Mutagenetix > Incidental Mutation

Incidental Mutation 'R4598:Vmn2r110'

345384

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r110

Ensembl Gene

ENSMUSG00000091259

Gene Name

vomeronasal 2, receptor 110

Synonyms

EG224582

MMRRC Submission

041814-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.211) question?

Stock #

R4598 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

20794091-20816521 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 20804029 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Stop codon at position 182 (L182*)

Ref Sequence

ENSEMBL: ENSMUSP00000129347 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169559]

AlphaFold

E9PWD5

Predicted Effect

probably null
Transcript: ENSMUST00000169559
AA Change: L182*

SMART Domains

Protein: ENSMUSP00000129347
Gene: ENSMUSG00000091259
AA Change: L182*

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	3.1e-33	PFAM
Pfam:NCD3G	510	563	5.2e-22	PFAM
Pfam:7tm_3	594	831	4.2e-51	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 95.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 67 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A830018L16Rik	G	A	1: 11,818,188 (GRCm39)		probably null	Het
Abca14	T	C	7: 119,854,626 (GRCm39)	V930A	probably benign	Het
Abcb7	A	C	X: 103,366,988 (GRCm39)	D135E	probably benign	Het
Ace	T	A	11: 105,872,585 (GRCm39)		probably null	Het
Acnat1	T	C	4: 49,450,781 (GRCm39)	D110G	probably benign	Het
Ak9	C	T	10: 41,259,907 (GRCm39)	P862S	probably damaging	Het
Atp1a3	A	G	7: 24,678,766 (GRCm39)	S972P	probably damaging	Het
Bmf	C	A	2: 118,379,609 (GRCm39)	A56S	probably benign	Het
C6	T	C	15: 4,792,852 (GRCm39)	L319P	possibly damaging	Het
Cab39	A	G	1: 85,776,050 (GRCm39)	Y249C	probably damaging	Het
Cdc14b	T	C	13: 64,395,088 (GRCm39)	T69A	probably benign	Het
Cep162	A	G	9: 87,085,848 (GRCm39)	Y1159H	possibly damaging	Het
Chrna7	A	G	7: 62,753,538 (GRCm39)	M327T	probably damaging	Het
Clca3a2	A	T	3: 144,511,444 (GRCm39)	N41K	probably damaging	Het
Clock	T	C	5: 76,383,657 (GRCm39)	M499V	probably benign	Het
Col5a3	A	G	9: 20,685,855 (GRCm39)		probably null	Het
Coq6	T	C	12: 84,408,913 (GRCm39)	V30A	probably benign	Het
Cyp3a57	A	G	5: 145,327,227 (GRCm39)	I473V	probably benign	Het
D430041D05Rik	A	T	2: 104,038,528 (GRCm39)	V1547D	probably damaging	Het
Dhx9	TCC	TC	1: 153,342,797 (GRCm39)		probably null	Het
Dock2	T	A	11: 34,189,536 (GRCm39)	Y1545F	probably damaging	Het
Eif4e3	T	A	6: 99,617,671 (GRCm39)	I67L	probably benign	Het
Epor	A	G	9: 21,873,155 (GRCm39)	S86P	probably benign	Het
Esp31	T	A	17: 38,952,012 (GRCm39)		probably null	Het
Esrp2	A	G	8: 106,859,343 (GRCm39)	M498T	probably damaging	Het
F5	T	C	1: 164,032,366 (GRCm39)	I1771T	probably benign	Het
Fancd2	C	A	6: 113,562,438 (GRCm39)	H1259Q	probably benign	Het
Gale	C	A	4: 135,695,148 (GRCm39)	S341*	probably null	Het
Ints12	T	A	3: 132,804,214 (GRCm39)	I67N	probably benign	Het
Kat2b	A	G	17: 53,977,826 (GRCm39)	Y791C	probably benign	Het
Kazn	A	G	4: 141,937,403 (GRCm39)	V108A	possibly damaging	Het
Kcnma1	T	C	14: 23,853,228 (GRCm39)	T109A	probably damaging	Het
Med13	T	C	11: 86,169,392 (GRCm39)	T1955A	probably damaging	Het
Megf10	G	A	18: 57,322,675 (GRCm39)		probably null	Het
Megf10	A	T	18: 57,420,884 (GRCm39)	S841C	probably damaging	Het
Mep1a	A	G	17: 43,802,469 (GRCm39)		probably null	Het
Mrap2	A	T	9: 87,064,842 (GRCm39)	E194D	probably damaging	Het
Msh2	A	G	17: 88,016,006 (GRCm39)	K546R	probably damaging	Het
Ndc80	T	C	17: 71,828,063 (GRCm39)	D88G	probably damaging	Het
Nrip1	A	G	16: 76,089,968 (GRCm39)	F530L	probably damaging	Het
Or2y10	T	C	11: 49,455,545 (GRCm39)	S266P	probably damaging	Het
Or52e7	A	C	7: 104,685,280 (GRCm39)	I292L	probably benign	Het
Or6c216	T	C	10: 129,678,864 (GRCm39)	T16A	possibly damaging	Het
Or9i16	A	T	19: 13,865,381 (GRCm39)	H64Q	probably damaging	Het
Oxtr	C	T	6: 112,466,713 (GRCm39)	G16R	probably benign	Het
Pdgfrb	A	T	18: 61,201,829 (GRCm39)	K464N	probably benign	Het
Pja2	A	T	17: 64,620,025 (GRCm39)	M1K	probably null	Het
Pkhd1	A	T	1: 20,573,280 (GRCm39)	N1875K	probably damaging	Het
Pogz	T	C	3: 94,787,491 (GRCm39)	S1360P	possibly damaging	Het
Proc	A	T	18: 32,256,512 (GRCm39)	L385Q	probably damaging	Het
Ptprm	A	G	17: 67,402,492 (GRCm39)	I132T	probably benign	Het
Rpgr	A	G	X: 10,062,255 (GRCm39)	S343P	probably benign	Het
Rsu1	T	C	2: 13,174,815 (GRCm39)	Y225C	probably damaging	Het
Scyl1	A	G	19: 5,820,481 (GRCm39)	S118P	probably damaging	Het
Sec61a1	T	C	6: 88,483,131 (GRCm39)	N414D	probably benign	Het
Secisbp2l	C	T	2: 125,582,657 (GRCm39)	G933D	possibly damaging	Het
Sema7a	A	G	9: 57,860,834 (GRCm39)	D65G	probably benign	Het
Slc25a45	A	G	19: 5,934,464 (GRCm39)	Y144C	probably damaging	Het
Slc26a6	A	G	9: 108,733,579 (GRCm39)	Y103C	probably damaging	Het
Stat3	C	T	11: 100,794,500 (GRCm39)	D270N	probably damaging	Het
Taar8b	T	C	10: 23,967,736 (GRCm39)	S153G	probably benign	Het
Top1	A	G	2: 160,562,885 (GRCm39)	E697G	possibly damaging	Het
Trappc11	G	A	8: 47,966,801 (GRCm39)	T470I	probably damaging	Het
Ttc7b	G	A	12: 100,466,376 (GRCm39)	R79C	probably damaging	Het
Usp29	A	G	7: 6,965,479 (GRCm39)	T441A	probably benign	Het
Zgrf1	T	C	3: 127,394,679 (GRCm39)	I1345T	probably benign	Het
Zscan25	G	T	5: 145,227,815 (GRCm39)	R493L	probably benign	Het

Other mutations in Vmn2r110

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01774:Vmn2r110	APN	17	20,803,889 (GRCm39)	missense	probably benign	0.01
IGL01824:Vmn2r110	APN	17	20,794,929 (GRCm39)	missense	probably benign	0.44
IGL01879:Vmn2r110	APN	17	20,794,122 (GRCm39)	missense	probably benign	0.01
IGL02168:Vmn2r110	APN	17	20,804,062 (GRCm39)	splice site	probably benign
IGL02178:Vmn2r110	APN	17	20,804,706 (GRCm39)	splice site	probably null
IGL02322:Vmn2r110	APN	17	20,794,197 (GRCm39)	missense	probably damaging	1.00
IGL02323:Vmn2r110	APN	17	20,816,399 (GRCm39)	missense	probably damaging	0.98
IGL02415:Vmn2r110	APN	17	20,804,033 (GRCm39)	missense	probably benign	0.03
IGL02491:Vmn2r110	APN	17	20,816,400 (GRCm39)	missense	probably damaging	0.99
IGL02876:Vmn2r110	APN	17	20,794,558 (GRCm39)	missense	probably damaging	0.98
IGL03141:Vmn2r110	APN	17	20,803,976 (GRCm39)	missense	possibly damaging	0.79
IGL03270:Vmn2r110	APN	17	20,803,778 (GRCm39)	missense	probably benign	0.00
IGL03286:Vmn2r110	APN	17	20,804,468 (GRCm39)	missense	possibly damaging	0.95
IGL03379:Vmn2r110	APN	17	20,803,906 (GRCm39)	missense	probably damaging	0.99
PIT4243001:Vmn2r110	UTSW	17	20,802,379 (GRCm39)	missense	probably benign	0.01
R0040:Vmn2r110	UTSW	17	20,816,346 (GRCm39)	missense	probably benign	0.10
R0195:Vmn2r110	UTSW	17	20,794,317 (GRCm39)	missense	probably benign	0.31
R0716:Vmn2r110	UTSW	17	20,794,165 (GRCm39)	missense	probably damaging	0.99
R1199:Vmn2r110	UTSW	17	20,803,525 (GRCm39)	missense	probably benign	0.03
R1767:Vmn2r110	UTSW	17	20,800,840 (GRCm39)	missense	possibly damaging	0.83
R2212:Vmn2r110	UTSW	17	20,794,209 (GRCm39)	splice site	probably null
R3056:Vmn2r110	UTSW	17	20,803,360 (GRCm39)	missense	probably damaging	1.00
R4093:Vmn2r110	UTSW	17	20,803,642 (GRCm39)	missense	possibly damaging	0.83
R4418:Vmn2r110	UTSW	17	20,803,951 (GRCm39)	nonsense	probably null
R4754:Vmn2r110	UTSW	17	20,816,458 (GRCm39)	missense	probably benign	0.00
R5283:Vmn2r110	UTSW	17	20,800,899 (GRCm39)	missense	probably benign	0.00
R5421:Vmn2r110	UTSW	17	20,803,882 (GRCm39)	missense	probably damaging	1.00
R5672:Vmn2r110	UTSW	17	20,816,494 (GRCm39)	missense	probably benign
R5865:Vmn2r110	UTSW	17	20,804,557 (GRCm39)	missense	probably benign	0.00
R6642:Vmn2r110	UTSW	17	20,803,779 (GRCm39)	missense	possibly damaging	0.94
R6799:Vmn2r110	UTSW	17	20,803,798 (GRCm39)	missense	probably benign
R7167:Vmn2r110	UTSW	17	20,794,441 (GRCm39)	missense	probably benign	0.01
R7291:Vmn2r110	UTSW	17	20,794,471 (GRCm39)	missense	probably benign	0.13
R7320:Vmn2r110	UTSW	17	20,816,316 (GRCm39)	missense	probably benign
R7519:Vmn2r110	UTSW	17	20,804,524 (GRCm39)	missense	probably benign
R8089:Vmn2r110	UTSW	17	20,803,807 (GRCm39)	missense	probably benign	0.00
R8234:Vmn2r110	UTSW	17	20,804,691 (GRCm39)	missense	probably benign	0.12
R8272:Vmn2r110	UTSW	17	20,816,490 (GRCm39)	missense	probably damaging	0.97
R8307:Vmn2r110	UTSW	17	20,803,319 (GRCm39)	missense	probably benign	0.00
R8506:Vmn2r110	UTSW	17	20,804,627 (GRCm39)	missense	probably benign	0.00
R8516:Vmn2r110	UTSW	17	20,794,875 (GRCm39)	missense	probably damaging	1.00
R8555:Vmn2r110	UTSW	17	20,804,618 (GRCm39)	missense	probably damaging	0.97
R8691:Vmn2r110	UTSW	17	20,803,404 (GRCm39)	missense	probably benign	0.19
R8859:Vmn2r110	UTSW	17	20,794,560 (GRCm39)	missense	probably damaging	0.99
R8935:Vmn2r110	UTSW	17	20,803,957 (GRCm39)	missense	probably benign	0.40
R8986:Vmn2r110	UTSW	17	20,803,823 (GRCm39)	missense	probably damaging	0.97
R9012:Vmn2r110	UTSW	17	20,803,627 (GRCm39)	missense	probably damaging	1.00
R9101:Vmn2r110	UTSW	17	20,794,471 (GRCm39)	missense
R9744:Vmn2r110	UTSW	17	20,794,848 (GRCm39)	missense	probably damaging	0.98
R9803:Vmn2r110	UTSW	17	20,803,730 (GRCm39)	missense	probably benign	0.00
Z1088:Vmn2r110	UTSW	17	20,803,942 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GTGAGTGAATCAACATCACCG -3'
(R):5'- CCTTGAAACTAACAGGCTTGGG -3'

Sequencing Primer
(F):5'- CAAAAGCTATGCAGACTCCTTTTC -3'
(R):5'- ACTAACAGGCTTGGGAGGAATTTTTG -3'

Posted On

2015-09-25