Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01794:Suco'

155300

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Suco

Ensembl Gene

ENSMUSG00000040297

Gene Name

SUN domain containing ossification factor

Synonyms

AI848100, osteopotentia, Opt

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.557) question?

Stock #

IGL01794

Quality Score

Status

Chromosome

Chromosomal Location

161643683-161704251 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 161655294 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 1066 (M1066T)

Ref Sequence

ENSEMBL: ENSMUSP00000044815 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000048377]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000048377
AA Change: M1066T

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000044815
Gene: ENSMUSG00000040297
AA Change: M1066T

Domain	Start	End	E-Value	Type
signal peptide	1	29	N/A	INTRINSIC
low complexity region	32	41	N/A	INTRINSIC
low complexity region	117	145	N/A	INTRINSIC
low complexity region	208	224	N/A	INTRINSIC
low complexity region	272	284	N/A	INTRINSIC
Pfam:Sad1_UNC	325	455	9e-43	PFAM
low complexity region	665	683	N/A	INTRINSIC
low complexity region	745	758	N/A	INTRINSIC
coiled coil region	933	1009	N/A	INTRINSIC
low complexity region	1014	1030	N/A	INTRINSIC
low complexity region	1105	1119	N/A	INTRINSIC
low complexity region	1163	1176	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000191841

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000192422

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000192573

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a mutation in this gene display background strain-dependent neonatal and postnatal lethality, and impaired osteoblast differentiation resulting in impaired bone formation, brittle bones, and impaired fracture repair. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 21 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930590J08Rik	C	T	6: 91,895,093 (GRCm39)	R263*	probably null	Het
Appl2	A	G	10: 83,450,158 (GRCm39)	V238A	probably benign	Het
Bcl2l11	T	A	2: 127,970,568 (GRCm39)	S6T	probably damaging	Het
Bptf	A	G	11: 106,944,047 (GRCm39)		probably null	Het
Catsper3	T	C	13: 55,946,719 (GRCm39)	S139P	possibly damaging	Het
Cdh3	A	G	8: 107,263,758 (GRCm39)	N192S	possibly damaging	Het
Dsc1	A	T	18: 20,243,240 (GRCm39)	I71N	probably damaging	Het
Fbxw2	A	G	2: 34,701,131 (GRCm39)		probably benign	Het
Gad1	G	T	2: 70,427,512 (GRCm39)	V473L	probably benign	Het
Golm2	T	A	2: 121,742,407 (GRCm39)	N206K	probably benign	Het
Gtpbp1	C	T	15: 79,600,447 (GRCm39)	T460I	probably damaging	Het
Krt16	G	A	11: 100,138,731 (GRCm39)	T185I	probably benign	Het
Mapk1ip1	C	T	7: 138,438,426 (GRCm39)	M1I	probably null	Het
Nt5e	A	T	9: 88,249,351 (GRCm39)	L428F	probably damaging	Het
Or5p54	A	G	7: 107,554,502 (GRCm39)	Y218C	probably damaging	Het
Pah	G	T	10: 87,414,784 (GRCm39)	V379F	possibly damaging	Het
Scn7a	T	C	2: 66,505,853 (GRCm39)	T1679A	probably benign	Het
Sdccag8	T	A	1: 176,672,873 (GRCm39)	H293Q	possibly damaging	Het
Spmip4	T	C	6: 50,554,826 (GRCm39)	I268M	probably damaging	Het
Trim9	A	G	12: 70,328,654 (GRCm39)	Y369H	probably damaging	Het
Usp34	G	A	11: 23,386,020 (GRCm39)	R2149H	probably damaging	Het

Other mutations in Suco

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01432:Suco	APN	1	161,661,689 (GRCm39)	missense	probably damaging	1.00
IGL01688:Suco	APN	1	161,691,480 (GRCm39)	splice site	probably null
IGL01891:Suco	APN	1	161,666,371 (GRCm39)	missense	probably damaging	1.00
IGL02028:Suco	APN	1	161,684,428 (GRCm39)	missense	possibly damaging	0.95
IGL02102:Suco	APN	1	161,655,274 (GRCm39)	missense	probably damaging	1.00
IGL02351:Suco	APN	1	161,646,195 (GRCm39)	missense	probably benign	0.35
IGL02358:Suco	APN	1	161,646,195 (GRCm39)	missense	probably benign	0.35
IGL02392:Suco	APN	1	161,662,136 (GRCm39)	missense	probably benign	0.11
IGL02638:Suco	APN	1	161,655,256 (GRCm39)	missense	probably damaging	1.00
IGL02650:Suco	APN	1	161,676,322 (GRCm39)	splice site	probably benign
IGL03106:Suco	APN	1	161,662,049 (GRCm39)	missense	possibly damaging	0.91
IGL03189:Suco	APN	1	161,684,906 (GRCm39)	unclassified	probably benign
IGL03328:Suco	APN	1	161,647,990 (GRCm39)	missense	probably damaging	0.99
girth	UTSW	1	161,655,809 (GRCm39)	missense	possibly damaging	0.86
pleasingly	UTSW	1	161,661,977 (GRCm39)	missense	possibly damaging	0.65
3-1:Suco	UTSW	1	161,649,600 (GRCm39)	intron	probably benign
H8562:Suco	UTSW	1	161,680,420 (GRCm39)	missense	probably damaging	1.00
H8786:Suco	UTSW	1	161,680,420 (GRCm39)	missense	probably damaging	1.00
R0023:Suco	UTSW	1	161,673,154 (GRCm39)	splice site	probably null
R0023:Suco	UTSW	1	161,673,154 (GRCm39)	splice site	probably null
R0179:Suco	UTSW	1	161,703,874 (GRCm39)	splice site	probably benign
R0299:Suco	UTSW	1	161,681,379 (GRCm39)	missense	probably benign
R0418:Suco	UTSW	1	161,662,419 (GRCm39)	missense	probably benign	0.11
R0481:Suco	UTSW	1	161,689,882 (GRCm39)	unclassified	probably benign
R0610:Suco	UTSW	1	161,691,601 (GRCm39)	splice site	probably benign
R0610:Suco	UTSW	1	161,687,072 (GRCm39)	missense	probably benign
R0634:Suco	UTSW	1	161,666,373 (GRCm39)	missense	possibly damaging	0.77
R0645:Suco	UTSW	1	161,661,683 (GRCm39)	missense	probably damaging	1.00
R1276:Suco	UTSW	1	161,685,025 (GRCm39)	missense	probably benign	0.10
R1720:Suco	UTSW	1	161,661,623 (GRCm39)	missense	probably damaging	1.00
R1739:Suco	UTSW	1	161,655,224 (GRCm39)	critical splice donor site	probably null
R1763:Suco	UTSW	1	161,662,518 (GRCm39)	missense	possibly damaging	0.80
R1835:Suco	UTSW	1	161,687,069 (GRCm39)	nonsense	probably null
R1988:Suco	UTSW	1	161,646,380 (GRCm39)	critical splice acceptor site	probably null
R2939:Suco	UTSW	1	161,676,220 (GRCm39)	missense	probably damaging	1.00
R3773:Suco	UTSW	1	161,671,565 (GRCm39)	splice site	probably null
R3882:Suco	UTSW	1	161,662,313 (GRCm39)	missense	probably benign	0.33
R4193:Suco	UTSW	1	161,691,528 (GRCm39)	missense	probably benign	0.32
R4367:Suco	UTSW	1	161,674,799 (GRCm39)	missense	probably damaging	1.00
R4397:Suco	UTSW	1	161,672,421 (GRCm39)	missense	probably damaging	1.00
R4846:Suco	UTSW	1	161,661,977 (GRCm39)	missense	possibly damaging	0.65
R4851:Suco	UTSW	1	161,661,761 (GRCm39)	missense	probably damaging	1.00
R5224:Suco	UTSW	1	161,662,274 (GRCm39)	missense	probably benign	0.06
R5329:Suco	UTSW	1	161,660,999 (GRCm39)	missense	probably damaging	0.99
R6133:Suco	UTSW	1	161,662,752 (GRCm39)	nonsense	probably null
R6632:Suco	UTSW	1	161,655,809 (GRCm39)	missense	possibly damaging	0.86
R6643:Suco	UTSW	1	161,687,001 (GRCm39)	missense	possibly damaging	0.71
R7378:Suco	UTSW	1	161,689,780 (GRCm39)	missense	possibly damaging	0.76
R7405:Suco	UTSW	1	161,655,783 (GRCm39)	missense	possibly damaging	0.65
R7509:Suco	UTSW	1	161,672,903 (GRCm39)	missense	probably damaging	1.00
R7838:Suco	UTSW	1	161,656,890 (GRCm39)	missense	probably benign	0.07
R7867:Suco	UTSW	1	161,665,365 (GRCm39)	missense	possibly damaging	0.77
R7895:Suco	UTSW	1	161,672,937 (GRCm39)	splice site	probably null
R8440:Suco	UTSW	1	161,679,907 (GRCm39)	missense	probably damaging	1.00
R8453:Suco	UTSW	1	161,650,586 (GRCm39)	intron	probably benign
R8781:Suco	UTSW	1	161,645,951 (GRCm39)	missense	probably damaging	1.00
R8798:Suco	UTSW	1	161,648,004 (GRCm39)	missense	probably damaging	1.00
R9292:Suco	UTSW	1	161,671,574 (GRCm39)	missense	probably damaging	1.00
R9310:Suco	UTSW	1	161,684,427 (GRCm39)	missense	probably damaging	1.00
R9380:Suco	UTSW	1	161,646,074 (GRCm39)	missense	possibly damaging	0.61
R9411:Suco	UTSW	1	161,666,356 (GRCm39)	missense	probably damaging	0.99
R9542:Suco	UTSW	1	161,661,668 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-02-04