Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03307:Trgc1'

416412

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trgc1

Ensembl Gene

ENSMUSG00000076749

Gene Name

T cell receptor gamma, constant 1

Synonyms

Cgamma1, Tcrg-C1, Gm17004

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

IGL03307

Quality Score

Status

Chromosome

Chromosomal Location

19398273-19400788 bp(+) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

A to G at 19398528 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

unknown
Transcript: ENSMUST00000103558
AA Change: H85R

SMART Domains

Protein: ENSMUSP00000100338
Gene: ENSMUSG00000076749
AA Change: H85R

Domain	Start	End	E-Value	Type
IGc1	27	98	1.35e-18	SMART
transmembrane domain	138	160	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000200495

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous null mice lack dendritic epidermal T cells. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adck1	T	C	12: 88,425,823 (GRCm39)	I417T	possibly damaging	Het
Arrdc1	A	T	2: 24,816,354 (GRCm39)	I205N	probably damaging	Het
Atp6v1a	A	G	16: 43,931,922 (GRCm39)	V122A	possibly damaging	Het
Atp8a2	A	G	14: 60,253,321 (GRCm39)		probably null	Het
Cdh18	A	G	15: 23,226,872 (GRCm39)	H111R	probably damaging	Het
Cpsf3	T	A	12: 21,346,715 (GRCm39)	I196N	possibly damaging	Het
Cyp2b9	C	T	7: 25,898,476 (GRCm39)	S277L	probably benign	Het
Grik3	T	C	4: 125,535,347 (GRCm39)	M248T	possibly damaging	Het
Gusb	T	C	5: 130,028,872 (GRCm39)	*145W	probably null	Het
Il18rap	T	C	1: 40,582,227 (GRCm39)	Y383H	probably benign	Het
Lama4	T	C	10: 38,893,379 (GRCm39)	V162A	probably benign	Het
Macc1	A	T	12: 119,410,155 (GRCm39)	M308L	probably benign	Het
Or52s1b	C	T	7: 102,822,623 (GRCm39)	V74I	probably benign	Het
Or8g27	A	T	9: 39,129,309 (GRCm39)	I219F	probably benign	Het
Postn	A	G	3: 54,282,548 (GRCm39)	D503G	probably benign	Het
Robo3	A	T	9: 37,333,860 (GRCm39)	V658D	probably damaging	Het
Scrn1	G	A	6: 54,525,322 (GRCm39)	R16*	probably null	Het
Setd1b	C	A	5: 123,286,734 (GRCm39)	D593E	unknown	Het
Slc2a13	C	T	15: 91,160,317 (GRCm39)	V546M	probably damaging	Het
Spock1	T	C	13: 57,577,160 (GRCm39)	D423G	probably null	Het
Stox2	T	C	8: 47,647,065 (GRCm39)	T132A	probably damaging	Het
Tle2	T	C	10: 81,426,074 (GRCm39)	S703P	probably damaging	Het
Ttc41	T	C	10: 86,580,304 (GRCm39)	I750T	possibly damaging	Het
Vmn2r107	A	T	17: 20,577,038 (GRCm39)	K345N	probably benign	Het
Vmn2r60	T	C	7: 41,765,971 (GRCm39)	V26A	probably benign	Het
Vmn2r98	G	A	17: 19,286,242 (GRCm39)	V247I	possibly damaging	Het
Zan	A	G	5: 137,472,287 (GRCm39)	V153A	probably damaging	Het

Other mutations in Trgc1

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL03027:Trgc1	APN	13	19,398,563 (GRCm39)	nonsense	probably null
IGL03059:Trgc1	APN	13	19,400,072 (GRCm39)	nonsense	probably null
R5687:Trgc1	UTSW	13	19,400,729 (GRCm39)	missense	unknown
R6786:Trgc1	UTSW	13	19,400,646 (GRCm39)	missense	unknown
R7840:Trgc1	UTSW	13	19,400,691 (GRCm39)	missense
R8166:Trgc1	UTSW	13	19,400,772 (GRCm39)	missense

Posted On

2016-08-02