Mutagenetix > Incidental Mutation

Incidental Mutation 'R1205:Vmn1r32'

100410

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r32

Ensembl Gene

ENSMUSG00000062905

Gene Name

vomeronasal 1 receptor 32

Synonyms

V1rc15

MMRRC Submission

039275-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

R1205 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

66529167-66536692 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 66530539 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 79 (T79I)

Ref Sequence

ENSEMBL: ENSMUSP00000153723 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079584] [ENSMUST00000227014]

AlphaFold

Q8R2D9

Predicted Effect

probably benign
Transcript: ENSMUST00000079584
AA Change: T79I

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000078536
Gene: ENSMUSG00000062905
AA Change: T79I

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	9.7e-56	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000227014
AA Change: T79I

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

Coding Region Coverage

1x: 99.0%
3x: 98.1%
10x: 95.6%
20x: 90.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrg6	T	A	10: 14,310,083 (GRCm39)	N774I	probably damaging	Het
Bpifc	T	A	10: 85,817,168 (GRCm39)	D230V	probably damaging	Het
Chrna2	C	T	14: 66,380,812 (GRCm39)	A27V	probably benign	Het
Duox1	C	T	2: 122,158,406 (GRCm39)	Q630*	probably null	Het
Dzip3	C	T	16: 48,772,044 (GRCm39)	G542R	probably damaging	Het
Epha3	ATGAACTGCT	AT	16: 63,418,611 (GRCm39)		probably null	Het
Fnip1	G	T	11: 54,393,132 (GRCm39)	V523L	possibly damaging	Het
Hc	T	A	2: 34,893,536 (GRCm39)	D1225V	possibly damaging	Het
Hnrnpu	C	T	1: 178,159,734 (GRCm39)		probably benign	Het
Ift172	C	T	5: 31,443,136 (GRCm39)	V125I	probably benign	Het
Kcnip2	T	A	19: 45,783,422 (GRCm39)	Q93L	probably null	Het
Kif27	A	T	13: 58,492,019 (GRCm39)	H373Q	probably benign	Het
Kl	T	C	5: 150,904,153 (GRCm39)	S302P	probably damaging	Het
Lyst	G	A	13: 13,854,787 (GRCm39)	V2386I	probably benign	Het
Map4k4	G	A	1: 40,043,004 (GRCm39)	A128T	probably damaging	Het
Marchf6	A	C	15: 31,469,819 (GRCm39)	M717R	probably benign	Het
Morc2b	A	G	17: 33,354,908 (GRCm39)	Y955H	probably damaging	Het
Myo7b	A	G	18: 32,127,395 (GRCm39)	S636P	probably damaging	Het
Neb	T	A	2: 52,112,996 (GRCm39)	D4266V	probably damaging	Het
Nynrin	G	A	14: 56,091,646 (GRCm39)		probably benign	Het
Or1j18	G	A	2: 36,624,767 (GRCm39)	V145I	probably benign	Het
Or4c107	A	T	2: 88,788,932 (GRCm39)	I41L	probably benign	Het
Or5b104	T	C	19: 13,072,899 (GRCm39)	I38V	probably benign	Het
Pcdh9	A	G	14: 94,123,501 (GRCm39)	S890P	probably benign	Het
Pcnx1	G	T	12: 82,003,017 (GRCm39)	D1052Y	probably damaging	Het
Pibf1	G	A	14: 99,338,639 (GRCm39)	E52K	probably damaging	Het
Siglec1	T	G	2: 130,922,384 (GRCm39)	S564R	possibly damaging	Het
Sin3a	T	A	9: 57,026,459 (GRCm39)	V1125E	probably damaging	Het
Slco4c1	G	T	1: 96,795,613 (GRCm39)	D148E	probably damaging	Het
Spag6l	A	T	16: 16,605,171 (GRCm39)	L127Q	probably damaging	Het
Syne4	C	A	7: 30,014,761 (GRCm39)	T68N	probably damaging	Het
Tas2r134	A	G	2: 51,517,998 (GRCm39)	Y159C	probably benign	Het
Tasor	A	T	14: 27,183,275 (GRCm39)	D578V	probably damaging	Het
Thoc2l	T	C	5: 104,668,079 (GRCm39)	L867S	probably benign	Het
Tmem132a	C	A	19: 10,836,448 (GRCm39)	R694L	probably benign	Het
Ttc28	C	T	5: 111,433,635 (GRCm39)	P2192L	probably benign	Het
Ttc34	T	G	4: 154,946,671 (GRCm39)	V857G	probably benign	Het
Ugt1a7c	A	T	1: 88,023,678 (GRCm39)	H279L	probably benign	Het
Vps13a	A	T	19: 16,617,905 (GRCm39)	V2960D	probably damaging	Het
Wee2	G	T	6: 40,420,875 (GRCm39)		probably benign	Het

Other mutations in Vmn1r32

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01449:Vmn1r32	APN	6	66,529,916 (GRCm39)	missense	probably benign
IGL02399:Vmn1r32	APN	6	66,529,913 (GRCm39)	missense	probably benign	0.18
IGL02964:Vmn1r32	APN	6	66,529,922 (GRCm39)	missense	probably benign	0.37
IGL03161:Vmn1r32	APN	6	66,530,204 (GRCm39)	missense	possibly damaging	0.65
IGL03244:Vmn1r32	APN	6	66,530,489 (GRCm39)	missense	probably damaging	1.00
IGL03248:Vmn1r32	APN	6	66,529,897 (GRCm39)	missense	possibly damaging	0.82
R0668:Vmn1r32	UTSW	6	66,530,644 (GRCm39)	missense	possibly damaging	0.90
R0732:Vmn1r32	UTSW	6	66,530,690 (GRCm39)	missense	probably benign	0.01
R1638:Vmn1r32	UTSW	6	66,529,939 (GRCm39)	missense	possibly damaging	0.53
R1732:Vmn1r32	UTSW	6	66,530,285 (GRCm39)	missense	probably benign	0.19
R2049:Vmn1r32	UTSW	6	66,530,545 (GRCm39)	missense	probably damaging	1.00
R2127:Vmn1r32	UTSW	6	66,530,533 (GRCm39)	missense	probably benign	0.09
R3773:Vmn1r32	UTSW	6	66,530,351 (GRCm39)	missense	probably benign	0.01
R3834:Vmn1r32	UTSW	6	66,530,647 (GRCm39)	missense	probably benign	0.02
R3980:Vmn1r32	UTSW	6	66,530,698 (GRCm39)	missense	probably damaging	0.98
R4737:Vmn1r32	UTSW	6	66,530,629 (GRCm39)	missense	probably damaging	1.00
R5569:Vmn1r32	UTSW	6	66,530,156 (GRCm39)	missense	probably damaging	0.98
R6382:Vmn1r32	UTSW	6	66,530,345 (GRCm39)	missense	probably benign	0.07
R6894:Vmn1r32	UTSW	6	66,530,345 (GRCm39)	missense	possibly damaging	0.94
R7394:Vmn1r32	UTSW	6	66,530,173 (GRCm39)	missense	probably benign	0.06
R7980:Vmn1r32	UTSW	6	66,530,305 (GRCm39)	nonsense	probably null
R8833:Vmn1r32	UTSW	6	66,530,623 (GRCm39)	missense	possibly damaging	0.53
R8867:Vmn1r32	UTSW	6	66,530,651 (GRCm39)	missense	probably damaging	0.98
R8975:Vmn1r32	UTSW	6	66,530,189 (GRCm39)	missense	probably benign	0.03
R9131:Vmn1r32	UTSW	6	66,530,020 (GRCm39)	missense	probably benign	0.30
R9135:Vmn1r32	UTSW	6	66,530,120 (GRCm39)	nonsense	probably null
R9429:Vmn1r32	UTSW	6	66,530,237 (GRCm39)	missense	probably benign	0.03

Predicted Primers

PCR Primer
(F):5'- TCCGGTTACTGCTGAATGACAAATTGA -3'
(R):5'- ACTGGATTTCTACCTATGAGGCTCAGG -3'

Sequencing Primer
(F):5'- CTGCTGAATGACAAATTGAAAGACC -3'
(R):5'- CAAGTTGGACTTGGAACCCTG -3'

Posted On

2014-01-15