Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03307:Cyp2b9'

416408

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2b9

Ensembl Gene

ENSMUSG00000040660

Gene Name

cytochrome P450, family 2, subfamily b, polypeptide 9

Synonyms

16\alphaoh-a, phenobarbitol inducible, type a, Cyp2b

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.098) question?

Stock #

IGL03307

Quality Score

Status

Chromosome

Chromosomal Location

26173411-26210661 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 26199051 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Leucine at position 277 (S277L)

Ref Sequence

ENSEMBL: ENSMUSP00000080846 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000082214]

AlphaFold

P12790

Predicted Effect

probably benign
Transcript: ENSMUST00000082214
AA Change: S277L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000080846
Gene: ENSMUSG00000040660
AA Change: S277L

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:p450	31	488	1.7e-146	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adck1	T	C	12: 88,459,053	I417T	possibly damaging	Het
Arrdc1	A	T	2: 24,926,342	I205N	probably damaging	Het
Atp6v1a	A	G	16: 44,111,559	V122A	possibly damaging	Het
Atp8a2	A	G	14: 60,015,872		probably null	Het
Cdh18	A	G	15: 23,226,786	H111R	probably damaging	Het
Cpsf3	T	A	12: 21,296,714	I196N	possibly damaging	Het
Grik3	T	C	4: 125,641,554	M248T	possibly damaging	Het
Gusb	T	C	5: 130,000,031	*145W	probably null	Het
Il18rap	T	C	1: 40,543,067	Y383H	probably benign	Het
Lama4	T	C	10: 39,017,383	V162A	probably benign	Het
Macc1	A	T	12: 119,446,420	M308L	probably benign	Het
Olfr591	C	T	7: 103,173,416	V74I	probably benign	Het
Olfr944	A	T	9: 39,218,013	I219F	probably benign	Het
Postn	A	G	3: 54,375,127	D503G	probably benign	Het
Robo3	A	T	9: 37,422,564	V658D	probably damaging	Het
Scrn1	G	A	6: 54,548,337	R16*	probably null	Het
Setd1b	C	A	5: 123,148,671	D593E	unknown	Het
Slc2a13	C	T	15: 91,276,114	V546M	probably damaging	Het
Spock1	T	C	13: 57,429,347	D423G	probably null	Het
Stox2	T	C	8: 47,194,030	T132A	probably damaging	Het
Tcrg-C1	A	G	13: 19,214,358		probably benign	Het
Tle2	T	C	10: 81,590,240	S703P	probably damaging	Het
Ttc41	T	C	10: 86,744,440	I750T	possibly damaging	Het
Vmn2r107	A	T	17: 20,356,776	K345N	probably benign	Het
Vmn2r60	T	C	7: 42,116,547	V26A	probably benign	Het
Vmn2r98	G	A	17: 19,065,980	V247I	possibly damaging	Het
Zan	A	G	5: 137,474,025	V153A	probably damaging	Het

Other mutations in Cyp2b9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00901:Cyp2b9	APN	7	26198505	missense	probably damaging	0.99
IGL01133:Cyp2b9	APN	7	26210235	missense	probably damaging	1.00
IGL01331:Cyp2b9	APN	7	26187715	missense	probably damaging	0.99
IGL02281:Cyp2b9	APN	7	26201104	missense	probably damaging	0.99
IGL02502:Cyp2b9	APN	7	26187814	critical splice donor site	probably null
IGL02713:Cyp2b9	APN	7	26173520	missense	probably benign	0.12
IGL03032:Cyp2b9	APN	7	26198600	splice site	probably benign
R0010:Cyp2b9	UTSW	7	26186753	splice site	probably benign
R0025:Cyp2b9	UTSW	7	26200813	missense	probably benign	0.09
R0040:Cyp2b9	UTSW	7	26173474	missense	possibly damaging	0.68
R0184:Cyp2b9	UTSW	7	26187007	nonsense	probably null
R0370:Cyp2b9	UTSW	7	26210106	missense	probably damaging	1.00
R1595:Cyp2b9	UTSW	7	26200907	missense	possibly damaging	0.72
R1751:Cyp2b9	UTSW	7	26186675	missense	probably benign	0.05
R1835:Cyp2b9	UTSW	7	26200783	missense	probably benign
R1879:Cyp2b9	UTSW	7	26198569	missense	probably damaging	0.99
R2256:Cyp2b9	UTSW	7	26173605	critical splice donor site	probably null
R2257:Cyp2b9	UTSW	7	26173605	critical splice donor site	probably null
R2418:Cyp2b9	UTSW	7	26186707	missense	probably benign	0.00
R3420:Cyp2b9	UTSW	7	26210103	missense	probably damaging	1.00
R4088:Cyp2b9	UTSW	7	26173456	missense	probably damaging	0.99
R4412:Cyp2b9	UTSW	7	26198443	missense	probably damaging	1.00
R4495:Cyp2b9	UTSW	7	26200755	missense	probably benign	0.00
R4615:Cyp2b9	UTSW	7	26201125	missense	probably damaging	1.00
R5375:Cyp2b9	UTSW	7	26187742	missense	probably damaging	1.00
R5426:Cyp2b9	UTSW	7	26187655	missense	probably benign
R5862:Cyp2b9	UTSW	7	26187807	missense	probably benign	0.01
R6237:Cyp2b9	UTSW	7	26173574	missense	probably benign	0.02
R6445:Cyp2b9	UTSW	7	26186987	missense	probably benign	0.13
R6992:Cyp2b9	UTSW	7	26201139	missense	probably benign	0.00
R7515:Cyp2b9	UTSW	7	26199171	missense	probably damaging	1.00
R7654:Cyp2b9	UTSW	7	26186942	missense	possibly damaging	0.72
R7816:Cyp2b9	UTSW	7	26201092	missense	probably benign	0.01
R7850:Cyp2b9	UTSW	7	26186686	nonsense	probably null
R8734:Cyp2b9	UTSW	7	26198610	intron	probably benign
R8790:Cyp2b9	UTSW	7	26198742	intron	probably benign
R8839:Cyp2b9	UTSW	7	26200760	missense	probably damaging	0.96
R9209:Cyp2b9	UTSW	7	26173579	missense	possibly damaging	0.52
R9723:Cyp2b9	UTSW	7	26210171	nonsense	probably null
R9787:Cyp2b9	UTSW	7	26200834	missense	probably benign	0.04
Z1177:Cyp2b9	UTSW	7	26201163	missense	probably benign	0.31

Posted On

2016-08-02