Incidental Mutation 'IGL01663:Prmt2'
ID |
103251 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Prmt2
|
Ensembl Gene |
ENSMUSG00000020230 |
Gene Name |
protein arginine N-methyltransferase 2 |
Synonyms |
Hrmt1l1 |
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
IGL01663
|
Quality Score |
|
Status
|
|
Chromosome |
10 |
Chromosomal Location |
76043060-76073699 bp(-) (GRCm39) |
Type of Mutation |
splice site (5 bp from exon) |
DNA Base Change (assembly) |
C to T
at 76053143 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000097167
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000020452]
[ENSMUST00000020452]
[ENSMUST00000020452]
[ENSMUST00000099571]
[ENSMUST00000099571]
[ENSMUST00000099571]
[ENSMUST00000099572]
[ENSMUST00000099572]
[ENSMUST00000099572]
[ENSMUST00000128099]
[ENSMUST00000137857]
[ENSMUST00000217726]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably null
Transcript: ENSMUST00000020452
|
SMART Domains |
Protein: ENSMUSP00000020452 Gene: ENSMUSG00000020230
Domain | Start | End | E-Value | Type |
low complexity region
|
30 |
43 |
N/A |
INTRINSIC |
SH3
|
45 |
100 |
4.22e-15 |
SMART |
Pfam:PrmA
|
122 |
253 |
2.5e-8 |
PFAM |
Pfam:PRMT5
|
123 |
427 |
2.4e-13 |
PFAM |
Pfam:Met_10
|
127 |
244 |
5.1e-8 |
PFAM |
Pfam:MTS
|
134 |
223 |
5.7e-11 |
PFAM |
Pfam:Methyltransf_31
|
147 |
294 |
1.5e-8 |
PFAM |
Pfam:Methyltransf_26
|
150 |
224 |
1.2e-9 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000020452
|
SMART Domains |
Protein: ENSMUSP00000020452 Gene: ENSMUSG00000020230
Domain | Start | End | E-Value | Type |
low complexity region
|
30 |
43 |
N/A |
INTRINSIC |
SH3
|
45 |
100 |
4.22e-15 |
SMART |
Pfam:PrmA
|
122 |
253 |
2.5e-8 |
PFAM |
Pfam:PRMT5
|
123 |
427 |
2.4e-13 |
PFAM |
Pfam:Met_10
|
127 |
244 |
5.1e-8 |
PFAM |
Pfam:MTS
|
134 |
223 |
5.7e-11 |
PFAM |
Pfam:Methyltransf_31
|
147 |
294 |
1.5e-8 |
PFAM |
Pfam:Methyltransf_26
|
150 |
224 |
1.2e-9 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000020452
|
SMART Domains |
Protein: ENSMUSP00000020452 Gene: ENSMUSG00000020230
Domain | Start | End | E-Value | Type |
low complexity region
|
30 |
43 |
N/A |
INTRINSIC |
SH3
|
45 |
100 |
4.22e-15 |
SMART |
Pfam:PrmA
|
122 |
253 |
2.5e-8 |
PFAM |
Pfam:PRMT5
|
123 |
427 |
2.4e-13 |
PFAM |
Pfam:Met_10
|
127 |
244 |
5.1e-8 |
PFAM |
Pfam:MTS
|
134 |
223 |
5.7e-11 |
PFAM |
Pfam:Methyltransf_31
|
147 |
294 |
1.5e-8 |
PFAM |
Pfam:Methyltransf_26
|
150 |
224 |
1.2e-9 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000099571
|
SMART Domains |
Protein: ENSMUSP00000097166 Gene: ENSMUSG00000020230
Domain | Start | End | E-Value | Type |
low complexity region
|
30 |
43 |
N/A |
INTRINSIC |
SH3
|
45 |
100 |
4.22e-15 |
SMART |
Pfam:PrmA
|
122 |
253 |
2.5e-8 |
PFAM |
Pfam:PRMT5
|
123 |
427 |
2.4e-13 |
PFAM |
Pfam:Met_10
|
127 |
244 |
5.1e-8 |
PFAM |
Pfam:MTS
|
134 |
223 |
5.7e-11 |
PFAM |
Pfam:Methyltransf_31
|
147 |
294 |
1.5e-8 |
PFAM |
Pfam:Methyltransf_26
|
150 |
224 |
1.2e-9 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000099571
|
SMART Domains |
Protein: ENSMUSP00000097166 Gene: ENSMUSG00000020230
Domain | Start | End | E-Value | Type |
low complexity region
|
30 |
43 |
N/A |
INTRINSIC |
SH3
|
45 |
100 |
4.22e-15 |
SMART |
Pfam:PrmA
|
122 |
253 |
2.5e-8 |
PFAM |
Pfam:PRMT5
|
123 |
427 |
2.4e-13 |
PFAM |
Pfam:Met_10
|
127 |
244 |
5.1e-8 |
PFAM |
Pfam:MTS
|
134 |
223 |
5.7e-11 |
PFAM |
Pfam:Methyltransf_31
|
147 |
294 |
1.5e-8 |
PFAM |
Pfam:Methyltransf_26
|
150 |
224 |
1.2e-9 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000099571
|
SMART Domains |
Protein: ENSMUSP00000097166 Gene: ENSMUSG00000020230
Domain | Start | End | E-Value | Type |
low complexity region
|
30 |
43 |
N/A |
INTRINSIC |
SH3
|
45 |
100 |
4.22e-15 |
SMART |
Pfam:PrmA
|
122 |
253 |
2.5e-8 |
PFAM |
Pfam:PRMT5
|
123 |
427 |
2.4e-13 |
PFAM |
Pfam:Met_10
|
127 |
244 |
5.1e-8 |
PFAM |
Pfam:MTS
|
134 |
223 |
5.7e-11 |
PFAM |
Pfam:Methyltransf_31
|
147 |
294 |
1.5e-8 |
PFAM |
Pfam:Methyltransf_26
|
150 |
224 |
1.2e-9 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000099572
|
SMART Domains |
Protein: ENSMUSP00000097167 Gene: ENSMUSG00000020230
Domain | Start | End | E-Value | Type |
low complexity region
|
30 |
43 |
N/A |
INTRINSIC |
SH3
|
45 |
100 |
4.22e-15 |
SMART |
Pfam:PrmA
|
124 |
253 |
3.1e-8 |
PFAM |
Pfam:PRMT5
|
124 |
451 |
1.2e-11 |
PFAM |
Pfam:MTS
|
137 |
223 |
3.3e-10 |
PFAM |
Pfam:Methyltransf_31
|
147 |
294 |
1.7e-8 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000099572
|
SMART Domains |
Protein: ENSMUSP00000097167 Gene: ENSMUSG00000020230
Domain | Start | End | E-Value | Type |
low complexity region
|
30 |
43 |
N/A |
INTRINSIC |
SH3
|
45 |
100 |
4.22e-15 |
SMART |
Pfam:PrmA
|
124 |
253 |
3.1e-8 |
PFAM |
Pfam:PRMT5
|
124 |
451 |
1.2e-11 |
PFAM |
Pfam:MTS
|
137 |
223 |
3.3e-10 |
PFAM |
Pfam:Methyltransf_31
|
147 |
294 |
1.7e-8 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000099572
|
SMART Domains |
Protein: ENSMUSP00000097167 Gene: ENSMUSG00000020230
Domain | Start | End | E-Value | Type |
low complexity region
|
30 |
43 |
N/A |
INTRINSIC |
SH3
|
45 |
100 |
4.22e-15 |
SMART |
Pfam:PrmA
|
124 |
253 |
3.1e-8 |
PFAM |
Pfam:PRMT5
|
124 |
451 |
1.2e-11 |
PFAM |
Pfam:MTS
|
137 |
223 |
3.3e-10 |
PFAM |
Pfam:Methyltransf_31
|
147 |
294 |
1.7e-8 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000128099
|
SMART Domains |
Protein: ENSMUSP00000137707 Gene: ENSMUSG00000020230
Domain | Start | End | E-Value | Type |
low complexity region
|
30 |
43 |
N/A |
INTRINSIC |
SH3
|
45 |
100 |
4.22e-15 |
SMART |
Pfam:PrmA
|
120 |
253 |
1.3e-9 |
PFAM |
Pfam:Met_10
|
122 |
235 |
3.8e-8 |
PFAM |
Pfam:TehB
|
122 |
235 |
6.9e-8 |
PFAM |
Pfam:MTS
|
133 |
223 |
2e-11 |
PFAM |
Pfam:Methyltransf_31
|
147 |
243 |
9.3e-9 |
PFAM |
Pfam:Methyltransf_26
|
150 |
224 |
4.6e-10 |
PFAM |
Pfam:Methyltransf_11
|
154 |
238 |
3.2e-6 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000137857
|
SMART Domains |
Protein: ENSMUSP00000137725 Gene: ENSMUSG00000020230
Domain | Start | End | E-Value | Type |
low complexity region
|
30 |
43 |
N/A |
INTRINSIC |
SH3
|
45 |
100 |
4.22e-15 |
SMART |
Pfam:PrmA
|
120 |
253 |
1.5e-9 |
PFAM |
Pfam:Met_10
|
129 |
235 |
4.2e-7 |
PFAM |
Pfam:MTS
|
137 |
223 |
1.1e-10 |
PFAM |
Pfam:Methyltransf_31
|
147 |
243 |
9.2e-9 |
PFAM |
Pfam:Methyltransf_11
|
154 |
237 |
1.7e-6 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000217726
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000220116
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele display a hyperplastic response to vascular injury while mutant mouse embryonic fibroblasts show an earlier S phase entry following release of serum starvation. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 33 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Acaca |
A |
G |
11: 84,168,628 (GRCm39) |
I1085V |
possibly damaging |
Het |
Adamts16 |
T |
C |
13: 70,941,260 (GRCm39) |
T376A |
probably benign |
Het |
Aifm3 |
T |
A |
16: 17,320,650 (GRCm39) |
|
probably null |
Het |
Ankrd16 |
A |
G |
2: 11,783,473 (GRCm39) |
E25G |
probably damaging |
Het |
Ano6 |
T |
A |
15: 95,865,495 (GRCm39) |
|
probably null |
Het |
Cdh18 |
T |
C |
15: 23,446,077 (GRCm39) |
I509T |
possibly damaging |
Het |
Cdon |
A |
G |
9: 35,394,510 (GRCm39) |
T919A |
possibly damaging |
Het |
Clca3a2 |
G |
A |
3: 144,522,916 (GRCm39) |
P148L |
probably damaging |
Het |
Dnph1 |
G |
T |
17: 46,809,408 (GRCm39) |
R74L |
probably benign |
Het |
Epha6 |
C |
T |
16: 59,596,007 (GRCm39) |
A895T |
probably damaging |
Het |
Exoc3l4 |
T |
A |
12: 111,395,845 (GRCm39) |
|
probably benign |
Het |
Fbll1 |
A |
G |
11: 35,688,648 (GRCm39) |
I205T |
probably damaging |
Het |
Frem2 |
T |
A |
3: 53,424,434 (GRCm39) |
H3001L |
probably damaging |
Het |
Galk2 |
A |
G |
2: 125,825,099 (GRCm39) |
N432D |
probably benign |
Het |
Gm7535 |
A |
C |
17: 18,131,619 (GRCm39) |
|
probably benign |
Het |
Il10 |
A |
G |
1: 130,949,151 (GRCm39) |
E104G |
probably benign |
Het |
Il1a |
T |
C |
2: 129,146,637 (GRCm39) |
K152R |
probably benign |
Het |
Kdm1b |
T |
A |
13: 47,227,213 (GRCm39) |
N568K |
probably damaging |
Het |
Kmt2c |
A |
C |
5: 25,515,668 (GRCm39) |
L2725R |
probably damaging |
Het |
Krba1 |
G |
T |
6: 48,388,688 (GRCm39) |
L527F |
probably damaging |
Het |
Lrp2 |
A |
G |
2: 69,259,050 (GRCm39) |
S4547P |
probably benign |
Het |
Nin |
G |
T |
12: 70,090,439 (GRCm39) |
A992E |
possibly damaging |
Het |
Or11g7 |
G |
A |
14: 50,690,607 (GRCm39) |
V33M |
probably benign |
Het |
Or5p81 |
T |
A |
7: 108,267,098 (GRCm39) |
H158Q |
probably benign |
Het |
Pcdhb1 |
A |
G |
18: 37,400,186 (GRCm39) |
I712M |
possibly damaging |
Het |
Rbm20 |
T |
G |
19: 53,829,426 (GRCm39) |
V608G |
probably damaging |
Het |
Smarcc2 |
C |
T |
10: 128,324,846 (GRCm39) |
|
probably benign |
Het |
Speer3 |
A |
T |
5: 13,843,236 (GRCm39) |
R48* |
probably null |
Het |
Tlr1 |
A |
T |
5: 65,082,416 (GRCm39) |
N720K |
possibly damaging |
Het |
Tnfrsf21 |
A |
T |
17: 43,398,702 (GRCm39) |
M603L |
probably benign |
Het |
Ttc3 |
T |
A |
16: 94,210,590 (GRCm39) |
|
probably null |
Het |
Usp4 |
C |
A |
9: 108,243,079 (GRCm39) |
A249E |
possibly damaging |
Het |
Wdr20 |
T |
A |
12: 110,759,948 (GRCm39) |
V278E |
probably damaging |
Het |
|
Other mutations in Prmt2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01642:Prmt2
|
APN |
10 |
76,058,327 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02015:Prmt2
|
APN |
10 |
76,062,089 (GRCm39) |
nonsense |
probably null |
|
IGL03094:Prmt2
|
APN |
10 |
76,046,224 (GRCm39) |
splice site |
probably benign |
|
R0352:Prmt2
|
UTSW |
10 |
76,044,337 (GRCm39) |
missense |
possibly damaging |
0.89 |
R0617:Prmt2
|
UTSW |
10 |
76,044,517 (GRCm39) |
intron |
probably benign |
|
R0831:Prmt2
|
UTSW |
10 |
76,043,641 (GRCm39) |
unclassified |
probably benign |
|
R0885:Prmt2
|
UTSW |
10 |
76,058,399 (GRCm39) |
missense |
probably damaging |
1.00 |
R1882:Prmt2
|
UTSW |
10 |
76,058,302 (GRCm39) |
missense |
probably benign |
0.00 |
R2022:Prmt2
|
UTSW |
10 |
76,061,292 (GRCm39) |
nonsense |
probably null |
|
R2312:Prmt2
|
UTSW |
10 |
76,062,089 (GRCm39) |
nonsense |
probably null |
|
R2401:Prmt2
|
UTSW |
10 |
76,061,249 (GRCm39) |
nonsense |
probably null |
|
R2408:Prmt2
|
UTSW |
10 |
76,044,301 (GRCm39) |
missense |
probably damaging |
0.98 |
R3753:Prmt2
|
UTSW |
10 |
76,061,137 (GRCm39) |
missense |
probably benign |
0.01 |
R4707:Prmt2
|
UTSW |
10 |
76,062,055 (GRCm39) |
missense |
probably damaging |
0.96 |
R4785:Prmt2
|
UTSW |
10 |
76,062,055 (GRCm39) |
missense |
probably damaging |
0.96 |
R4937:Prmt2
|
UTSW |
10 |
76,056,842 (GRCm39) |
missense |
probably damaging |
1.00 |
R5072:Prmt2
|
UTSW |
10 |
76,058,390 (GRCm39) |
missense |
probably damaging |
1.00 |
R5073:Prmt2
|
UTSW |
10 |
76,058,390 (GRCm39) |
missense |
probably damaging |
1.00 |
R5074:Prmt2
|
UTSW |
10 |
76,058,390 (GRCm39) |
missense |
probably damaging |
1.00 |
R5851:Prmt2
|
UTSW |
10 |
76,072,574 (GRCm39) |
missense |
possibly damaging |
0.61 |
R6084:Prmt2
|
UTSW |
10 |
76,046,278 (GRCm39) |
missense |
probably benign |
0.23 |
R6120:Prmt2
|
UTSW |
10 |
76,045,280 (GRCm39) |
missense |
possibly damaging |
0.51 |
R6239:Prmt2
|
UTSW |
10 |
76,058,425 (GRCm39) |
nonsense |
probably null |
|
R6317:Prmt2
|
UTSW |
10 |
76,058,351 (GRCm39) |
missense |
probably benign |
0.15 |
R6659:Prmt2
|
UTSW |
10 |
76,053,208 (GRCm39) |
missense |
possibly damaging |
0.85 |
R7174:Prmt2
|
UTSW |
10 |
76,061,173 (GRCm39) |
missense |
probably benign |
0.00 |
R7421:Prmt2
|
UTSW |
10 |
76,056,912 (GRCm39) |
missense |
probably benign |
0.00 |
R7485:Prmt2
|
UTSW |
10 |
76,056,838 (GRCm39) |
nonsense |
probably null |
|
R8326:Prmt2
|
UTSW |
10 |
76,053,247 (GRCm39) |
missense |
probably benign |
0.00 |
R9490:Prmt2
|
UTSW |
10 |
76,053,227 (GRCm39) |
missense |
probably damaging |
0.98 |
R9620:Prmt2
|
UTSW |
10 |
76,061,213 (GRCm39) |
missense |
probably damaging |
1.00 |
R9694:Prmt2
|
UTSW |
10 |
76,061,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Posted On |
2014-01-21 |