Incidental Mutation 'IGL02735:Cd55b'
ID305635
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cd55b
Ensembl Gene ENSMUSG00000026401
Gene NameCD55 molecule, decay accelerating factor for complement B
SynonymsDaf2, TM-DAF, complement-transmembrane, Daf-TM
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02735
Quality Score
Status
Chromosome1
Chromosomal Location130388537-130423009 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 130388676 bp
ZygosityHeterozygous
Amino Acid Change Tryptophan to Arginine at position 379 (W379R)
Ref Sequence ENSEMBL: ENSMUSP00000108107 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112488] [ENSMUST00000119432]
Predicted Effect probably damaging
Transcript: ENSMUST00000112488
AA Change: W379R

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000108107
Gene: ENSMUSG00000026401
AA Change: W379R

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
CCP 34 92 2.21e-12 SMART
CCP 96 156 1.47e-8 SMART
CCP 161 218 1.56e-12 SMART
CCP 223 282 2.19e-16 SMART
low complexity region 287 298 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000119432
AA Change: W266R

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000113352
Gene: ENSMUSG00000026401
AA Change: W266R

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
CCP 34 92 2.21e-12 SMART
CCP 96 156 1.47e-8 SMART
CCP 161 218 1.56e-12 SMART
transmembrane domain 247 269 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation. This gene is located adjacent to a closely related gene on chromosome 1 and preferentially expressed in the spleen and testis. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2015]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930011G23Rik A G 5: 99,229,377 S404P probably damaging Het
A930011G23Rik G A 5: 99,229,382 P402L probably damaging Het
Acss1 A T 2: 150,638,467 V228E probably damaging Het
Ampd1 T A 3: 103,085,377 M145K probably damaging Het
Ankhd1 G A 18: 36,648,546 S2217N probably benign Het
Asph T A 4: 9,598,759 D211V probably damaging Het
C87414 G A 5: 93,638,644 P89S possibly damaging Het
Derl3 A G 10: 75,895,116 T201A probably damaging Het
Efcab6 A G 15: 83,899,697 L1008P probably damaging Het
Eif4g3 A G 4: 138,126,211 I363V probably benign Het
Heatr5a A G 12: 51,915,021 F1058L probably damaging Het
Hmcn1 A T 1: 150,646,832 M3439K probably benign Het
Ift140 C A 17: 25,034,035 probably benign Het
Itgad A G 7: 128,193,716 Y832C probably damaging Het
Itgb2 T A 10: 77,549,999 D265E possibly damaging Het
Kif19a A T 11: 114,785,567 E449V probably damaging Het
Krt40 T C 11: 99,538,635 E291G probably damaging Het
Lama2 T C 10: 27,104,128 N1897S probably damaging Het
Lepr A G 4: 101,782,638 Y767C probably damaging Het
Lrrtm4 A G 6: 80,809,050 H546R probably benign Het
March6 A G 15: 31,486,120 S362P probably benign Het
Med12l A G 3: 59,093,646 Y734C probably damaging Het
Mrps18a C T 17: 46,122,799 R74C probably damaging Het
Mvk A G 5: 114,450,819 E174G probably benign Het
Naip2 A G 13: 100,160,214 S1105P probably damaging Het
Nrxn3 A G 12: 89,254,854 M468V probably benign Het
Obscn T C 11: 59,093,349 E1760G probably damaging Het
Pcsk5 C A 19: 17,675,468 G285W probably damaging Het
Pgpep1l A G 7: 68,236,973 I196T probably benign Het
Phf14 T C 6: 11,987,612 M630T probably benign Het
Plod2 T C 9: 92,595,389 probably benign Het
Poldip2 G A 11: 78,512,336 A9T probably benign Het
Pou2f1 A G 1: 165,875,827 S718P probably damaging Het
Ptpre A T 7: 135,667,567 Y246F probably damaging Het
Pudp T C 18: 50,568,332 H110R probably benign Het
Scaf4 C T 16: 90,245,515 G646E unknown Het
Sec16a T A 2: 26,428,137 probably benign Het
Serpina5 A G 12: 104,103,857 T338A probably benign Het
Shisa5 T G 9: 109,056,012 F118V probably damaging Het
Slc6a21 G A 7: 45,286,637 probably benign Het
Sprtn T A 8: 124,903,387 V473E probably benign Het
Styxl1 A G 5: 135,759,142 I165T probably damaging Het
Tal2 T A 4: 53,785,906 I29N probably damaging Het
Tas2r134 T C 2: 51,627,827 I106T probably damaging Het
Tmem259 G A 10: 79,979,139 T217I probably damaging Het
Trpc6 T C 9: 8,655,338 I723T probably damaging Het
Vmn1r211 A T 13: 22,852,248 V83D probably damaging Het
Vmn2r103 G T 17: 19,812,248 M761I probably benign Het
Ybey A T 10: 76,468,326 I14N probably damaging Het
Other mutations in Cd55b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01151:Cd55b APN 1 130422906 missense possibly damaging 0.86
IGL02086:Cd55b APN 1 130418182 missense probably benign 0.05
IGL02629:Cd55b APN 1 130419798 splice site probably benign
IGL03212:Cd55b APN 1 130411442 missense probably benign 0.15
R0827:Cd55b UTSW 1 130414236 missense probably damaging 0.96
R0961:Cd55b UTSW 1 130414076 missense probably damaging 1.00
R1381:Cd55b UTSW 1 130419675 missense probably damaging 1.00
R1762:Cd55b UTSW 1 130388655 nonsense probably null
R1839:Cd55b UTSW 1 130414105 missense probably damaging 1.00
R1940:Cd55b UTSW 1 130418106 critical splice donor site probably null
R2359:Cd55b UTSW 1 130418121 missense probably damaging 1.00
R2504:Cd55b UTSW 1 130409875 missense probably damaging 1.00
R4282:Cd55b UTSW 1 130416859 missense probably damaging 0.99
R6276:Cd55b UTSW 1 130418166 missense probably damaging 1.00
R6306:Cd55b UTSW 1 130414066 missense probably damaging 0.99
R6977:Cd55b UTSW 1 130419791 missense probably damaging 0.96
R7026:Cd55b UTSW 1 130388690 missense probably benign 0.06
R7528:Cd55b UTSW 1 130419736 missense possibly damaging 0.95
Posted On2015-04-16