Incidental Mutation 'IGL02106:Or4m1'
ID 279996
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or4m1
Ensembl Gene ENSMUSG00000045306
Gene Name olfactory receptor family 4 subfamily M member 1
Synonyms Olfr734, GA_x6K02T2PMLR-6013665-6012724, MOR242-1
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.495) question?
Stock # IGL02106
Quality Score
Status
Chromosome 14
Chromosomal Location 50557293-50558325 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 50557617 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Histidine at position 225 (L225H)
Ref Sequence ENSEMBL: ENSMUSP00000150732 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050928] [ENSMUST00000217152]
AlphaFold Q8VFT4
Predicted Effect probably damaging
Transcript: ENSMUST00000050928
AA Change: L225H

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000057376
Gene: ENSMUSG00000045306
AA Change: L225H

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.3e-39 PFAM
Pfam:7tm_1 41 302 4.1e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216732
Predicted Effect probably damaging
Transcript: ENSMUST00000217152
AA Change: L225H

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bcl9l A G 9: 44,420,496 (GRCm39) N1264D probably benign Het
Bmyc A G 2: 25,597,082 (GRCm39) K49E probably damaging Het
Cdc45 C T 16: 18,617,479 (GRCm39) M200I probably benign Het
Ceacam2 A G 7: 25,230,166 (GRCm39) S147P probably benign Het
Cep152 G T 2: 125,444,856 (GRCm39) probably null Het
Cnbd1 G T 4: 18,894,993 (GRCm39) P250T possibly damaging Het
Col6a4 A G 9: 105,940,304 (GRCm39) C1209R possibly damaging Het
Coro1c T C 5: 113,990,334 (GRCm39) T116A probably benign Het
Ddx46 A G 13: 55,825,416 (GRCm39) probably benign Het
Dnaaf5 T C 5: 139,137,268 (GRCm39) I207T probably damaging Het
Erap1 A G 13: 74,794,758 (GRCm39) D139G probably benign Het
Fbxw22 A T 9: 109,231,087 (GRCm39) I121N possibly damaging Het
Fcmr T C 1: 130,802,872 (GRCm39) S162P probably benign Het
Gadl1 A G 9: 115,766,225 (GRCm39) probably benign Het
Gli2 T A 1: 118,764,465 (GRCm39) S1229C probably benign Het
Gm10717 A T 9: 3,026,287 (GRCm39) Y195F probably damaging Het
Gne T C 4: 44,037,306 (GRCm39) N692D probably damaging Het
Knl1 A G 2: 118,902,489 (GRCm39) T1397A possibly damaging Het
Lama3 C A 18: 12,601,371 (GRCm39) A1016E probably damaging Het
Lhfpl2 A G 13: 94,328,419 (GRCm39) D160G probably benign Het
Lmtk2 T A 5: 144,112,769 (GRCm39) V1163E probably benign Het
Lrrtm2 G T 18: 35,345,868 (GRCm39) S478* probably null Het
Nfatc2ip T C 7: 125,989,736 (GRCm39) probably null Het
Nlrp12 A G 7: 3,282,574 (GRCm39) I775T probably benign Het
Npr1 A G 3: 90,372,165 (GRCm39) F216L probably benign Het
Or5ac24 T A 16: 59,165,387 (GRCm39) N226Y probably benign Het
Or5b99 G T 19: 12,976,929 (GRCm39) S193I possibly damaging Het
Pkd1l1 C A 11: 8,783,800 (GRCm39) G2052C probably damaging Het
Ppp1r16b A G 2: 158,588,451 (GRCm39) N112S possibly damaging Het
Prr11 A G 11: 86,994,141 (GRCm39) probably benign Het
Scap A G 9: 110,210,724 (GRCm39) probably benign Het
Sirt1 C T 10: 63,171,608 (GRCm39) R191Q probably damaging Het
Slc38a6 A C 12: 73,397,320 (GRCm39) S321R possibly damaging Het
Sp140 T C 1: 85,570,940 (GRCm39) V460A probably benign Het
Spdye4c A T 2: 128,434,586 (GRCm39) K54N possibly damaging Het
Spta1 T A 1: 174,030,860 (GRCm39) N947K probably benign Het
Srgap1 A G 10: 121,621,598 (GRCm39) V965A possibly damaging Het
Tmem209 A C 6: 30,508,659 (GRCm39) probably null Het
Trim37 A T 11: 87,092,230 (GRCm39) K123* probably null Het
Trio T C 15: 27,744,244 (GRCm39) T2563A possibly damaging Het
Utrn A T 10: 12,289,717 (GRCm39) S734T possibly damaging Het
Vars2 A G 17: 35,975,513 (GRCm39) probably benign Het
Xrn1 G A 9: 95,859,858 (GRCm39) E417K probably benign Het
Yeats2 T A 16: 20,011,970 (GRCm39) V515E possibly damaging Het
Other mutations in Or4m1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01140:Or4m1 APN 14 50,557,732 (GRCm39) missense probably damaging 0.96
IGL01285:Or4m1 APN 14 50,557,713 (GRCm39) missense possibly damaging 0.88
IGL02313:Or4m1 APN 14 50,557,473 (GRCm39) missense probably damaging 0.99
IGL03125:Or4m1 APN 14 50,558,149 (GRCm39) missense probably benign 0.01
R0276:Or4m1 UTSW 14 50,557,636 (GRCm39) missense probably benign 0.23
R0547:Or4m1 UTSW 14 50,557,575 (GRCm39) missense probably benign 0.06
R0567:Or4m1 UTSW 14 50,558,115 (GRCm39) missense probably damaging 0.99
R0927:Or4m1 UTSW 14 50,558,186 (GRCm39) nonsense probably null
R1506:Or4m1 UTSW 14 50,557,941 (GRCm39) missense probably benign 0.00
R4032:Or4m1 UTSW 14 50,557,767 (GRCm39) missense possibly damaging 0.91
R5179:Or4m1 UTSW 14 50,557,993 (GRCm39) nonsense probably null
R5401:Or4m1 UTSW 14 50,557,566 (GRCm39) missense probably damaging 1.00
R6240:Or4m1 UTSW 14 50,558,043 (GRCm39) missense probably benign 0.00
R7752:Or4m1 UTSW 14 50,557,573 (GRCm39) missense probably damaging 1.00
R7901:Or4m1 UTSW 14 50,557,573 (GRCm39) missense probably damaging 1.00
R8034:Or4m1 UTSW 14 50,558,023 (GRCm39) missense probably damaging 1.00
R8260:Or4m1 UTSW 14 50,557,615 (GRCm39) missense probably benign 0.09
R8420:Or4m1 UTSW 14 50,558,233 (GRCm39) missense probably benign
R9056:Or4m1 UTSW 14 50,557,999 (GRCm39) missense probably damaging 0.98
R9128:Or4m1 UTSW 14 50,558,214 (GRCm39) missense probably benign 0.08
R9618:Or4m1 UTSW 14 50,557,760 (GRCm39) nonsense probably null
R9659:Or4m1 UTSW 14 50,558,181 (GRCm39) missense probably benign 0.10
R9788:Or4m1 UTSW 14 50,558,181 (GRCm39) missense probably benign 0.10
X0064:Or4m1 UTSW 14 50,557,511 (GRCm39) nonsense probably null
Posted On 2015-04-16