Incidental Mutation 'IGL01311:Klrc3'
ID 73687
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Klrc3
Ensembl Gene ENSMUSG00000033027
Gene Name killer cell lectin-like receptor subfamily C, member 3
Synonyms NKG2E
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # IGL01311
Quality Score
Status
Chromosome 6
Chromosomal Location 129616027-129620300 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 129618375 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 136 (D136G)
Ref Sequence ENSEMBL: ENSMUSP00000129830 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071149] [ENSMUST00000170148] [ENSMUST00000203189]
AlphaFold Q9QXN7
Predicted Effect probably damaging
Transcript: ENSMUST00000071149
AA Change: D144G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000071147
Gene: ENSMUSG00000033027
AA Change: D144G

DomainStartEndE-ValueType
transmembrane domain 66 88 N/A INTRINSIC
CLECT 105 216 1.96e-18 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000170148
AA Change: D136G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000129830
Gene: ENSMUSG00000033027
AA Change: D136G

DomainStartEndE-ValueType
transmembrane domain 66 88 N/A INTRINSIC
CLECT 97 208 1.96e-18 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000203189
SMART Domains Protein: ENSMUSP00000144993
Gene: ENSMUSG00000033027

DomainStartEndE-ValueType
transmembrane domain 66 88 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arap1 A T 7: 101,037,343 (GRCm39) K457* probably null Het
Arhgef10 C A 8: 15,041,054 (GRCm39) probably null Het
Becn1 C T 11: 101,182,342 (GRCm39) G281S probably damaging Het
Borcs8 A G 8: 70,617,818 (GRCm39) S59G probably damaging Het
Brd10 C T 19: 29,731,420 (GRCm39) V531I probably benign Het
Capn5 C A 7: 97,811,130 (GRCm39) R53L probably damaging Het
Cdk5 C T 5: 24,624,593 (GRCm39) probably null Het
Cnksr1 A G 4: 133,957,777 (GRCm39) L434P probably damaging Het
Col22a1 C T 15: 71,845,486 (GRCm39) probably benign Het
Fn1 T C 1: 71,667,299 (GRCm39) D811G probably damaging Het
Haus3 G A 5: 34,324,988 (GRCm39) Q224* probably null Het
Jakmip2 A G 18: 43,690,389 (GRCm39) probably benign Het
Jam3 T G 9: 27,010,019 (GRCm39) T296P probably damaging Het
Kcnrg T C 14: 61,849,274 (GRCm39) L245P probably damaging Het
Kif1b A G 4: 149,305,059 (GRCm39) L909P probably damaging Het
Lrrc37 T A 11: 103,425,502 (GRCm39) R1450S unknown Het
Ltf T C 9: 110,860,080 (GRCm39) probably benign Het
Meig1 A T 2: 3,410,245 (GRCm39) V85D possibly damaging Het
Mrgprb2 T A 7: 48,201,746 (GRCm39) E326D probably benign Het
Nlrp2 T A 7: 5,322,238 (GRCm39) D65V possibly damaging Het
Or4c100 T C 2: 88,356,104 (GRCm39) F59S possibly damaging Het
Or52h7 T C 7: 104,214,036 (GRCm39) Y203H probably damaging Het
Padi2 G A 4: 140,644,948 (GRCm39) V61I probably benign Het
Pkd1l1 T C 11: 8,851,174 (GRCm39) S753G possibly damaging Het
Ppp4r3b T C 11: 29,144,591 (GRCm39) S314P probably benign Het
Serpina3i T C 12: 104,233,946 (GRCm39) S305P probably damaging Het
Slc16a4 G T 3: 107,199,821 (GRCm39) V23F possibly damaging Het
Slc25a34 G A 4: 141,348,747 (GRCm39) T239I possibly damaging Het
Srebf2 T C 15: 82,076,404 (GRCm39) probably benign Het
Tasor2 A G 13: 3,625,885 (GRCm39) V1355A possibly damaging Het
Tcf12 A T 9: 71,765,938 (GRCm39) probably benign Het
Tnpo3 T C 6: 29,586,077 (GRCm39) E171G possibly damaging Het
Ubr4 A G 4: 139,206,356 (GRCm39) H4864R possibly damaging Het
Vmn2r108 A T 17: 20,682,939 (GRCm39) L755* probably null Het
Zfp292 C T 4: 34,807,961 (GRCm39) M1699I probably benign Het
Zmynd8 T C 2: 165,647,129 (GRCm39) D880G probably damaging Het
Other mutations in Klrc3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00754:Klrc3 APN 6 129,618,389 (GRCm39) missense probably damaging 1.00
IGL02634:Klrc3 APN 6 129,620,171 (GRCm39) missense probably damaging 0.99
IGL02806:Klrc3 APN 6 129,616,065 (GRCm39) missense possibly damaging 0.52
R1568:Klrc3 UTSW 6 129,616,510 (GRCm39) missense probably benign 0.01
R2132:Klrc3 UTSW 6 129,618,501 (GRCm39) missense probably benign
R2517:Klrc3 UTSW 6 129,616,520 (GRCm39) missense probably damaging 1.00
R3833:Klrc3 UTSW 6 129,620,181 (GRCm39) missense probably damaging 0.99
R4355:Klrc3 UTSW 6 129,616,125 (GRCm39) missense probably benign 0.09
R5085:Klrc3 UTSW 6 129,616,538 (GRCm39) missense probably damaging 0.99
R5247:Klrc3 UTSW 6 129,618,425 (GRCm39) missense probably damaging 1.00
R5426:Klrc3 UTSW 6 129,618,513 (GRCm39) missense probably benign 0.04
R7557:Klrc3 UTSW 6 129,616,107 (GRCm39) missense probably damaging 0.99
R9168:Klrc3 UTSW 6 129,616,142 (GRCm39) missense probably damaging 1.00
Posted On 2013-10-07