Incidental Mutation 'R1956:Cadps2'
| ID |
217784 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cadps2
|
| Ensembl Gene |
ENSMUSG00000017978 |
| Gene Name |
Ca2+-dependent activator protein for secretion 2 |
| Synonyms |
Caps2, A230044C21Rik, cpd2 |
| MMRRC Submission |
039970-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1956 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
23262772-23839420 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 23287685 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 1160
(M1160K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000111018
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000018122]
[ENSMUST00000069074]
[ENSMUST00000115358]
[ENSMUST00000115361]
[ENSMUST00000125350]
[ENSMUST00000142913]
[ENSMUST00000163871]
[ENSMUST00000166458]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000018122
AA Change: M1205K
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000018122
Gene: ENSMUSG00000017978
AA Change: M1205K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
1.14e-52 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000069074
AA Change: M1198K
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000064876
Gene: ENSMUSG00000017978
AA Change: M1198K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
895 |
5.54e-51 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115358
AA Change: M1165K
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000111015
Gene: ENSMUSG00000017978
AA Change: M1165K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
1.14e-52 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115361
AA Change: M1160K
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000111018
Gene: ENSMUSG00000017978
AA Change: M1160K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
892 |
1.9e-49 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000125350
AA Change: M800K
PolyPhen 2
Score 0.218 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000115866
Gene: ENSMUSG00000017978
AA Change: M800K
| Domain | Start | End | E-Value | Type |
|---|
|
C2
|
14 |
112 |
1.51e-1 |
SMART |
|
PH
|
137 |
241 |
2.94e-11 |
SMART |
|
DUF1041
|
446 |
537 |
1.9e-49 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000142913
AA Change: M1176K
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000138167
Gene: ENSMUSG00000017978
AA Change: M1176K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
22 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
85 |
97 |
N/A |
INTRINSIC |
|
coiled coil region
|
236 |
256 |
N/A |
INTRINSIC |
|
C2
|
340 |
438 |
1.51e-1 |
SMART |
|
PH
|
463 |
567 |
2.94e-11 |
SMART |
|
DUF1041
|
772 |
873 |
1.14e-52 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000152131
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163871
AA Change: M1205K
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000128905
Gene: ENSMUSG00000017978
AA Change: M1205K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
7.2e-50 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000166458
AA Change: M1176K
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000125972
Gene: ENSMUSG00000017978
AA Change: M1176K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
85 |
97 |
N/A |
INTRINSIC |
|
coiled coil region
|
236 |
256 |
N/A |
INTRINSIC |
|
C2
|
340 |
438 |
1.51e-1 |
SMART |
|
PH
|
463 |
567 |
2.94e-11 |
SMART |
|
DUF1041
|
772 |
873 |
1.05e-51 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000156986
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
PHENOTYPE: Mice homozygous for a null allele exhibit defects in cerebellum, Purkinje cell and interneuron morphology, paired-pulse facilitation, and behaviors including emotional behavior, vestibuoocular reflex, circadium and sleep patterns, social investigation and nurturing behavior. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 102 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aard |
A |
T |
15: 51,908,316 (GRCm39) |
D157V |
probably damaging |
Het |
| Abcg5 |
A |
G |
17: 84,977,803 (GRCm39) |
V151A |
probably damaging |
Het |
| Acss3 |
A |
G |
10: 106,772,029 (GRCm39) |
V682A |
probably benign |
Het |
| Adamts9 |
A |
T |
6: 92,836,830 (GRCm39) |
C641S |
probably damaging |
Het |
| Adipor1 |
T |
C |
1: 134,350,771 (GRCm39) |
S7P |
probably benign |
Het |
| Ankrd27 |
T |
A |
7: 35,303,264 (GRCm39) |
Y215N |
probably damaging |
Het |
| Arhgef7 |
T |
A |
8: 11,855,266 (GRCm39) |
L182Q |
probably damaging |
Het |
| Arnt |
C |
T |
3: 95,355,704 (GRCm39) |
S16L |
possibly damaging |
Het |
| Arrdc4 |
T |
C |
7: 68,391,547 (GRCm39) |
K240R |
probably benign |
Het |
| Atg2b |
T |
C |
12: 105,635,677 (GRCm39) |
Y197C |
probably damaging |
Het |
| Atp13a2 |
A |
G |
4: 140,731,572 (GRCm39) |
K907R |
possibly damaging |
Het |
| Cdk12 |
A |
G |
11: 98,110,042 (GRCm39) |
T688A |
probably benign |
Het |
| Cfap43 |
T |
A |
19: 47,885,649 (GRCm39) |
Y322F |
probably benign |
Het |
| Crabp2 |
T |
C |
3: 87,856,193 (GRCm39) |
F16L |
probably damaging |
Het |
| Creb3 |
A |
G |
4: 43,563,279 (GRCm39) |
|
probably null |
Het |
| Crk |
T |
C |
11: 75,583,496 (GRCm39) |
Y239H |
possibly damaging |
Het |
| Cyp3a13 |
A |
G |
5: 137,908,204 (GRCm39) |
I215T |
probably benign |
Het |
| D130043K22Rik |
A |
G |
13: 25,069,578 (GRCm39) |
Y879C |
probably damaging |
Het |
| Depdc5 |
T |
C |
5: 33,061,175 (GRCm39) |
V334A |
probably damaging |
Het |
| Dgkh |
T |
C |
14: 78,855,981 (GRCm39) |
N231S |
probably damaging |
Het |
| Disp2 |
T |
A |
2: 118,622,704 (GRCm39) |
H1145Q |
probably benign |
Het |
| Epb41l4b |
T |
C |
4: 57,038,553 (GRCm39) |
T563A |
possibly damaging |
Het |
| Ephb3 |
G |
A |
16: 21,040,132 (GRCm39) |
R498H |
probably damaging |
Het |
| F10 |
T |
C |
8: 13,105,422 (GRCm39) |
I329T |
probably damaging |
Het |
| Fam13b |
G |
T |
18: 34,578,382 (GRCm39) |
Q760K |
possibly damaging |
Het |
| Fmo4 |
G |
A |
1: 162,631,259 (GRCm39) |
T236I |
probably benign |
Het |
| Foxp4 |
C |
T |
17: 48,186,796 (GRCm39) |
R378Q |
unknown |
Het |
| Fpr-rs4 |
A |
G |
17: 18,242,518 (GRCm39) |
Y175C |
probably damaging |
Het |
| Fzd8 |
T |
A |
18: 9,214,502 (GRCm39) |
M528K |
probably damaging |
Het |
| Gcc2 |
A |
G |
10: 58,121,965 (GRCm39) |
H1134R |
possibly damaging |
Het |
| Gdf10 |
G |
A |
14: 33,654,710 (GRCm39) |
A406T |
probably benign |
Het |
| Ggn |
T |
A |
7: 28,871,341 (GRCm39) |
S240R |
probably damaging |
Het |
| Git2 |
C |
T |
5: 114,887,398 (GRCm39) |
W299* |
probably null |
Het |
| Gm42669 |
A |
T |
5: 107,656,738 (GRCm39) |
E355D |
possibly damaging |
Het |
| Gm5134 |
T |
C |
10: 75,840,680 (GRCm39) |
F508S |
possibly damaging |
Het |
| Gm9923 |
G |
T |
10: 72,145,490 (GRCm39) |
V114L |
probably benign |
Het |
| Has3 |
A |
T |
8: 107,605,435 (GRCm39) |
Y547F |
probably benign |
Het |
| Heatr5a |
A |
G |
12: 51,992,202 (GRCm39) |
|
probably null |
Het |
| Hnrnpk |
A |
T |
13: 58,544,000 (GRCm39) |
|
probably null |
Het |
| Ifna4 |
A |
T |
4: 88,760,311 (GRCm39) |
I72F |
probably damaging |
Het |
| Ip6k3 |
A |
T |
17: 27,370,142 (GRCm39) |
L92Q |
probably benign |
Het |
| Itpripl1 |
T |
C |
2: 126,983,927 (GRCm39) |
E65G |
probably damaging |
Het |
| Kcnh5 |
G |
C |
12: 74,944,358 (GRCm39) |
Q964E |
probably benign |
Het |
| Kmt2d |
A |
G |
15: 98,757,471 (GRCm39) |
|
probably benign |
Het |
| Lrrc69 |
A |
G |
4: 14,665,986 (GRCm39) |
V324A |
possibly damaging |
Het |
| Mefv |
T |
C |
16: 3,535,691 (GRCm39) |
Q79R |
probably damaging |
Het |
| Mettl17 |
T |
C |
14: 52,126,254 (GRCm39) |
S168P |
probably damaging |
Het |
| Mpp4 |
A |
T |
1: 59,197,811 (GRCm39) |
S23T |
probably benign |
Het |
| Nabp1 |
A |
T |
1: 51,517,004 (GRCm39) |
V24D |
probably damaging |
Het |
| Nod2 |
T |
A |
8: 89,390,836 (GRCm39) |
F359Y |
probably damaging |
Het |
| Or10g1b |
C |
T |
14: 52,628,037 (GRCm39) |
M64I |
probably benign |
Het |
| Or1p1c |
A |
T |
11: 74,160,670 (GRCm39) |
T152S |
probably damaging |
Het |
| Or51b17 |
T |
G |
7: 103,542,925 (GRCm39) |
S6R |
probably benign |
Het |
| Or52d3 |
C |
A |
7: 104,229,116 (GRCm39) |
L88M |
probably damaging |
Het |
| Or5ak4 |
T |
C |
2: 85,161,444 (GRCm39) |
D266G |
probably benign |
Het |
| Or5b107 |
T |
C |
19: 13,142,560 (GRCm39) |
Y61H |
probably damaging |
Het |
| Or6a2 |
C |
T |
7: 106,600,342 (GRCm39) |
A242T |
probably damaging |
Het |
| Or7a39 |
A |
G |
10: 78,715,267 (GRCm39) |
Q87R |
probably benign |
Het |
| Pcdh18 |
T |
C |
3: 49,710,400 (GRCm39) |
H305R |
probably benign |
Het |
| Phf1 |
T |
A |
17: 27,154,719 (GRCm39) |
|
probably null |
Het |
| Pold3 |
T |
C |
7: 99,737,318 (GRCm39) |
K379R |
probably benign |
Het |
| Polr1f |
T |
A |
12: 33,487,817 (GRCm39) |
V244D |
probably benign |
Het |
| Pou2f3 |
T |
A |
9: 43,056,534 (GRCm39) |
T108S |
probably benign |
Het |
| Prdm5 |
C |
A |
6: 65,913,060 (GRCm39) |
T203K |
probably damaging |
Het |
| Psma5 |
A |
G |
3: 108,173,760 (GRCm39) |
S79G |
probably benign |
Het |
| Psme4 |
T |
A |
11: 30,782,424 (GRCm39) |
S889T |
probably damaging |
Het |
| Ptk2 |
A |
T |
15: 73,087,832 (GRCm39) |
V902D |
possibly damaging |
Het |
| Rad54l |
T |
A |
4: 115,967,554 (GRCm39) |
I243F |
probably damaging |
Het |
| Ralgapa2 |
A |
G |
2: 146,302,679 (GRCm39) |
F95L |
probably benign |
Het |
| Rassf6 |
G |
A |
5: 90,763,730 (GRCm39) |
Q71* |
probably null |
Het |
| Ryr2 |
A |
T |
13: 11,695,966 (GRCm39) |
L2967H |
probably damaging |
Het |
| Scn5a |
T |
C |
9: 119,346,479 (GRCm39) |
T1058A |
possibly damaging |
Het |
| Sdk1 |
T |
C |
5: 142,080,336 (GRCm39) |
L1276P |
probably damaging |
Het |
| Serpina12 |
T |
G |
12: 104,002,048 (GRCm39) |
T223P |
probably damaging |
Het |
| Sh3yl1 |
A |
G |
12: 30,992,787 (GRCm39) |
|
probably null |
Het |
| Spata31g1 |
A |
T |
4: 42,970,105 (GRCm39) |
|
probably null |
Het |
| St6galnac5 |
T |
A |
3: 152,552,120 (GRCm39) |
Q149L |
probably benign |
Het |
| Stam2 |
T |
C |
2: 52,598,239 (GRCm39) |
|
probably null |
Het |
| Tac2 |
A |
G |
10: 127,564,349 (GRCm39) |
|
probably null |
Het |
| Tbata |
G |
A |
10: 61,019,256 (GRCm39) |
D271N |
probably damaging |
Het |
| Tbx3 |
T |
C |
5: 119,819,018 (GRCm39) |
V531A |
probably benign |
Het |
| Tektl1 |
A |
G |
10: 78,586,373 (GRCm39) |
|
probably null |
Het |
| Thra |
T |
A |
11: 98,654,567 (GRCm39) |
D312E |
probably benign |
Het |
| Tlr1 |
T |
A |
5: 65,082,520 (GRCm39) |
I686F |
probably damaging |
Het |
| Tmem86b |
A |
T |
7: 4,631,706 (GRCm39) |
F115L |
probably benign |
Het |
| Tmem94 |
A |
G |
11: 115,679,500 (GRCm39) |
D259G |
possibly damaging |
Het |
| Trim69 |
G |
A |
2: 122,004,956 (GRCm39) |
|
probably null |
Het |
| Usp43 |
T |
A |
11: 67,795,159 (GRCm39) |
Q243L |
probably damaging |
Het |
| Vcam1 |
T |
C |
3: 115,919,606 (GRCm39) |
Y226C |
probably damaging |
Het |
| Vmn2r104 |
A |
T |
17: 20,262,313 (GRCm39) |
N272K |
probably damaging |
Het |
| Vmn2r26 |
G |
A |
6: 124,030,846 (GRCm39) |
C527Y |
probably damaging |
Het |
| Vmn2r84 |
G |
A |
10: 130,226,677 (GRCm39) |
A387V |
probably benign |
Het |
| Vps13b |
A |
T |
15: 35,869,553 (GRCm39) |
I2686F |
probably damaging |
Het |
| Vps8 |
C |
T |
16: 21,279,892 (GRCm39) |
T281M |
probably damaging |
Het |
| Wdfy3 |
A |
G |
5: 102,067,275 (GRCm39) |
V1219A |
probably benign |
Het |
| Wnt9b |
A |
G |
11: 103,621,638 (GRCm39) |
C340R |
probably damaging |
Het |
| Zfhx3 |
T |
C |
8: 109,520,774 (GRCm39) |
V632A |
probably benign |
Het |
| Zfp1006 |
A |
T |
8: 129,948,309 (GRCm39) |
D41E |
possibly damaging |
Het |
| Zfp341 |
A |
T |
2: 154,480,132 (GRCm39) |
T528S |
probably benign |
Het |
| Zfp990 |
G |
A |
4: 145,261,452 (GRCm39) |
A33T |
probably damaging |
Het |
| Zranb1 |
T |
G |
7: 132,584,458 (GRCm39) |
S601R |
probably damaging |
Het |
| Zyx |
A |
T |
6: 42,328,289 (GRCm39) |
K166I |
probably damaging |
Het |
|
| Other mutations in Cadps2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01014:Cadps2
|
APN |
6 |
23,496,873 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL01105:Cadps2
|
APN |
6 |
23,321,699 (GRCm39) |
splice site |
probably benign |
|
|
IGL01317:Cadps2
|
APN |
6 |
23,314,172 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
IGL01409:Cadps2
|
APN |
6 |
23,587,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01477:Cadps2
|
APN |
6 |
23,263,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01620:Cadps2
|
APN |
6 |
23,587,461 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL01674:Cadps2
|
APN |
6 |
23,355,851 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01675:Cadps2
|
APN |
6 |
23,382,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01895:Cadps2
|
APN |
6 |
23,427,274 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02095:Cadps2
|
APN |
6 |
23,427,309 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02200:Cadps2
|
APN |
6 |
23,385,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02380:Cadps2
|
APN |
6 |
23,287,731 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02680:Cadps2
|
APN |
6 |
23,838,895 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02814:Cadps2
|
APN |
6 |
23,321,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02940:Cadps2
|
APN |
6 |
23,496,808 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL03061:Cadps2
|
APN |
6 |
23,287,659 (GRCm39) |
splice site |
probably null |
|
|
IGL03233:Cadps2
|
APN |
6 |
23,263,600 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0193:Cadps2
|
UTSW |
6 |
23,599,439 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0389:Cadps2
|
UTSW |
6 |
23,321,781 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0571:Cadps2
|
UTSW |
6 |
23,583,411 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0595:Cadps2
|
UTSW |
6 |
23,321,703 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0620:Cadps2
|
UTSW |
6 |
23,583,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0723:Cadps2
|
UTSW |
6 |
23,287,697 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0831:Cadps2
|
UTSW |
6 |
23,321,739 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0836:Cadps2
|
UTSW |
6 |
23,328,775 (GRCm39) |
splice site |
probably benign |
|
|
R0942:Cadps2
|
UTSW |
6 |
23,263,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1099:Cadps2
|
UTSW |
6 |
23,599,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1120:Cadps2
|
UTSW |
6 |
23,838,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1216:Cadps2
|
UTSW |
6 |
23,583,472 (GRCm39) |
splice site |
probably benign |
|
|
R1575:Cadps2
|
UTSW |
6 |
23,429,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1780:Cadps2
|
UTSW |
6 |
23,320,931 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1924:Cadps2
|
UTSW |
6 |
23,688,857 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1944:Cadps2
|
UTSW |
6 |
23,599,479 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1986:Cadps2
|
UTSW |
6 |
23,323,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2045:Cadps2
|
UTSW |
6 |
23,839,121 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2146:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2147:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2148:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2150:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2219:Cadps2
|
UTSW |
6 |
23,410,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2264:Cadps2
|
UTSW |
6 |
23,323,339 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2338:Cadps2
|
UTSW |
6 |
23,838,977 (GRCm39) |
splice site |
probably benign |
|
|
R3861:Cadps2
|
UTSW |
6 |
23,355,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3898:Cadps2
|
UTSW |
6 |
23,528,125 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3982:Cadps2
|
UTSW |
6 |
23,263,530 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4213:Cadps2
|
UTSW |
6 |
23,599,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4384:Cadps2
|
UTSW |
6 |
23,412,987 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4432:Cadps2
|
UTSW |
6 |
23,626,737 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4609:Cadps2
|
UTSW |
6 |
23,587,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4806:Cadps2
|
UTSW |
6 |
23,688,859 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4977:Cadps2
|
UTSW |
6 |
23,599,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5174:Cadps2
|
UTSW |
6 |
23,287,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5267:Cadps2
|
UTSW |
6 |
23,626,667 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5389:Cadps2
|
UTSW |
6 |
23,329,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5737:Cadps2
|
UTSW |
6 |
23,328,804 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6074:Cadps2
|
UTSW |
6 |
23,626,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6254:Cadps2
|
UTSW |
6 |
23,329,162 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6323:Cadps2
|
UTSW |
6 |
23,263,577 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6463:Cadps2
|
UTSW |
6 |
23,323,333 (GRCm39) |
nonsense |
probably null |
|
|
R6907:Cadps2
|
UTSW |
6 |
23,599,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6940:Cadps2
|
UTSW |
6 |
23,302,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6964:Cadps2
|
UTSW |
6 |
23,583,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7079:Cadps2
|
UTSW |
6 |
23,323,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7139:Cadps2
|
UTSW |
6 |
23,410,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7156:Cadps2
|
UTSW |
6 |
23,688,955 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7184:Cadps2
|
UTSW |
6 |
23,583,428 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7325:Cadps2
|
UTSW |
6 |
23,409,934 (GRCm39) |
missense |
unknown |
|
|
R7526:Cadps2
|
UTSW |
6 |
23,496,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7546:Cadps2
|
UTSW |
6 |
23,626,607 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7772:Cadps2
|
UTSW |
6 |
23,390,445 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7870:Cadps2
|
UTSW |
6 |
23,263,641 (GRCm39) |
missense |
probably benign |
0.14 |
|
R8040:Cadps2
|
UTSW |
6 |
23,412,942 (GRCm39) |
splice site |
probably benign |
|
|
R8048:Cadps2
|
UTSW |
6 |
23,838,862 (GRCm39) |
missense |
probably benign |
0.14 |
|
R8082:Cadps2
|
UTSW |
6 |
23,323,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8100:Cadps2
|
UTSW |
6 |
23,838,808 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8115:Cadps2
|
UTSW |
6 |
23,328,897 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8497:Cadps2
|
UTSW |
6 |
23,355,918 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8768:Cadps2
|
UTSW |
6 |
23,382,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8783:Cadps2
|
UTSW |
6 |
23,302,303 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R8804:Cadps2
|
UTSW |
6 |
23,496,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8832:Cadps2
|
UTSW |
6 |
23,587,536 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8848:Cadps2
|
UTSW |
6 |
23,344,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8854:Cadps2
|
UTSW |
6 |
23,385,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8896:Cadps2
|
UTSW |
6 |
23,410,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8910:Cadps2
|
UTSW |
6 |
23,344,223 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8921:Cadps2
|
UTSW |
6 |
23,302,300 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9228:Cadps2
|
UTSW |
6 |
23,688,927 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9297:Cadps2
|
UTSW |
6 |
23,496,887 (GRCm39) |
missense |
probably benign |
|
|
R9318:Cadps2
|
UTSW |
6 |
23,496,887 (GRCm39) |
missense |
probably benign |
|
|
R9348:Cadps2
|
UTSW |
6 |
23,344,262 (GRCm39) |
missense |
probably benign |
0.20 |
|
R9447:Cadps2
|
UTSW |
6 |
23,323,297 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9484:Cadps2
|
UTSW |
6 |
23,626,646 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9492:Cadps2
|
UTSW |
6 |
23,427,238 (GRCm39) |
missense |
probably benign |
|
|
R9630:Cadps2
|
UTSW |
6 |
23,587,571 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9729:Cadps2
|
UTSW |
6 |
23,382,982 (GRCm39) |
missense |
probably benign |
0.28 |
|
Z1176:Cadps2
|
UTSW |
6 |
23,321,800 (GRCm39) |
missense |
probably benign |
0.24 |
|
Z1177:Cadps2
|
UTSW |
6 |
23,838,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Cadps2
|
UTSW |
6 |
23,626,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Cadps2
|
UTSW |
6 |
23,385,477 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
| Predicted Primers |
PCR Primer
(F):5'- TAGTTACGAGTGATGGACAACAC -3'
(R):5'- GGGTGAACAATTCCAACAGC -3'
Sequencing Primer
(F):5'- GACAACACTGATATTAAGTCAAGTGC -3'
(R):5'- TCCAACAGCTATGAAAATGATTTCC -3'
|
| Posted On |
2014-08-01 |
Incidental Mutation