Incidental Mutation 'IGL01532:Gpalpp1'
ID89787
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpalpp1
Ensembl Gene ENSMUSG00000022008
Gene NameGPALPP motifs containing 1
Synonyms1200011I18Rik
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL01532
Quality Score
Status
Chromosome14
Chromosomal Location76086236-76110760 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 76102502 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Glutamic Acid at position 124 (K124E)
Ref Sequence ENSEMBL: ENSMUSP00000022585 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022585]
Predicted Effect probably benign
Transcript: ENSMUST00000022585
AA Change: K124E

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000022585
Gene: ENSMUSG00000022008
AA Change: K124E

DomainStartEndE-ValueType
low complexity region 41 67 N/A INTRINSIC
low complexity region 105 117 N/A INTRINSIC
Pfam:DUF3752 202 338 8.9e-25 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts17 C A 7: 66,908,601 N264K probably damaging Het
Adgrl3 C T 5: 81,694,569 T260I probably damaging Het
Ambra1 G T 2: 91,885,632 K769N probably damaging Het
Arel1 A G 12: 84,934,162 V357A possibly damaging Het
Atp11b T A 3: 35,849,502 C76* probably null Het
AW112010 C A 19: 11,048,069 noncoding transcript Het
Bfar A T 16: 13,687,387 probably benign Het
Ccdc70 T G 8: 21,973,283 L30V probably damaging Het
Chrm5 C T 2: 112,479,232 R513Q probably benign Het
Crem G A 18: 3,276,732 T7I probably benign Het
Cyp4f39 C T 17: 32,470,954 probably benign Het
Dlg5 T C 14: 24,158,592 T849A probably benign Het
Dock8 G T 19: 25,169,441 G1428V probably damaging Het
Eomes T C 9: 118,482,249 I380T probably damaging Het
Fam13a T C 6: 58,940,295 D532G probably damaging Het
Fopnl A G 16: 14,304,511 S130P probably benign Het
Gm10061 G T 16: 89,151,302 *55L probably null Het
Gm27438 T G 2: 87,252,925 probably benign Het
Hgs T A 11: 120,477,509 probably null Het
Hpn T A 7: 31,103,513 M121L possibly damaging Het
Il1r1 T C 1: 40,294,928 probably null Het
Jag2 A T 12: 112,914,363 C583S probably damaging Het
Katnal2 T C 18: 77,012,000 H146R probably benign Het
Ldah T C 12: 8,220,596 probably benign Het
Lvrn T A 18: 46,900,484 Y921N probably damaging Het
Muc5b A G 7: 141,870,006 Y4572C possibly damaging Het
Myo16 A G 8: 10,400,551 S518G probably benign Het
Ncf1 T C 5: 134,226,593 N148S probably benign Het
Nes T G 3: 87,978,347 D1260E possibly damaging Het
Nup210 C A 6: 91,085,999 probably benign Het
Olfr548-ps1 T C 7: 102,542,656 L240P probably damaging Het
Rnf31 C A 14: 55,602,623 Q968K probably damaging Het
Ros1 A G 10: 52,090,938 probably benign Het
Ryk T C 9: 102,897,266 Y400H probably benign Het
Slc4a5 T A 6: 83,273,040 probably null Het
Sptssb A G 3: 69,820,869 probably benign Het
Sstr5 T C 17: 25,491,331 D308G probably damaging Het
Taf2 A G 15: 55,049,486 W493R possibly damaging Het
Vmn2r28 T A 7: 5,486,464 I459L probably benign Het
Vti1b A C 12: 79,165,138 L1W probably null Het
Wdr1 T C 5: 38,535,187 Y125C probably damaging Het
Other mutations in Gpalpp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2019:Gpalpp1 UTSW 14 76110691 splice site probably null
R2327:Gpalpp1 UTSW 14 76098591 missense probably benign 0.08
R3196:Gpalpp1 UTSW 14 76098623 splice site probably null
R6394:Gpalpp1 UTSW 14 76107412 missense possibly damaging 0.53
R7153:Gpalpp1 UTSW 14 76095011 missense probably damaging 1.00
Posted On2013-12-03