Incidental Mutation 'IGL02421:Olfr661'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr661
Ensembl Gene ENSMUSG00000073920
Gene Nameolfactory receptor 661
SynonymsMOR40-4, GA_x6K02T2PBJ9-7316375-7317334
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.114) question?
Stock #IGL02421
Quality Score
Chromosomal Location104686501-104691354 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 104688533 bp
Amino Acid Change Asparagine to Aspartic acid at position 173 (N173D)
Ref Sequence ENSEMBL: ENSMUSP00000151208 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098168] [ENSMUST00000214876]
Predicted Effect probably benign
Transcript: ENSMUST00000098168
AA Change: N173D

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000095770
Gene: ENSMUSG00000073920
AA Change: N173D

Pfam:7tm_4 37 314 5.9e-74 PFAM
Pfam:7TM_GPCR_Srsx 41 312 2e-9 PFAM
Pfam:7tm_1 47 297 1.1e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211165
Predicted Effect probably benign
Transcript: ENSMUST00000214876
AA Change: N173D

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215864
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
a T C 2: 155,050,752 F117S probably damaging Het
A930011G23Rik A G 5: 99,229,377 S404P probably damaging Het
A930011G23Rik G A 5: 99,229,382 P402L probably damaging Het
Acacb A G 5: 114,223,878 T1394A probably benign Het
Adam19 A G 11: 46,137,553 N671S probably damaging Het
Akap13 A T 7: 75,717,806 N1815I possibly damaging Het
Aloxe3 A G 11: 69,130,046 D199G possibly damaging Het
Ap1g2 G A 14: 55,102,402 A440V probably damaging Het
Bmt2 G T 6: 13,628,842 Q281K probably damaging Het
Celsr3 T C 9: 108,840,463 F2243L probably damaging Het
Cenpb G A 2: 131,179,681 R66C probably damaging Het
Chl1 A T 6: 103,717,580 H1121L probably damaging Het
Cpb1 T C 3: 20,251,984 Y344C probably damaging Het
Cspg5 T A 9: 110,247,392 probably benign Het
Dnah11 T C 12: 118,186,902 N374D probably damaging Het
Dnah3 A G 7: 119,950,992 V3368A possibly damaging Het
Eml4 T C 17: 83,477,892 S829P probably benign Het
Gm14548 T C 7: 3,896,995 N203D possibly damaging Het
Got2-ps1 T C 5: 138,364,549 noncoding transcript Het
Hal T C 10: 93,503,473 C475R probably damaging Het
Mapkbp1 C T 2: 120,019,655 P806S possibly damaging Het
Mmrn1 A T 6: 60,944,822 T88S probably benign Het
Napsa A G 7: 44,585,055 H237R probably damaging Het
Olfr1215 T C 2: 89,001,344 probably null Het
Olfr412 T C 11: 74,365,191 I174T probably damaging Het
Olfr568 T C 7: 102,877,759 I213T probably damaging Het
Opn5 C T 17: 42,596,555 probably benign Het
Polb C T 8: 22,640,373 G179D probably damaging Het
Primpol G T 8: 46,607,795 probably benign Het
Prom2 T A 2: 127,531,882 probably null Het
Psmb10 A G 8: 105,937,492 probably null Het
Ranbp2 T G 10: 58,480,554 S2365R probably damaging Het
Sgce G A 6: 4,694,187 probably benign Het
Slc25a34 A G 4: 141,621,442 V237A probably benign Het
Slc39a2 A T 14: 51,893,872 T25S probably benign Het
Smarca4 T C 9: 21,639,239 C423R probably damaging Het
Stt3b G A 9: 115,251,852 probably benign Het
Tbl1xr1 A T 3: 22,203,163 I397F probably damaging Het
Tie1 A G 4: 118,486,394 V117A probably damaging Het
Tmc3 T C 7: 83,622,744 F1035L probably benign Het
Trhde T A 10: 114,412,461 K944N probably damaging Het
Vmn1r54 G A 6: 90,269,151 A16T probably benign Het
Washc4 T A 10: 83,579,550 N801K probably damaging Het
Xylt2 A G 11: 94,667,762 Y523H possibly damaging Het
Znfx1 T C 2: 167,060,080 R5G probably damaging Het
Other mutations in Olfr661
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01161:Olfr661 APN 7 104688381 missense probably benign 0.00
IGL01578:Olfr661 APN 7 104688845 missense probably benign 0.01
IGL01595:Olfr661 APN 7 104688078 missense possibly damaging 0.78
IGL01732:Olfr661 APN 7 104688336 missense possibly damaging 0.64
IGL02086:Olfr661 APN 7 104688427 missense probably benign 0.38
IGL02874:Olfr661 APN 7 104688023 missense probably benign 0.16
IGL03120:Olfr661 APN 7 104688402 missense probably benign 0.28
R0735:Olfr661 UTSW 7 104688819 missense probably damaging 0.97
R1246:Olfr661 UTSW 7 104688164 missense possibly damaging 0.69
R1654:Olfr661 UTSW 7 104688213 missense probably benign 0.12
R1994:Olfr661 UTSW 7 104688483 missense probably benign 0.12
R3686:Olfr661 UTSW 7 104688392 missense probably benign 0.00
R5140:Olfr661 UTSW 7 104688900 missense probably benign 0.01
R5627:Olfr661 UTSW 7 104688170 missense probably benign 0.02
R6338:Olfr661 UTSW 7 104688171 missense possibly damaging 0.53
R8810:Olfr661 UTSW 7 104688180 missense probably damaging 0.97
R8954:Olfr661 UTSW 7 104688693 nonsense probably null
Posted On2015-04-16