Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03129:Prss3l'

410239

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prss3l

Ensembl Gene

ENSMUSG00000071517

Gene Name

serine protease 3 like

Synonyms

Gm10334

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.111) question?

Stock #

IGL03129

Quality Score

Status

Chromosome

Chromosomal Location

41419150-41423079 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 41420432 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 98 (N98S)

Ref Sequence

ENSEMBL: ENSMUSP00000093698 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095999]

AlphaFold

Q792Y8

Predicted Effect

probably benign
Transcript: ENSMUST00000095999
AA Change: N98S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000093698
Gene: ENSMUSG00000071517
AA Change: N98S

Domain	Start	End	E-Value	Type
Tryp_SPc	23	239	2.6e-105	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A930011G23Rik	A	G	5: 99,377,238 (GRCm39)	V403A	probably damaging	Het
Adpgk	T	C	9: 59,221,088 (GRCm39)	L298P	probably damaging	Het
Akap6	A	T	12: 53,187,089 (GRCm39)	D1501V	probably damaging	Het
Ank2	C	A	3: 126,749,519 (GRCm39)	E503D	probably damaging	Het
Ankhd1	T	A	18: 36,791,061 (GRCm39)	Y2478*	probably null	Het
Col6a3	A	G	1: 90,749,584 (GRCm39)	Y417H	probably damaging	Het
Csmd1	A	G	8: 16,011,521 (GRCm39)	F2511L	probably damaging	Het
Dzip3	T	C	16: 48,762,446 (GRCm39)	M602V	possibly damaging	Het
Efna2	G	A	10: 80,024,346 (GRCm39)		probably null	Het
Fzd8	T	C	18: 9,214,270 (GRCm39)	S451P	probably damaging	Het
Galntl6	A	T	8: 58,880,750 (GRCm39)	D134E	probably damaging	Het
Grid2	T	C	6: 64,040,888 (GRCm39)	S277P	probably damaging	Het
Lcn2	A	G	2: 32,277,716 (GRCm39)	V91A	possibly damaging	Het
Lrp1b	G	A	2: 41,202,478 (GRCm39)		probably benign	Het
Lrrc7	T	A	3: 157,866,696 (GRCm39)	Y1015F	probably benign	Het
Mdn1	T	A	4: 32,729,994 (GRCm39)	C2779S	possibly damaging	Het
Nlrp10	A	T	7: 108,524,118 (GRCm39)	F454Y	probably damaging	Het
Obox5	T	A	7: 15,492,684 (GRCm39)	L213Q	probably damaging	Het
Or1o2	T	A	17: 37,543,087 (GRCm39)	Y58F	probably damaging	Het
Piezo2	T	C	18: 63,248,043 (GRCm39)	M486V	probably benign	Het
Plcg1	A	C	2: 160,616,446 (GRCm39)		probably null	Het
Polr1b	G	A	2: 128,957,627 (GRCm39)	V561I	probably benign	Het
Polr3c	A	T	3: 96,626,770 (GRCm39)		probably benign	Het
Prkg1	T	A	19: 30,562,681 (GRCm39)	K523*	probably null	Het
Sema3b	T	A	9: 107,476,995 (GRCm39)		probably benign	Het
Sp9	A	G	2: 73,103,865 (GRCm39)	T140A	probably benign	Het
Zfp507	T	C	7: 35,493,631 (GRCm39)	R471G	probably damaging	Het

Other mutations in Prss3l

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01094:Prss3l	APN	6	41,420,357 (GRCm39)	missense	possibly damaging	0.91
R0379:Prss3l	UTSW	6	41,422,190 (GRCm39)	splice site	probably benign
R0387:Prss3l	UTSW	6	41,420,303 (GRCm39)	missense	possibly damaging	0.81
R0452:Prss3l	UTSW	6	41,422,271 (GRCm39)	missense	probably benign	0.30
R0647:Prss3l	UTSW	6	41,420,275 (GRCm39)	missense	probably benign
R4622:Prss3l	UTSW	6	41,422,246 (GRCm39)	missense	probably damaging	1.00
R4655:Prss3l	UTSW	6	41,422,984 (GRCm39)	missense	probably benign
R5340:Prss3l	UTSW	6	41,422,307 (GRCm39)	missense	probably benign	0.02
R6734:Prss3l	UTSW	6	41,422,321 (GRCm39)	missense	probably damaging	1.00
R9026:Prss3l	UTSW	6	41,422,990 (GRCm39)	missense	probably benign
R9464:Prss3l	UTSW	6	41,420,486 (GRCm39)	missense	probably benign	0.05

Posted On

2016-08-02