Incidental Mutation 'IGL03280:Crygf'
ID 415565
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Crygf
Ensembl Gene ENSMUSG00000025945
Gene Name crystallin, gamma F
Synonyms Len-2, DGcry-2, Cryg-2, 3110001K11Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.448) question?
Stock # IGL03280
Quality Score
Chromosome 1
Chromosomal Location 65965679-65967466 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 65967329 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 151 (Y151C)
Ref Sequence ENSEMBL: ENSMUSP00000027082 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027082] [ENSMUST00000114027]
AlphaFold Q9CXV3
Predicted Effect probably damaging
Transcript: ENSMUST00000027082
AA Change: Y151C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000027082
Gene: ENSMUSG00000025945
AA Change: Y151C

XTALbg 3 82 1.11e-43 SMART
XTALbg 89 170 2.19e-47 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000114027
SMART Domains Protein: ENSMUSP00000109661
Gene: ENSMUSG00000025945

XTALbg 3 82 1.11e-43 SMART
low complexity region 104 113 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a chemically-induced single point mutation exhibit homogeneous cataracts while heterozygotes display less severe rays and concentric circles of lens opacity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Asb4 T C 6: 5,423,416 (GRCm39) S188P probably benign Het
Bbs5 A G 2: 69,497,315 (GRCm39) probably benign Het
Cdh13 G T 8: 120,040,873 (GRCm39) G693W probably damaging Het
Cdh20 T A 1: 110,036,498 (GRCm39) Y559* probably null Het
Cemip G A 7: 83,636,538 (GRCm39) probably benign Het
Crem A G 18: 3,273,415 (GRCm39) probably benign Het
Dcp1b T C 6: 119,157,019 (GRCm39) probably benign Het
Fanca A G 8: 124,043,198 (GRCm39) probably benign Het
Fkbp15 A C 4: 62,221,504 (GRCm39) probably benign Het
Gabrp C T 11: 33,502,616 (GRCm39) R416Q probably benign Het
Iho1 T C 9: 108,282,099 (GRCm39) S530G possibly damaging Het
Impg2 T A 16: 56,088,631 (GRCm39) Y1052* probably null Het
Isg15 T C 4: 156,284,319 (GRCm39) M70V probably benign Het
Krit1 T A 5: 3,861,248 (GRCm39) probably benign Het
Lrrn3 T C 12: 41,504,146 (GRCm39) D57G probably damaging Het
Macrod1 A G 19: 7,174,937 (GRCm39) E309G possibly damaging Het
Notch1 A T 2: 26,367,886 (GRCm39) probably benign Het
Nptx1 T C 11: 119,435,555 (GRCm39) T254A probably damaging Het
Or12e9 A T 2: 87,202,467 (GRCm39) D197V probably damaging Het
Pigm A G 1: 172,204,420 (GRCm39) Y52C probably damaging Het
Pramel27 A T 4: 143,578,489 (GRCm39) T250S possibly damaging Het
Rif1 A G 2: 52,002,611 (GRCm39) T2022A probably benign Het
Rint1 T A 5: 24,022,076 (GRCm39) L646Q probably damaging Het
Rpe65 A T 3: 159,309,978 (GRCm39) I84F probably damaging Het
Scgb2b7 A T 7: 31,404,506 (GRCm39) C65S probably damaging Het
Scnn1a T C 6: 125,319,744 (GRCm39) probably benign Het
Selenop T C 15: 3,310,104 (GRCm39) probably benign Het
Siglecf T G 7: 43,005,354 (GRCm39) V438G probably benign Het
St8sia4 T A 1: 95,581,499 (GRCm39) probably benign Het
Tfeb T C 17: 48,096,862 (GRCm39) F43S probably benign Het
Tgm6 A G 2: 129,980,851 (GRCm39) Y216C probably damaging Het
Try10 T A 6: 41,331,154 (GRCm39) V10E probably benign Het
Ttn A T 2: 76,728,811 (GRCm39) C1234* probably null Het
Ugt2a3 G A 5: 87,484,439 (GRCm39) P195L probably damaging Het
Usp24 T G 4: 106,237,627 (GRCm39) I1095R probably damaging Het
Usp34 C T 11: 23,304,897 (GRCm39) H377Y probably damaging Het
Other mutations in Crygf
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0632:Crygf UTSW 1 65,967,156 (GRCm39) nonsense probably null
R1514:Crygf UTSW 1 65,967,197 (GRCm39) missense possibly damaging 0.53
R2312:Crygf UTSW 1 65,965,717 (GRCm39) start codon destroyed probably benign 0.00
R6541:Crygf UTSW 1 65,967,224 (GRCm39) missense probably damaging 0.99
R7018:Crygf UTSW 1 65,967,130 (GRCm39) missense probably benign 0.00
R8803:Crygf UTSW 1 65,967,148 (GRCm39) missense probably damaging 0.99
X0023:Crygf UTSW 1 65,965,924 (GRCm39) missense probably damaging 0.99
Posted On 2016-08-02