Incidental Mutation 'IGL01939:Dctn4'
ID180816
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dctn4
Ensembl Gene ENSMUSG00000024603
Gene Namedynactin 4
Synonymsp62, 1110001K06Rik, 4930547K17Rik, C130039E17Rik
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.940) question?
Stock #IGL01939
Quality Score
Status
Chromosome18
Chromosomal Location60526185-60558766 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 60544130 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Lysine at position 174 (M174K)
Ref Sequence ENSEMBL: ENSMUSP00000153008 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025505] [ENSMUST00000223984]
Predicted Effect probably benign
Transcript: ENSMUST00000025505
AA Change: M174K

PolyPhen 2 Score 0.119 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000025505
Gene: ENSMUSG00000024603
AA Change: M174K

DomainStartEndE-ValueType
Pfam:Dynactin_p62 23 172 4.8e-24 PFAM
Pfam:Dynactin_p62 125 378 8e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223794
Predicted Effect probably benign
Transcript: ENSMUST00000223984
AA Change: M174K

PolyPhen 2 Score 0.119 (Sensitivity: 0.93; Specificity: 0.86)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224317
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224778
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225005
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb2 G T 4: 129,992,132 D22Y probably damaging Het
Ak7 T C 12: 105,734,924 V242A probably benign Het
Cacna1b T C 2: 24,661,757 N1127S probably damaging Het
Cacnb2 A T 2: 14,971,569 H267L probably benign Het
Ces1b C T 8: 93,079,431 G61R probably damaging Het
Cgnl1 T A 9: 71,725,004 D355V probably damaging Het
Col24a1 T C 3: 145,315,244 S459P probably damaging Het
Crygd T C 1: 65,062,026 T137A probably benign Het
Evi5 A G 5: 107,816,924 probably benign Het
Fat2 T G 11: 55,283,980 D1969A probably benign Het
Fcrl5 A T 3: 87,446,299 E317V probably damaging Het
Foxf2 G T 13: 31,626,714 S212I probably damaging Het
Gm21759 T A 5: 8,180,685 probably benign Het
Gm5414 A G 15: 101,625,670 probably benign Het
Gm7275 T C 16: 48,073,583 noncoding transcript Het
Hspa9 T C 18: 34,938,708 E613G possibly damaging Het
Il1rl1 A G 1: 40,462,008 I515V possibly damaging Het
Ins1 G T 19: 52,264,735 A38S probably damaging Het
Klhl31 A G 9: 77,655,206 N418D probably benign Het
Magi3 T C 3: 104,054,462 K417E probably damaging Het
Msh4 A G 3: 153,857,589 Y823H probably damaging Het
Myo6 T A 9: 80,260,818 D421E probably damaging Het
Myom3 T C 4: 135,765,589 S150P possibly damaging Het
Nectin1 C T 9: 43,792,574 probably benign Het
Nkx1-2 A T 7: 132,599,474 I18N probably damaging Het
Olfr1006 T C 2: 85,674,941 D70G probably damaging Het
Olfr1193 A G 2: 88,678,733 T286A probably damaging Het
Olfr1467 A T 19: 13,365,443 I272F probably benign Het
Olfr952 A C 9: 39,426,338 H244Q probably damaging Het
Pde8b T C 13: 95,095,724 R237G probably damaging Het
Pp2d1 G A 17: 53,515,139 L300F probably damaging Het
Ptpn21 A T 12: 98,689,161 Y516N probably damaging Het
Ptprm T A 17: 67,063,163 probably benign Het
Rabggtb A G 3: 153,912,013 V16A probably damaging Het
Rangap1 A T 15: 81,720,663 C82S probably damaging Het
Rasal2 T C 1: 157,175,910 E393G probably damaging Het
Rasgrf1 A T 9: 89,974,836 E449V probably damaging Het
Rrp12 A T 19: 41,870,895 H1143Q probably damaging Het
Scap T C 9: 110,379,481 I530T probably benign Het
Sel1l T A 12: 91,816,247 Q482L probably damaging Het
Serpinb9b T C 13: 33,039,665 M280T probably damaging Het
Slc39a10 T A 1: 46,832,735 H348L probably benign Het
Slc7a2 T C 8: 40,914,083 L542P possibly damaging Het
Tas1r2 A T 4: 139,669,177 Q609L probably damaging Het
Tbc1d14 A T 5: 36,508,437 probably benign Het
Tfb2m A G 1: 179,537,697 probably null Het
Tpo T C 12: 30,084,647 T771A possibly damaging Het
Tpr G A 1: 150,413,745 R609H possibly damaging Het
Usp34 T A 11: 23,345,141 probably benign Het
Vmn1r193 G T 13: 22,219,723 S33* probably null Het
Vmn2r104 A C 17: 20,029,925 S695A probably damaging Het
Vmn2r24 A G 6: 123,787,445 D427G probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Zfp362 A G 4: 128,787,053 S160P probably benign Het
Other mutations in Dctn4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0040:Dctn4 UTSW 18 60544042 missense possibly damaging 0.71
R1406:Dctn4 UTSW 18 60556330 missense probably benign
R1406:Dctn4 UTSW 18 60556330 missense probably benign
R1464:Dctn4 UTSW 18 60538406 missense probably damaging 0.97
R1464:Dctn4 UTSW 18 60538406 missense probably damaging 0.97
R1785:Dctn4 UTSW 18 60546335 critical splice donor site probably null
R1786:Dctn4 UTSW 18 60546335 critical splice donor site probably null
R2035:Dctn4 UTSW 18 60538417 missense possibly damaging 0.91
R2064:Dctn4 UTSW 18 60538277 missense possibly damaging 0.60
R4020:Dctn4 UTSW 18 60538257 splice site probably benign
R4748:Dctn4 UTSW 18 60550236 missense probably damaging 1.00
R4786:Dctn4 UTSW 18 60555195 missense probably damaging 1.00
R4976:Dctn4 UTSW 18 60556392 missense probably benign 0.00
R5034:Dctn4 UTSW 18 60552884 missense probably benign 0.23
R5110:Dctn4 UTSW 18 60546315 missense probably damaging 0.96
R6210:Dctn4 UTSW 18 60546793 nonsense probably null
Posted On2014-05-07