GRCm39)	start codon destroyed	probably null	0.39
R6307:Or10s1	UTSW	9	39,985,824 (GRCm39)	missense	probably damaging	1.00
R6594:Or10s1	UTSW	9	39,986,239 (GRCm39)	missense	probably damaging	1.00
R6863:Or10s1	UTSW	9	39,986,110 (GRCm39)	missense	probably damaging	1.00
R7064:Or10s1	UTSW	9	39,986,109 (GRCm39)	missense	probably damaging	1.00
R7602:Or10s1	UTSW	9	39,986,455 (GRCm39)	missense	probably damaging	1.00
R8460:Or10s1	UTSW	9	39,986,353 (GRCm39)	missense	probably damaging	0.99
R9226:Or10s1	UTSW	9	39,986,187 (GRCm39)	missense	probably benign	0.00
R9544:Or10s1	UTSW	9	39,986,353 (GRCm39)	missense	probably damaging	0.99
R9588:Or10s1	UTSW	9	39,986,353 (GRCm39)	missense	probably damaging	0.99

Posted On

2013-04-17