Incidental Mutation 'IGL01160:Dnajc5g'
ID53559
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dnajc5g
Ensembl Gene ENSMUSG00000053856
Gene NameDnaJ heat shock protein family (Hsp40) member C5 gamma
Synonyms4922503E23Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01160
Quality Score
Status
Chromosome5
Chromosomal Location31106285-31112526 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 31110185 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 112 (V112A)
Ref Sequence ENSEMBL: ENSMUSP00000064587 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066544] [ENSMUST00000201396] [ENSMUST00000201740] [ENSMUST00000202433] [ENSMUST00000202740] [ENSMUST00000202760]
Predicted Effect probably benign
Transcript: ENSMUST00000066544
AA Change: V112A

PolyPhen 2 Score 0.370 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000064587
Gene: ENSMUSG00000053856
AA Change: V112A

DomainStartEndE-ValueType
DnaJ 16 74 4.3e-27 SMART
low complexity region 114 132 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000201396
SMART Domains Protein: ENSMUSP00000144295
Gene: ENSMUSG00000029151

DomainStartEndE-ValueType
Pfam:Cation_efflux 27 124 1.1e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000201740
SMART Domains Protein: ENSMUSP00000144137
Gene: ENSMUSG00000053856

DomainStartEndE-ValueType
DnaJ 16 74 2.8e-29 SMART
Predicted Effect silent
Transcript: ENSMUST00000202433
SMART Domains Protein: ENSMUSP00000143997
Gene: ENSMUSG00000053856

DomainStartEndE-ValueType
SCOP:d1gh6a_ 10 41 1e-5 SMART
Blast:DnaJ 17 48 4e-8 BLAST
low complexity region 49 61 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000202740
SMART Domains Protein: ENSMUSP00000144566
Gene: ENSMUSG00000029151

DomainStartEndE-ValueType
Pfam:Cation_efflux 27 244 3e-46 PFAM
Predicted Effect silent
Transcript: ENSMUST00000202760
SMART Domains Protein: ENSMUSP00000144548
Gene: ENSMUSG00000053856

DomainStartEndE-ValueType
SCOP:d1gh6a_ 10 41 1e-5 SMART
Blast:DnaJ 17 48 4e-8 BLAST
low complexity region 49 61 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210016F16Rik A G 13: 58,381,976 V274A probably damaging Het
Atp11a A G 8: 12,844,609 T188A probably damaging Het
Bfsp2 A G 9: 103,480,168 V20A probably benign Het
Btn1a1 G A 13: 23,461,737 T154M possibly damaging Het
Ccdc117 T C 11: 5,531,532 S200G probably benign Het
Col24a1 G A 3: 145,507,713 G1358S probably damaging Het
Crlf2 T C 5: 109,557,570 T40A possibly damaging Het
Cstf2 T A X: 134,060,729 probably benign Het
Dcdc2a A G 13: 25,119,329 D281G probably benign Het
Dmd T C X: 83,924,961 L1855P probably damaging Het
Dnmt1 G A 9: 20,917,319 P828S possibly damaging Het
Dock3 A T 9: 106,906,688 S268R probably damaging Het
Dpep2 C T 8: 105,986,444 V440M possibly damaging Het
F8 A T X: 75,288,061 M741K probably damaging Het
Fermt3 C T 19: 7,003,258 probably null Het
Fosb A G 7: 19,307,114 probably null Het
Gm14085 A C 2: 122,524,796 probably null Het
Gm3238 C A 10: 77,770,883 probably benign Het
Hyal5 T A 6: 24,876,481 S118T possibly damaging Het
Igf2r T C 17: 12,704,775 D1140G possibly damaging Het
Ighmbp2 G T 19: 3,276,750 probably benign Het
Irf3 C A 7: 44,998,796 D28E possibly damaging Het
Ly6i A T 15: 74,980,032 I96N possibly damaging Het
Macrod2 T C 2: 140,825,042 probably benign Het
Olfr1222 A T 2: 89,125,728 M1K probably null Het
Olfr124 A G 17: 37,806,050 R302G probably benign Het
Olfr1309 A G 2: 111,983,933 L47P probably damaging Het
Olfr67 C T 7: 103,787,636 G214R probably damaging Het
Otof A T 5: 30,381,535 M1128K probably benign Het
Parp9 A T 16: 35,947,998 I183F probably damaging Het
Pbsn T C X: 77,842,571 N147S probably benign Het
Pcf11 A G 7: 92,661,686 S365P possibly damaging Het
Pcnx4 T G 12: 72,579,377 V1119G probably damaging Het
Rsf1 C T 7: 97,685,584 T1308M probably damaging Het
Sidt2 A G 9: 45,942,726 L647P probably damaging Het
Slc7a8 A G 14: 54,735,124 V280A probably benign Het
Spg20 T A 3: 55,121,756 F323I probably damaging Het
Supt16 A T 14: 52,183,132 D70E probably benign Het
Tmc4 T C 7: 3,675,518 Y38C possibly damaging Het
Tmco5b G T 2: 113,287,798 probably benign Het
Trav10 G A 14: 53,505,782 probably benign Het
Vmn2r28 A T 7: 5,486,478 M454K probably damaging Het
Vmn2r85 T C 10: 130,418,821 T665A probably benign Het
Yipf7 T C 5: 69,519,317 I160V probably benign Het
Zc3h18 T C 8: 122,408,250 probably benign Het
Zfp429 G A 13: 67,391,013 S91L probably damaging Het
Other mutations in Dnajc5g
AlleleSourceChrCoordTypePredicted EffectPPH Score
R5046:Dnajc5g UTSW 5 31109692 missense probably benign 0.22
R7395:Dnajc5g UTSW 5 31111665 missense possibly damaging 0.61
R8073:Dnajc5g UTSW 5 31111685 missense probably benign 0.00
Posted On2013-06-28