Incidental Mutation 'R8227:Rps16'
ID 637023
Institutional Source Beutler Lab
Gene Symbol Rps16
Ensembl Gene ENSMUSG00000037563
Gene Name ribosomal protein S16
Synonyms
MMRRC Submission 067644-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.931) question?
Stock # R8227 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 28050114-28052123 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 28051926 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 101 (D101E)
Ref Sequence ENSEMBL: ENSMUSP00000103940 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082134]
AlphaFold P14131
Predicted Effect probably benign
Transcript: ENSMUST00000082134
AA Change: D101E

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000103940
Gene: ENSMUSG00000037563
AA Change: D101E

DomainStartEndE-ValueType
Pfam:Ribosomal_S9 14 146 1.2e-38 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.3%
  • 20x: 97.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S9P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp7 C A 7: 28,316,073 (GRCm39) S171I probably damaging Het
Arhgap24 A G 5: 103,023,647 (GRCm39) E227G probably benign Het
Atp13a4 A G 16: 29,222,663 (GRCm39) V1087A Het
Csnk1g2 G A 10: 80,474,463 (GRCm39) probably null Het
Dlc1 A G 8: 37,039,825 (GRCm39) L994S probably damaging Het
Dusp13b A G 14: 21,792,869 (GRCm39) S19P probably benign Het
Foxr1 T C 9: 44,347,304 (GRCm39) S78G probably benign Het
Gm1968 T A 16: 29,777,380 (GRCm39) K93N noncoding transcript Het
Gm4781 G A 10: 100,232,424 (GRCm39) P171S noncoding transcript Het
Gm7276 T A 18: 77,273,158 (GRCm39) Q192L unknown Het
Greb1l T A 18: 10,515,371 (GRCm39) L721H probably damaging Het
Grm3 T C 5: 9,620,242 (GRCm39) D334G possibly damaging Het
Lama3 C T 18: 12,540,608 (GRCm39) A304V probably benign Het
Lamc1 G A 1: 153,099,500 (GRCm39) S1491L probably benign Het
Lepr T C 4: 101,628,559 (GRCm39) S555P probably damaging Het
Mup14 C T 4: 61,258,494 (GRCm39) E97K probably benign Het
Pdss2 A T 10: 43,221,577 (GRCm39) H163L probably damaging Het
Rpusd4 T C 9: 35,179,831 (GRCm39) V108A probably benign Het
Slc7a14 T C 3: 31,263,361 (GRCm39) K727R probably benign Het
Snx6 A T 12: 54,798,756 (GRCm39) F351I possibly damaging Het
Son CATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCTCCATGGACTCCCAGATGTTAGCAAC CATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCTCCATGGACTCCCAGATGTTAGCAAC 16: 91,453,579 (GRCm39) probably benign Het
Togaram2 T A 17: 72,021,237 (GRCm39) Y675* probably null Het
Other mutations in Rps16
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0126:Rps16 UTSW 7 28,050,508 (GRCm39) missense probably damaging 0.99
R8296:Rps16 UTSW 7 28,052,008 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- ACATGTGGCCCAAATTTATGG -3'
(R):5'- AAAGGTAAACCCCGATCCTTG -3'

Sequencing Primer
(F):5'- TGGTAAGTCTCAGGATCTAAGCC -3'
(R):5'- GGTAAACCCCGATCCTTGAGATG -3'
Posted On 2020-07-13