Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00807:Ccr1l1'

9474

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ccr1l1

Ensembl Gene

ENSMUSG00000064039

Gene Name

chemokine (C-C motif) receptor 1-like 1

Synonyms

MIP-1 alphaRL1, Cmkbr1l1

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00807

Quality Score

Status

Chromosome

Chromosomal Location

123977243-123978408 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 123977469 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Arginine at position 314 (W314R)

Ref Sequence

ENSEMBL: ENSMUSP00000071353 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071404]

AlphaFold

P51676

Predicted Effect

probably benign
Transcript: ENSMUST00000071404
AA Change: W314R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000071353
Gene: ENSMUSG00000064039
AA Change: W314R

Domain	Start	End	E-Value	Type
Pfam:7tm_1	52	302	6.6e-42	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a targeted null mutation do not exhibit any significant abnormalities compared to controls. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 19 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	A	T	11: 9,378,285	T3453S	probably benign	Het
Ahnak	T	A	19: 9,008,522	V2390E	possibly damaging	Het
Aldh8a1	A	T	10: 21,395,430	I352F	probably damaging	Het
Ccnt2	T	C	1: 127,797,891		probably benign	Het
Cdc42bpa	A	G	1: 180,141,453	I1218V	possibly damaging	Het
Dlc1	G	A	8: 36,572,848	T1386I	probably benign	Het
Frs2	A	C	10: 117,074,886		probably benign	Het
Gm4951	C	T	18: 60,245,411	S6F	probably damaging	Het
Gria1	T	C	11: 57,012,040	Y3H	probably benign	Het
Ints2	T	C	11: 86,233,135	N609S	probably damaging	Het
Lyst	T	A	13: 13,650,423	M1541K	possibly damaging	Het
Mmachc	A	T	4: 116,705,921	V79E	probably damaging	Het
Nfe2l2	T	C	2: 75,679,413	D21G	probably damaging	Het
Pde2a	G	A	7: 101,504,412	V436M	probably damaging	Het
Rhot1	C	T	11: 80,226,102	H101Y	probably benign	Het
Sh2d4a	T	C	8: 68,329,366		probably null	Het
Taar2	A	G	10: 23,940,675	M38V	probably benign	Het
Tek	A	T	4: 94,798,719	N158I	probably damaging	Het
Znrd1as	G	T	17: 36,964,921	A132S	probably damaging	Het

Other mutations in Ccr1l1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02161:Ccr1l1	APN	9	123977963	missense	possibly damaging	0.87
IGL02293:Ccr1l1	APN	9	123977936	missense	possibly damaging	0.87
IGL03179:Ccr1l1	APN	9	123977750	missense	probably damaging	1.00
IGL03294:Ccr1l1	APN	9	123978407	start codon destroyed	probably null	0.56
R1672:Ccr1l1	UTSW	9	123977507	missense	probably damaging	1.00
R2165:Ccr1l1	UTSW	9	123977654	missense	probably damaging	1.00
R2170:Ccr1l1	UTSW	9	123978135	missense	possibly damaging	0.79
R2886:Ccr1l1	UTSW	9	123977516	missense	probably damaging	1.00
R4834:Ccr1l1	UTSW	9	123977705	missense	probably damaging	1.00
R5598:Ccr1l1	UTSW	9	123977993	missense	probably benign
R6458:Ccr1l1	UTSW	9	123978166	missense	probably damaging	1.00
R8525:Ccr1l1	UTSW	9	123977552	missense	possibly damaging	0.61
X0019:Ccr1l1	UTSW	9	123977789	missense	probably damaging	1.00
Z1088:Ccr1l1	UTSW	9	123977850	missense	probably benign

Posted On

2012-12-06