Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03215:Stk16'

413463

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Stk16

Ensembl Gene

ENSMUSG00000026201

Gene Name

serine/threonine kinase 16

Synonyms

EDPK, Embryo-Derived Protein Kinase, PKL12, Krct

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03215

Quality Score

Status

Chromosome

Chromosomal Location

75187482-75192250 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 75189236 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000139846 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027401] [ENSMUST00000113623] [ENSMUST00000123825] [ENSMUST00000186213] [ENSMUST00000155716] [ENSMUST00000185448] [ENSMUST00000144355] [ENSMUST00000191108] [ENSMUST00000189698] [ENSMUST00000188460] [ENSMUST00000186758] [ENSMUST00000189131] [ENSMUST00000190717] [ENSMUST00000188593]

AlphaFold

O88697

Predicted Effect

probably benign
Transcript: ENSMUST00000027401

SMART Domains

Protein: ENSMUSP00000027401
Gene: ENSMUSG00000026201

Domain	Start	End	E-Value	Type
Pfam:Pkinase	20	290	3.3e-47	PFAM
Pfam:Pkinase_Tyr	21	290	3e-28	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000079464

SMART Domains

Protein: ENSMUSP00000078429
Gene: ENSMUSG00000026202

Domain	Start	End	E-Value	Type
Tubulin	49	246	4.34e-79	SMART
Tubulin_C	248	393	7.88e-59	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000113623

SMART Domains

Protein: ENSMUSP00000109253
Gene: ENSMUSG00000026200

Domain	Start	End	E-Value	Type
low complexity region	5	19	N/A	INTRINSIC
Pfam:Glyco_hydro_35	34	351	4.1e-123	PFAM
Pfam:Glyco_hydro_42	48	209	6.6e-12	PFAM
low complexity region	355	371	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000123825

SMART Domains

Protein: ENSMUSP00000122688
Gene: ENSMUSG00000026201

Domain	Start	End	E-Value	Type
Pfam:Pkinase	20	122	9.1e-11	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000126328

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131408

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131738

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000142052

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000145144

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135484

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000132507

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000156012

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000186350

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000184844

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000139627

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000186492

Predicted Effect

probably benign
Transcript: ENSMUST00000186213

SMART Domains

Protein: ENSMUSP00000140657
Gene: ENSMUSG00000026202

Domain	Start	End	E-Value	Type
Tubulin	49	246	4.34e-79	SMART
Tubulin_C	248	393	7.88e-59	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000155716

SMART Domains

Protein: ENSMUSP00000136285
Gene: ENSMUSG00000026200

Domain	Start	End	E-Value	Type
low complexity region	5	19	N/A	INTRINSIC
Pfam:Glyco_hydro_35	34	351	4.2e-125	PFAM
Pfam:Glyco_hydro_42	48	209	6.6e-12	PFAM
low complexity region	355	371	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000185448

SMART Domains

Protein: ENSMUSP00000140820
Gene: ENSMUSG00000026200

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:Glyco_hydro_35	34	188	1.6e-71	PFAM
Pfam:Glyco_hydro_42	48	188	6.4e-10	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000186173

Predicted Effect

probably benign
Transcript: ENSMUST00000144355

SMART Domains

Protein: ENSMUSP00000115964
Gene: ENSMUSG00000026201

Domain	Start	End	E-Value	Type
Pfam:Pkinase	20	122	9.1e-11	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000191108

SMART Domains

Protein: ENSMUSP00000139846
Gene: ENSMUSG00000026201

Domain	Start	End	E-Value	Type
Pfam:Pkinase	20	186	8.6e-29	PFAM
Pfam:Pkinase_Tyr	21	184	2.1e-14	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000189698

SMART Domains

Protein: ENSMUSP00000140329
Gene: ENSMUSG00000026201

Domain	Start	End	E-Value	Type
S_TKc	20	203	1.1e-5	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000187103

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000189242

Predicted Effect

probably benign
Transcript: ENSMUST00000188460

SMART Domains

Protein: ENSMUSP00000139998
Gene: ENSMUSG00000026201

Domain	Start	End	E-Value	Type
S_TKc	20	172	1e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000186758

SMART Domains

Protein: ENSMUSP00000140552
Gene: ENSMUSG00000026202

Domain	Start	End	E-Value	Type
Pfam:Tubulin	1	100	1.1e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000189131

SMART Domains

Protein: ENSMUSP00000140970
Gene: ENSMUSG00000026202

Domain	Start	End	E-Value	Type
Pfam:Tubulin	1	81	3.6e-15	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000190717

SMART Domains

Protein: ENSMUSP00000141097
Gene: ENSMUSG00000026202

Domain	Start	End	E-Value	Type
Pfam:Tubulin	1	89	1.4e-18	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000186971

Predicted Effect

probably benign
Transcript: ENSMUST00000188593

SMART Domains

Protein: ENSMUSP00000140881
Gene: ENSMUSG00000026202

Domain	Start	End	E-Value	Type
Pfam:Tubulin	2	75	2e-16	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acbd3	C	T	1: 180,572,670 (GRCm39)	A310V	possibly damaging	Het
Acmsd	C	A	1: 127,685,750 (GRCm39)	S197*	probably null	Het
Adgrg4	A	T	X: 56,022,956 (GRCm39)	N2761I	probably damaging	Het
Amy1	G	A	3: 113,349,649 (GRCm39)	A507V	probably benign	Het
Apob	T	C	12: 8,063,818 (GRCm39)	F316S	possibly damaging	Het
Arhgap10	T	C	8: 78,003,781 (GRCm39)	T675A	probably benign	Het
Bbx	A	G	16: 50,022,935 (GRCm39)	I675T	probably damaging	Het
Cep126	C	A	9: 8,100,531 (GRCm39)	E668*	probably null	Het
Cnga2	A	G	X: 71,052,772 (GRCm39)	D549G	probably damaging	Het
Dnah1	T	A	14: 30,996,348 (GRCm39)	I2663F	probably damaging	Het
Fmo5	A	G	3: 97,549,122 (GRCm39)	M257V	probably benign	Het
Galntl6	T	C	8: 59,364,436 (GRCm39)	I25V	probably benign	Het
Il17ra	A	G	6: 120,449,075 (GRCm39)	N54S	probably damaging	Het
Mthfd1l	A	T	10: 3,991,826 (GRCm39)	T593S	probably benign	Het
Or10ag2	G	A	2: 87,248,412 (GRCm39)	V7I	probably benign	Het
Or1e30	G	T	11: 73,678,211 (GRCm39)	W149L	probably damaging	Het
Or5ar1	A	T	2: 85,671,725 (GRCm39)	S137T	probably damaging	Het
Or5h25	A	T	16: 58,930,325 (GRCm39)	V216D	possibly damaging	Het
Rnasel	T	A	1: 153,634,301 (GRCm39)	L578Q	probably damaging	Het
Serpinb1a	A	G	13: 33,034,352 (GRCm39)	L13S	probably damaging	Het
Slf1	G	A	13: 77,198,096 (GRCm39)	P726L	probably benign	Het
Spta1	T	C	1: 174,046,309 (GRCm39)	M1630T	probably damaging	Het
Tnxb	T	C	17: 34,911,499 (GRCm39)	F1724L	possibly damaging	Het
Vmn1r58	T	C	7: 5,413,835 (GRCm39)	I132V	probably benign	Het
Zbtb41	T	C	1: 139,374,688 (GRCm39)	I716T	probably damaging	Het

Other mutations in Stk16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01992:Stk16	APN	1	75,189,835 (GRCm39)	missense	probably benign
IGL02993:Stk16	APN	1	75,189,648 (GRCm39)	missense	probably damaging	1.00
R5342:Stk16	UTSW	1	75,189,609 (GRCm39)	missense	probably benign	0.31
R5699:Stk16	UTSW	1	75,190,248 (GRCm39)	missense	probably damaging	1.00
R7445:Stk16	UTSW	1	75,190,296 (GRCm39)	missense	probably damaging	1.00
R7737:Stk16	UTSW	1	75,187,995 (GRCm39)	missense	probably damaging	1.00
R7878:Stk16	UTSW	1	75,189,589 (GRCm39)	nonsense	probably null
R8699:Stk16	UTSW	1	75,188,682 (GRCm39)	missense	probably benign	0.12
R9456:Stk16	UTSW	1	75,187,804 (GRCm39)	critical splice donor site	probably benign

Posted On

2016-08-02