Incidental Mutation 'IGL02298:Gm8890'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm8890
Ensembl Gene ENSMUSG00000096846
Gene Namepredicted gene 8890
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL02298
Quality Score
Chromosomal Location11256033-11260494 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 11257191 bp
Amino Acid Change Leucine to Arginine at position 12 (L12R)
Ref Sequence ENSEMBL: ENSMUSP00000136387 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000177727]
Predicted Effect unknown
Transcript: ENSMUST00000164262
AA Change: L14R
SMART Domains Protein: ENSMUSP00000127049
Gene: ENSMUSG00000096846
AA Change: L14R

Pfam:Takusan 6 92 4.6e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000177727
AA Change: L12R

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000136387
Gene: ENSMUSG00000096846
AA Change: L12R

Pfam:Takusan 2 90 4.2e-31 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197751
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 15 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4922502D21Rik T A 6: 129,331,564 M1L probably benign Het
Ahctf1 A G 1: 179,752,479 S2053P probably benign Het
Alkbh2 C T 5: 114,125,572 E125K probably benign Het
Cd226 A T 18: 89,207,051 D24V probably damaging Het
Dync1h1 G A 12: 110,640,888 E2638K probably damaging Het
Fbxw5 G A 2: 25,504,444 W143* probably null Het
Galk2 T C 2: 125,859,370 S5P probably benign Het
Gtf2h2 A G 13: 100,481,039 V205A probably damaging Het
Helb C A 10: 120,101,526 Q604H probably damaging Het
Ifih1 A G 2: 62,610,439 probably null Het
Map7d1 T C 4: 126,233,921 E675G unknown Het
Olfr912 C T 9: 38,581,513 P79S probably damaging Het
Shc4 T C 2: 125,649,154 H488R probably damaging Het
Zfhx4 G A 3: 5,244,304 probably null Het
Zfp451 A T 1: 33,772,921 N904K probably damaging Het
Other mutations in Gm8890
AlleleSourceChrCoordTypePredicted EffectPPH Score
R6214:Gm8890 UTSW 5 11257230 missense probably damaging 0.99
R6215:Gm8890 UTSW 5 11257230 missense probably damaging 0.99
R6511:Gm8890 UTSW 5 11257308 missense probably benign 0.09
Posted On2015-04-16