Incidental Mutation 'IGL03301:Fnd3c2'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fnd3c2
Ensembl Gene ENSMUSG00000073012
Gene Namefibronectin type III domain containing 3C2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.034) question?
Stock #IGL03301
Quality Score
Chromosomal Location106235246-106255376 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 106252263 bp
Amino Acid Change Glutamine to Lysine at position 49 (Q49K)
Ref Sequence ENSEMBL: ENSMUSP00000088827 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091282]
Predicted Effect probably benign
Transcript: ENSMUST00000091282
AA Change: Q49K

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000088827
Gene: ENSMUSG00000073012
AA Change: Q49K

low complexity region 14 29 N/A INTRINSIC
FN3 139 223 5.07e0 SMART
FN3 237 317 3.93e-9 SMART
FN3 332 414 5.11e-8 SMART
FN3 429 513 2.21e-3 SMART
FN3 613 688 3.93e-9 SMART
FN3 702 783 2.31e-6 SMART
FN3 798 876 2.14e-1 SMART
low complexity region 896 916 N/A INTRINSIC
transmembrane domain 922 940 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts3 T C 5: 89,707,404 E418G probably damaging Het
Arl14 T C 3: 69,222,943 F141S probably damaging Het
C1s1 A T 6: 124,541,324 probably benign Het
Cilp T C 9: 65,280,217 V1198A probably benign Het
Cnbd1 A T 4: 19,055,039 I129K probably benign Het
Ctdp1 G A 18: 80,449,634 Q549* probably null Het
Cyp2ab1 T A 16: 20,313,799 I250F possibly damaging Het
Dmd G A X: 83,908,514 R1765Q probably damaging Het
Dnah1 C T 14: 31,292,692 G1739R probably damaging Het
Eml6 T C 11: 29,764,083 K1350E probably benign Het
Ephx4 C A 5: 107,426,864 T256K probably benign Het
Heatr1 G T 13: 12,434,205 G1889W probably damaging Het
Igkv19-93 A T 6: 68,736,481 W55R probably damaging Het
Jak1 T C 4: 101,175,173 Y412C probably damaging Het
Moxd1 A T 10: 24,279,484 N261I probably damaging Het
Mrgpra1 T C 7: 47,335,416 N172D probably benign Het
Papolg T C 11: 23,874,503 N293S probably benign Het
Piezo2 A G 18: 63,027,704 S2294P probably damaging Het
Ppp3cb A T 14: 20,523,984 V262D probably damaging Het
Rhox7a A G X: 37,840,011 T235A probably benign Het
Saal1 A G 7: 46,702,520 probably benign Het
Scrn1 G A 6: 54,548,337 R16* probably null Het
Slc22a2 A G 17: 12,606,039 R263G probably damaging Het
Speer3 T A 5: 13,795,433 L160H probably damaging Het
Tmcc2 T C 1: 132,360,819 M377V possibly damaging Het
Tsen2 T G 6: 115,568,771 Y341D probably damaging Het
Vmn2r13 A T 5: 109,158,089 V541D probably damaging Het
Vmn2r15 A G 5: 109,297,355 probably null Het
Zfp711 T C X: 112,633,401 Y710H probably damaging Het
Zmiz2 C T 11: 6,401,170 T566M probably damaging Het
Other mutations in Fnd3c2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00591:Fnd3c2 APN X 106235991 missense probably damaging 1.00
IGL01515:Fnd3c2 APN X 106238487 missense probably damaging 1.00
IGL02484:Fnd3c2 APN X 106245486 missense probably damaging 0.99
R0630:Fnd3c2 UTSW X 106239157 missense probably benign 0.37
R0654:Fnd3c2 UTSW X 106247154 missense possibly damaging 0.83
R1678:Fnd3c2 UTSW X 106237699 missense probably benign 0.00
Posted On2016-08-02