Incidental Mutation 'IGL01879:Vmn2r110'
| ID |
178986 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r110
|
| Ensembl Gene |
ENSMUSG00000091259 |
| Gene Name |
vomeronasal 2, receptor 110 |
| Synonyms |
EG224582 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.211)
|
| Stock # |
IGL01879
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
20794091-20816521 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 20794122 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Arginine
at position 849
(H849R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129347
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000095633]
[ENSMUST00000169559]
|
| AlphaFold |
E9PWD5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000095633
|
| SMART Domains |
Protein: ENSMUSP00000093293
Gene: ENSMUSG00000071273
| Domain | Start | End | E-Value | Type |
|---|
|
RRM
|
17 |
84 |
5.29e-5 |
SMART |
|
low complexity region
|
101 |
113 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
130 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
175 |
N/A |
INTRINSIC |
|
low complexity region
|
179 |
199 |
N/A |
INTRINSIC |
|
RRM
|
207 |
274 |
1.55e-11 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000169559
AA Change: H849R
PolyPhen 2
Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000129347
Gene: ENSMUSG00000091259
AA Change: H849R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
467 |
3.1e-33 |
PFAM |
|
Pfam:NCD3G
|
510 |
563 |
5.2e-22 |
PFAM |
|
Pfam:7tm_3
|
594 |
831 |
4.2e-51 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Cgn |
G |
A |
3: 94,681,674 (GRCm39) |
R474* |
probably null |
Het |
| Chmp4b |
T |
C |
2: 154,534,601 (GRCm39) |
|
probably benign |
Het |
| Chst15 |
A |
G |
7: 131,871,994 (GRCm39) |
Y96H |
possibly damaging |
Het |
| Clstn3 |
A |
G |
6: 124,415,769 (GRCm39) |
S638P |
probably damaging |
Het |
| Colq |
C |
T |
14: 31,265,952 (GRCm39) |
G187E |
probably damaging |
Het |
| Cyp2b23 |
A |
G |
7: 26,372,279 (GRCm39) |
Y389H |
probably benign |
Het |
| Cyp3a13 |
T |
C |
5: 137,917,265 (GRCm39) |
Q54R |
probably benign |
Het |
| Dscc1 |
T |
C |
15: 54,950,212 (GRCm39) |
I178V |
probably benign |
Het |
| Fbxo4 |
G |
A |
15: 4,005,436 (GRCm39) |
T148M |
probably damaging |
Het |
| Gm10717 |
A |
T |
9: 3,026,287 (GRCm39) |
Y195F |
probably damaging |
Het |
| Gm10718 |
A |
T |
9: 3,025,118 (GRCm39) |
Y194F |
probably benign |
Het |
| Gm21738 |
G |
A |
14: 19,416,979 (GRCm38) |
S144L |
probably benign |
Het |
| Gpr162 |
A |
G |
6: 124,838,204 (GRCm39) |
S149P |
probably damaging |
Het |
| Grid1 |
T |
A |
14: 35,172,327 (GRCm39) |
I611N |
possibly damaging |
Het |
| Mgat5 |
T |
C |
1: 127,325,287 (GRCm39) |
F385L |
probably damaging |
Het |
| Npepps |
T |
C |
11: 97,149,166 (GRCm39) |
T17A |
possibly damaging |
Het |
| Or4c125 |
T |
C |
2: 89,170,366 (GRCm39) |
I93M |
probably benign |
Het |
| Or4n4b |
A |
G |
14: 50,535,969 (GRCm39) |
S266P |
probably benign |
Het |
| Or5p60 |
A |
T |
7: 107,724,371 (GRCm39) |
I33N |
possibly damaging |
Het |
| Or7g29 |
A |
T |
9: 19,286,703 (GRCm39) |
L158* |
probably null |
Het |
| Parg |
T |
C |
14: 31,993,579 (GRCm39) |
|
probably benign |
Het |
| Rad51ap2 |
A |
G |
12: 11,508,139 (GRCm39) |
D687G |
probably benign |
Het |
| Sh3bp1 |
T |
G |
15: 78,792,192 (GRCm39) |
S450A |
probably damaging |
Het |
| Skap2 |
T |
C |
6: 51,973,014 (GRCm39) |
D90G |
possibly damaging |
Het |
| Smc5 |
C |
T |
19: 23,205,548 (GRCm39) |
R796H |
probably damaging |
Het |
| Tdrd12 |
A |
C |
7: 35,221,348 (GRCm39) |
I146S |
probably damaging |
Het |
| Tinf2 |
T |
C |
14: 55,918,363 (GRCm39) |
|
probably benign |
Het |
| Trio |
G |
A |
15: 27,741,119 (GRCm39) |
T2702I |
probably benign |
Het |
| Vmn1r88 |
T |
A |
7: 12,912,229 (GRCm39) |
M195K |
probably benign |
Het |
| Vmn2r129 |
C |
T |
4: 156,690,549 (GRCm39) |
|
noncoding transcript |
Het |
| Vmn2r4 |
C |
T |
3: 64,298,431 (GRCm39) |
G566R |
probably damaging |
Het |
| Wdpcp |
A |
G |
11: 21,661,630 (GRCm39) |
T301A |
probably damaging |
Het |
|
| Other mutations in Vmn2r110 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01774:Vmn2r110
|
APN |
17 |
20,803,889 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01824:Vmn2r110
|
APN |
17 |
20,794,929 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL02168:Vmn2r110
|
APN |
17 |
20,804,062 (GRCm39) |
splice site |
probably benign |
|
|
IGL02178:Vmn2r110
|
APN |
17 |
20,804,706 (GRCm39) |
splice site |
probably null |
|
|
IGL02322:Vmn2r110
|
APN |
17 |
20,794,197 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02323:Vmn2r110
|
APN |
17 |
20,816,399 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02415:Vmn2r110
|
APN |
17 |
20,804,033 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02491:Vmn2r110
|
APN |
17 |
20,816,400 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02876:Vmn2r110
|
APN |
17 |
20,794,558 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03141:Vmn2r110
|
APN |
17 |
20,803,976 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL03270:Vmn2r110
|
APN |
17 |
20,803,778 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03286:Vmn2r110
|
APN |
17 |
20,804,468 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03379:Vmn2r110
|
APN |
17 |
20,803,906 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4243001:Vmn2r110
|
UTSW |
17 |
20,802,379 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0040:Vmn2r110
|
UTSW |
17 |
20,816,346 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0195:Vmn2r110
|
UTSW |
17 |
20,794,317 (GRCm39) |
missense |
probably benign |
0.31 |
|
R0716:Vmn2r110
|
UTSW |
17 |
20,794,165 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1199:Vmn2r110
|
UTSW |
17 |
20,803,525 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1767:Vmn2r110
|
UTSW |
17 |
20,800,840 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2212:Vmn2r110
|
UTSW |
17 |
20,794,209 (GRCm39) |
splice site |
probably null |
|
|
R3056:Vmn2r110
|
UTSW |
17 |
20,803,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4093:Vmn2r110
|
UTSW |
17 |
20,803,642 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4418:Vmn2r110
|
UTSW |
17 |
20,803,951 (GRCm39) |
nonsense |
probably null |
|
|
R4598:Vmn2r110
|
UTSW |
17 |
20,804,029 (GRCm39) |
nonsense |
probably null |
|
|
R4754:Vmn2r110
|
UTSW |
17 |
20,816,458 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5283:Vmn2r110
|
UTSW |
17 |
20,800,899 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5421:Vmn2r110
|
UTSW |
17 |
20,803,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5672:Vmn2r110
|
UTSW |
17 |
20,816,494 (GRCm39) |
missense |
probably benign |
|
|
R5865:Vmn2r110
|
UTSW |
17 |
20,804,557 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6642:Vmn2r110
|
UTSW |
17 |
20,803,779 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6799:Vmn2r110
|
UTSW |
17 |
20,803,798 (GRCm39) |
missense |
probably benign |
|
|
R7167:Vmn2r110
|
UTSW |
17 |
20,794,441 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7291:Vmn2r110
|
UTSW |
17 |
20,794,471 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7320:Vmn2r110
|
UTSW |
17 |
20,816,316 (GRCm39) |
missense |
probably benign |
|
|
R7519:Vmn2r110
|
UTSW |
17 |
20,804,524 (GRCm39) |
missense |
probably benign |
|
|
R8089:Vmn2r110
|
UTSW |
17 |
20,803,807 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8234:Vmn2r110
|
UTSW |
17 |
20,804,691 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8272:Vmn2r110
|
UTSW |
17 |
20,816,490 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8307:Vmn2r110
|
UTSW |
17 |
20,803,319 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8506:Vmn2r110
|
UTSW |
17 |
20,804,627 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8516:Vmn2r110
|
UTSW |
17 |
20,794,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8555:Vmn2r110
|
UTSW |
17 |
20,804,618 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8691:Vmn2r110
|
UTSW |
17 |
20,803,404 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8859:Vmn2r110
|
UTSW |
17 |
20,794,560 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8935:Vmn2r110
|
UTSW |
17 |
20,803,957 (GRCm39) |
missense |
probably benign |
0.40 |
|
R8986:Vmn2r110
|
UTSW |
17 |
20,803,823 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9012:Vmn2r110
|
UTSW |
17 |
20,803,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9101:Vmn2r110
|
UTSW |
17 |
20,794,471 (GRCm39) |
missense |
|
|
|
R9744:Vmn2r110
|
UTSW |
17 |
20,794,848 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9803:Vmn2r110
|
UTSW |
17 |
20,803,730 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1088:Vmn2r110
|
UTSW |
17 |
20,803,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2014-05-07 |
Incidental Mutation