Incidental Mutation 'IGL02115:Gpr149'
ID280323
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr149
Ensembl Gene ENSMUSG00000043441
Gene NameG protein-coupled receptor 149
SynonymsPGR10, R35, Ieda, 9630018L10Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.075) question?
Stock #IGL02115
Quality Score
Status
Chromosome3
Chromosomal Location62529077-62605140 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 62594915 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 507 (T507A)
Ref Sequence ENSEMBL: ENSMUSP00000060893 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058535]
Predicted Effect probably benign
Transcript: ENSMUST00000058535
AA Change: T507A

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000060893
Gene: ENSMUSG00000043441
AA Change: T507A

DomainStartEndE-ValueType
Pfam:7tm_1 52 363 7.2e-7 PFAM
coiled coil region 694 730 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149007
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Female mice homozygous for a knock-out allele exhibit increased fertility with increased litter size and frequency. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933440M02Rik A T 7: 125,331,609 noncoding transcript Het
Abca7 A T 10: 79,998,079 N76Y probably damaging Het
Apob A G 12: 7,992,923 K755R probably benign Het
BC034090 A T 1: 155,232,651 probably benign Het
Brinp1 T C 4: 68,762,398 T632A probably benign Het
Cdcp1 C A 9: 123,185,397 C104F probably damaging Het
Cfap206 C T 4: 34,722,623 V153I possibly damaging Het
Chd1l A T 3: 97,589,904 probably null Het
Ckb A G 12: 111,669,981 F271L possibly damaging Het
Col6a3 T A 1: 90,807,651 I759L probably damaging Het
Ddr2 A T 1: 169,994,709 M390K probably benign Het
Dhx8 C T 11: 101,752,388 P762L probably damaging Het
Dnah3 A T 7: 120,029,054 V1449E probably damaging Het
Dzip3 T C 16: 48,948,485 I629M probably benign Het
Ep300 T C 15: 81,648,818 I1692T unknown Het
Ercc6 T A 14: 32,576,993 L1446Q probably damaging Het
Gm10092 T C 16: 36,137,623 noncoding transcript Het
Gm6900 A T 7: 10,656,576 noncoding transcript Het
Hmcn1 T A 1: 150,630,728 D3776V probably damaging Het
Irgm2 A G 11: 58,220,122 E225G probably benign Het
Kif14 T C 1: 136,496,567 probably benign Het
Klhl22 T C 16: 17,776,595 V196A probably damaging Het
Lig4 T C 8: 9,973,247 S178G possibly damaging Het
Lzts2 A G 19: 45,026,370 probably benign Het
Mcoln3 C T 3: 146,137,301 S380L probably damaging Het
Med12l A T 3: 59,068,319 T223S probably benign Het
Mrpl54 A G 10: 81,265,649 probably null Het
Myo1c A T 11: 75,661,591 I397F probably damaging Het
Nbas A T 12: 13,317,692 probably benign Het
Ncoa2 G A 1: 13,152,817 H1195Y probably damaging Het
Nol3 A G 8: 105,279,631 M171V probably benign Het
Olfr167 A T 16: 19,515,103 C178S probably damaging Het
Olfr593 A G 7: 103,212,474 T194A probably damaging Het
Pdpr C T 8: 111,103,998 L107F probably damaging Het
Ppfibp2 G A 7: 107,739,318 probably benign Het
Rusc2 T C 4: 43,426,136 probably benign Het
Sdk2 G T 11: 113,834,813 probably benign Het
Sema7a T C 9: 57,960,900 C539R probably damaging Het
Senp6 T C 9: 80,121,926 C524R probably damaging Het
Setdb2 C T 14: 59,402,315 R709Q probably damaging Het
Slc15a1 A T 14: 121,480,661 Y269N possibly damaging Het
Synj2 T A 17: 6,017,590 Y113N probably damaging Het
Tm6sf1 A T 7: 81,875,803 Y172F probably damaging Het
Trpv4 T C 5: 114,625,029 D773G probably damaging Het
Ttc39a A G 4: 109,426,294 probably benign Het
Tut1 C T 19: 8,965,312 R588W probably damaging Het
Unc79 A T 12: 102,998,674 Y74F probably damaging Het
Usp53 A T 3: 122,947,390 I737K probably benign Het
Vmn2r67 A T 7: 85,151,579 M383K probably damaging Het
Zc3h4 A G 7: 16,425,783 D426G unknown Het
Zfp622 A G 15: 25,987,200 N308S probably damaging Het
Other mutations in Gpr149
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00330:Gpr149 APN 3 62530673 missense probably damaging 1.00
IGL01339:Gpr149 APN 3 62604297 missense probably damaging 1.00
IGL01399:Gpr149 APN 3 62604431 missense probably damaging 1.00
IGL01954:Gpr149 APN 3 62530927 missense probably benign 0.36
IGL02218:Gpr149 APN 3 62530531 utr 3 prime probably benign
IGL02592:Gpr149 APN 3 62603810 missense possibly damaging 0.75
IGL03393:Gpr149 APN 3 62603945 missense probably benign 0.15
R0578:Gpr149 UTSW 3 62602689 missense possibly damaging 0.81
R1173:Gpr149 UTSW 3 62604467 missense probably damaging 1.00
R1174:Gpr149 UTSW 3 62604467 missense probably damaging 1.00
R1175:Gpr149 UTSW 3 62604467 missense probably damaging 1.00
R1432:Gpr149 UTSW 3 62531018 missense probably damaging 1.00
R1484:Gpr149 UTSW 3 62595171 missense probably benign 0.00
R1972:Gpr149 UTSW 3 62530795 missense probably benign 0.39
R1973:Gpr149 UTSW 3 62530795 missense probably benign 0.39
R2180:Gpr149 UTSW 3 62604068 missense probably damaging 1.00
R2241:Gpr149 UTSW 3 62604053 missense probably benign 0.00
R3118:Gpr149 UTSW 3 62595022 missense probably benign 0.00
R3547:Gpr149 UTSW 3 62595128 missense probably benign 0.01
R3548:Gpr149 UTSW 3 62595128 missense probably benign 0.01
R4206:Gpr149 UTSW 3 62604503 missense possibly damaging 0.92
R4332:Gpr149 UTSW 3 62604373 missense possibly damaging 0.93
R4531:Gpr149 UTSW 3 62602678 missense probably benign 0.00
R4557:Gpr149 UTSW 3 62530870 missense probably damaging 1.00
R4557:Gpr149 UTSW 3 62604497 missense probably benign 0.02
R4593:Gpr149 UTSW 3 62602730 intron probably benign
R5397:Gpr149 UTSW 3 62530805 missense probably damaging 1.00
R6592:Gpr149 UTSW 3 62530540 missense probably benign 0.02
R6642:Gpr149 UTSW 3 62530574 missense probably damaging 1.00
R6845:Gpr149 UTSW 3 62604521 missense possibly damaging 0.58
R7303:Gpr149 UTSW 3 62595070 missense possibly damaging 0.59
Posted On2015-04-16