Incidental Mutation 'IGL03301:Arl14'
ID416220
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Arl14
Ensembl Gene ENSMUSG00000098207
Gene NameADP-ribosylation factor-like 14
Synonyms9130014L17Rik, Arf7
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.135) question?
Stock #IGL03301
Quality Score
Status
Chromosome3
Chromosomal Location69222419-69223618 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 69222943 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Serine at position 141 (F141S)
Ref Sequence ENSEMBL: ENSMUSP00000138370 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000183126]
Predicted Effect probably damaging
Transcript: ENSMUST00000183126
AA Change: F141S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000138370
Gene: ENSMUSG00000098207
AA Change: F141S

DomainStartEndE-ValueType
ARF 1 180 9.31e-56 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts3 T C 5: 89,707,404 E418G probably damaging Het
C1s1 A T 6: 124,541,324 probably benign Het
Cilp T C 9: 65,280,217 V1198A probably benign Het
Cnbd1 A T 4: 19,055,039 I129K probably benign Het
Ctdp1 G A 18: 80,449,634 Q549* probably null Het
Cyp2ab1 T A 16: 20,313,799 I250F possibly damaging Het
Dmd G A X: 83,908,514 R1765Q probably damaging Het
Dnah1 C T 14: 31,292,692 G1739R probably damaging Het
Eml6 T C 11: 29,764,083 K1350E probably benign Het
Ephx4 C A 5: 107,426,864 T256K probably benign Het
Fnd3c2 G T X: 106,252,263 Q49K probably benign Het
Heatr1 G T 13: 12,434,205 G1889W probably damaging Het
Igkv19-93 A T 6: 68,736,481 W55R probably damaging Het
Jak1 T C 4: 101,175,173 Y412C probably damaging Het
Moxd1 A T 10: 24,279,484 N261I probably damaging Het
Mrgpra1 T C 7: 47,335,416 N172D probably benign Het
Papolg T C 11: 23,874,503 N293S probably benign Het
Piezo2 A G 18: 63,027,704 S2294P probably damaging Het
Ppp3cb A T 14: 20,523,984 V262D probably damaging Het
Rhox7a A G X: 37,840,011 T235A probably benign Het
Saal1 A G 7: 46,702,520 probably benign Het
Scrn1 G A 6: 54,548,337 R16* probably null Het
Slc22a2 A G 17: 12,606,039 R263G probably damaging Het
Speer3 T A 5: 13,795,433 L160H probably damaging Het
Tmcc2 T C 1: 132,360,819 M377V possibly damaging Het
Tsen2 T G 6: 115,568,771 Y341D probably damaging Het
Vmn2r13 A T 5: 109,158,089 V541D probably damaging Het
Vmn2r15 A G 5: 109,297,355 probably null Het
Zfp711 T C X: 112,633,401 Y710H probably damaging Het
Zmiz2 C T 11: 6,401,170 T566M probably damaging Het
Other mutations in Arl14
AlleleSourceChrCoordTypePredicted EffectPPH Score
R5665:Arl14 UTSW 3 69223038 missense probably damaging 1.00
R5894:Arl14 UTSW 3 69222676 missense probably benign 0.35
R6577:Arl14 UTSW 3 69223072 missense probably benign 0.06
R6860:Arl14 UTSW 3 69222696 missense probably benign
Z1176:Arl14 UTSW 3 69222648 missense probably damaging 1.00
Posted On2016-08-02