Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02818:Csnk2a1'

360897

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Csnk2a1

Ensembl Gene

ENSMUSG00000074698

Gene Name

casein kinase 2, alpha 1 polypeptide

Synonyms

CK2, Csnk2a1-rs4

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL02818

Quality Score

Status

Chromosome

Chromosomal Location

152068759-152123772 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

G to T at 152116005 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000096829 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099224]

AlphaFold

Q60737

Predicted Effect

probably benign
Transcript: ENSMUST00000099224

SMART Domains

Protein: ENSMUSP00000096829
Gene: ENSMUSG00000074698

Domain	Start	End	E-Value	Type
S_TKc	39	324	1.88e-78	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136063

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014]
PHENOTYPE: Mice homozygous for the null in the major catalytic subunit die by E11.5 and exhibit defects in neural, cardiac and limb development. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca17	A	G	17: 24,519,326 (GRCm39)	F653S	probably benign	Het
Acsm2	A	G	7: 119,172,804 (GRCm39)		probably null	Het
Aldh2	C	T	5: 121,713,188 (GRCm39)	G256D	probably benign	Het
Ankfn1	G	A	11: 89,429,292 (GRCm39)	H31Y	probably benign	Het
BC016579	A	T	16: 45,449,865 (GRCm39)	S184R	probably damaging	Het
Cd101	A	G	3: 100,919,245 (GRCm39)	L619P	probably damaging	Het
Clec14a	A	T	12: 58,314,888 (GRCm39)	C245S	probably damaging	Het
Csmd2	T	C	4: 128,103,521 (GRCm39)	C247R	probably damaging	Het
Dctn1	T	C	6: 83,169,496 (GRCm39)	S637P	possibly damaging	Het
Dhx40	A	T	11: 86,690,331 (GRCm39)	I230K	probably benign	Het
Dnah7b	T	C	1: 46,329,968 (GRCm39)	Y3271H	probably damaging	Het
Efcab5	A	T	11: 76,996,174 (GRCm39)	I1129N	probably damaging	Het
Gaa	G	T	11: 119,167,674 (GRCm39)	A445S	probably damaging	Het
Gldc	A	G	19: 30,113,909 (GRCm39)	S498P	probably damaging	Het
Gm973	T	C	1: 59,580,634 (GRCm39)		probably null	Het
Hpdl	T	C	4: 116,677,439 (GRCm39)	I341V	probably damaging	Het
Il23r	A	G	6: 67,463,078 (GRCm39)		probably null	Het
Kif9	T	A	9: 110,314,217 (GRCm39)	Y76N	probably damaging	Het
Lct	T	G	1: 128,227,905 (GRCm39)	E1196A	probably damaging	Het
Lrrc37a	T	C	11: 103,392,132 (GRCm39)	I1098V	possibly damaging	Het
Mroh1	A	G	15: 76,316,601 (GRCm39)		probably null	Het
Nmrk1	T	C	19: 18,618,623 (GRCm39)	L102P	probably damaging	Het
Nudcd3	A	T	11: 6,100,635 (GRCm39)		probably benign	Het
Ogdh	A	G	11: 6,298,270 (GRCm39)	T603A	probably benign	Het
Or12j2	A	T	7: 139,916,519 (GRCm39)	Y248F	possibly damaging	Het
Or8k38	T	A	2: 86,488,128 (GRCm39)	I225F	probably damaging	Het
Pcsk4	T	C	10: 80,158,626 (GRCm39)	Y542C	probably damaging	Het
Pkd2l2	T	A	18: 34,545,862 (GRCm39)	W88R	probably damaging	Het
Ppp1r1b	C	T	11: 98,242,096 (GRCm39)	T21I	possibly damaging	Het
Srebf2	C	A	15: 82,069,575 (GRCm39)	H706N	probably damaging	Het
Stradb	T	C	1: 59,019,121 (GRCm39)	V14A	probably damaging	Het
Svep1	T	C	4: 58,069,804 (GRCm39)	T2661A	possibly damaging	Het
Tnn	A	T	1: 159,943,848 (GRCm39)	S988R	possibly damaging	Het
Trpm6	C	A	19: 18,843,621 (GRCm39)	Q1662K	probably benign	Het
Utp3	T	A	5: 88,703,267 (GRCm39)	Y265*	probably null	Het
Vwf	A	G	6: 125,640,511 (GRCm39)	T2316A	probably benign	Het
Zfp90	T	C	8: 107,150,841 (GRCm39)	F185L	probably benign	Het
Zwilch	G	A	9: 64,057,509 (GRCm39)	T395I	probably damaging	Het

Other mutations in Csnk2a1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01571:Csnk2a1	APN	2	152,117,326 (GRCm39)	missense	probably damaging	1.00
IGL02003:Csnk2a1	APN	2	152,118,890 (GRCm39)	nonsense	probably null
IGL02043:Csnk2a1	APN	2	152,116,070 (GRCm39)	missense	probably damaging	1.00
IGL02803:Csnk2a1	APN	2	152,116,005 (GRCm39)	splice site	probably benign
IGL02815:Csnk2a1	APN	2	152,116,005 (GRCm39)	splice site	probably benign
IGL02819:Csnk2a1	APN	2	152,116,005 (GRCm39)	splice site	probably benign
R1454:Csnk2a1	UTSW	2	152,099,347 (GRCm39)	missense	probably damaging	1.00
R1725:Csnk2a1	UTSW	2	152,099,892 (GRCm39)	missense	probably damaging	0.98
R2086:Csnk2a1	UTSW	2	152,096,201 (GRCm39)	missense	probably benign	0.01
R3113:Csnk2a1	UTSW	2	152,105,134 (GRCm39)	missense	probably damaging	1.00
R4003:Csnk2a1	UTSW	2	152,092,495 (GRCm39)	missense	probably damaging	0.97
R4021:Csnk2a1	UTSW	2	152,100,609 (GRCm39)	missense	probably damaging	0.96
R6702:Csnk2a1	UTSW	2	152,100,608 (GRCm39)	missense	probably benign	0.35
R6703:Csnk2a1	UTSW	2	152,100,608 (GRCm39)	missense	probably benign	0.35
R6849:Csnk2a1	UTSW	2	152,092,484 (GRCm39)	missense	probably benign
R7021:Csnk2a1	UTSW	2	152,102,732 (GRCm39)	missense	probably damaging	1.00
R7061:Csnk2a1	UTSW	2	152,116,091 (GRCm39)	missense	probably benign	0.08
R7381:Csnk2a1	UTSW	2	152,100,614 (GRCm39)	missense	probably benign	0.05
R8799:Csnk2a1	UTSW	2	152,099,886 (GRCm39)	missense	probably damaging	1.00
R8990:Csnk2a1	UTSW	2	152,096,177 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-12-18