Incidental Mutation 'IGL03280:Crygf'
ID 415565
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Crygf
Ensembl Gene ENSMUSG00000025945
Gene Name crystallin, gamma F
Synonyms Cryg-2, Len-2, 3110001K11Rik, DGcry-2
Accession Numbers
Essential gene? Possibly essential (E-score: 0.506) question?
Stock # IGL03280
Quality Score
Chromosome 1
Chromosomal Location 65926520-65928307 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 65928170 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 151 (Y151C)
Ref Sequence ENSEMBL: ENSMUSP00000027082 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027082] [ENSMUST00000114027]
AlphaFold Q9CXV3
Predicted Effect probably damaging
Transcript: ENSMUST00000027082
AA Change: Y151C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000027082
Gene: ENSMUSG00000025945
AA Change: Y151C

XTALbg 3 82 1.11e-43 SMART
XTALbg 89 170 2.19e-47 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000114027
SMART Domains Protein: ENSMUSP00000109661
Gene: ENSMUSG00000025945

XTALbg 3 82 1.11e-43 SMART
low complexity region 104 113 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a chemically-induced single point mutation exhibit homogeneous cataracts while heterozygotes display less severe rays and concentric circles of lens opacity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Asb4 T C 6: 5,423,416 S188P probably benign Het
Bbs5 A G 2: 69,666,971 probably benign Het
Ccdc36 T C 9: 108,404,900 S530G possibly damaging Het
Cdh13 G T 8: 119,314,134 G693W probably damaging Het
Cdh7 T A 1: 110,108,768 Y559* probably null Het
Cemip G A 7: 83,987,330 probably benign Het
Crem A G 18: 3,273,415 probably benign Het
Dcp1b T C 6: 119,180,058 probably benign Het
Fanca A G 8: 123,316,459 probably benign Het
Fkbp15 A C 4: 62,303,267 probably benign Het
Gabrp C T 11: 33,552,616 R416Q probably benign Het
Gm13103 A T 4: 143,851,919 T250S possibly damaging Het
Impg2 T A 16: 56,268,268 Y1052* probably null Het
Isg15 T C 4: 156,199,862 M70V probably benign Het
Krit1 T A 5: 3,811,248 probably benign Het
Lrrn3 T C 12: 41,454,147 D57G probably damaging Het
Macrod1 A G 19: 7,197,572 E309G possibly damaging Het
Notch1 A T 2: 26,477,874 probably benign Het
Nptx1 T C 11: 119,544,729 T254A probably damaging Het
Olfr1121 A T 2: 87,372,123 D197V probably damaging Het
Pigm A G 1: 172,376,853 Y52C probably damaging Het
Rif1 A G 2: 52,112,599 T2022A probably benign Het
Rint1 T A 5: 23,817,078 L646Q probably damaging Het
Rpe65 A T 3: 159,604,341 I84F probably damaging Het
Scgb2b7 A T 7: 31,705,081 C65S probably damaging Het
Scnn1a T C 6: 125,342,781 probably benign Het
Selenop T C 15: 3,280,622 probably benign Het
Siglecf T G 7: 43,355,930 V438G probably benign Het
St8sia4 T A 1: 95,653,774 probably benign Het
Tfeb T C 17: 47,785,937 F43S probably benign Het
Tgm6 A G 2: 130,138,931 Y216C probably damaging Het
Try10 T A 6: 41,354,220 V10E probably benign Het
Ttn A T 2: 76,898,467 C1234* probably null Het
Ugt2a3 G A 5: 87,336,580 P195L probably damaging Het
Usp24 T G 4: 106,380,430 I1095R probably damaging Het
Usp34 C T 11: 23,354,897 H377Y probably damaging Het
Other mutations in Crygf
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0632:Crygf UTSW 1 65927997 nonsense probably null
R1514:Crygf UTSW 1 65928038 missense possibly damaging 0.53
R2312:Crygf UTSW 1 65926558 start codon destroyed probably benign 0.00
R6541:Crygf UTSW 1 65928065 missense probably damaging 0.99
R7018:Crygf UTSW 1 65927971 missense probably benign 0.00
R8803:Crygf UTSW 1 65927989 missense probably damaging 0.99
X0023:Crygf UTSW 1 65926765 missense probably damaging 0.99
Posted On 2016-08-02