Incidental Mutation 'IGL02327:Wars1'
| ID |
288544 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Wars1
|
| Ensembl Gene |
ENSMUSG00000021266 |
| Gene Name |
tryptophanyl-tRNA synthetase1 |
| Synonyms |
Wars |
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
IGL02327
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
12 |
| Chromosomal Location |
108825956-108860095 bp(-) (GRCm39) |
| Type of Mutation |
critical splice acceptor site |
| DNA Base Change (assembly) |
T to A
at 108832227 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125320
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000109848]
[ENSMUST00000109848]
[ENSMUST00000109848]
[ENSMUST00000109848]
[ENSMUST00000160477]
[ENSMUST00000161154]
[ENSMUST00000161154]
[ENSMUST00000161154]
[ENSMUST00000161154]
[ENSMUST00000161410]
[ENSMUST00000161410]
[ENSMUST00000161410]
[ENSMUST00000161410]
|
| AlphaFold |
P32921 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000109848
|
| SMART Domains |
Protein: ENSMUSP00000105474
Gene: ENSMUSG00000021266
| Domain | Start | End | E-Value | Type |
|---|
|
WHEP-TRS
|
16 |
72 |
3.01e-23 |
SMART |
|
Pfam:tRNA-synt_1b
|
155 |
447 |
5.8e-25 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000109848
|
| SMART Domains |
Protein: ENSMUSP00000105474
Gene: ENSMUSG00000021266
| Domain | Start | End | E-Value | Type |
|---|
|
WHEP-TRS
|
16 |
72 |
3.01e-23 |
SMART |
|
Pfam:tRNA-synt_1b
|
155 |
447 |
5.8e-25 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000109848
|
| SMART Domains |
Protein: ENSMUSP00000105474
Gene: ENSMUSG00000021266
| Domain | Start | End | E-Value | Type |
|---|
|
WHEP-TRS
|
16 |
72 |
3.01e-23 |
SMART |
|
Pfam:tRNA-synt_1b
|
155 |
447 |
5.8e-25 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000109848
|
| SMART Domains |
Protein: ENSMUSP00000105474
Gene: ENSMUSG00000021266
| Domain | Start | End | E-Value | Type |
|---|
|
WHEP-TRS
|
16 |
72 |
3.01e-23 |
SMART |
|
Pfam:tRNA-synt_1b
|
155 |
447 |
5.8e-25 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000157592
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160477
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000161154
|
| SMART Domains |
Protein: ENSMUSP00000124625
Gene: ENSMUSG00000021266
| Domain | Start | End | E-Value | Type |
|---|
|
WHEP-TRS
|
16 |
72 |
3.01e-23 |
SMART |
|
Pfam:tRNA-synt_1b
|
155 |
446 |
1.4e-22 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000161154
|
| SMART Domains |
Protein: ENSMUSP00000124625
Gene: ENSMUSG00000021266
| Domain | Start | End | E-Value | Type |
|---|
|
WHEP-TRS
|
16 |
72 |
3.01e-23 |
SMART |
|
Pfam:tRNA-synt_1b
|
155 |
446 |
1.4e-22 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000161154
|
| SMART Domains |
Protein: ENSMUSP00000124625
Gene: ENSMUSG00000021266
| Domain | Start | End | E-Value | Type |
|---|
|
WHEP-TRS
|
16 |
72 |
3.01e-23 |
SMART |
|
Pfam:tRNA-synt_1b
|
155 |
446 |
1.4e-22 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000161154
|
| SMART Domains |
Protein: ENSMUSP00000124625
Gene: ENSMUSG00000021266
| Domain | Start | End | E-Value | Type |
|---|
|
WHEP-TRS
|
16 |
72 |
3.01e-23 |
SMART |
|
Pfam:tRNA-synt_1b
|
155 |
446 |
1.4e-22 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000161410
|
| SMART Domains |
Protein: ENSMUSP00000125320
Gene: ENSMUSG00000021266
| Domain | Start | End | E-Value | Type |
|---|
|
WHEP-TRS
|
16 |
72 |
3.01e-23 |
SMART |
|
Pfam:tRNA-synt_1b
|
155 |
447 |
5.8e-25 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000161410
|
| SMART Domains |
Protein: ENSMUSP00000125320
Gene: ENSMUSG00000021266
| Domain | Start | End | E-Value | Type |
|---|
|
WHEP-TRS
|
16 |
72 |
3.01e-23 |
SMART |
|
Pfam:tRNA-synt_1b
|
155 |
447 |
5.8e-25 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000161410
|
| SMART Domains |
Protein: ENSMUSP00000125320
Gene: ENSMUSG00000021266
| Domain | Start | End | E-Value | Type |
|---|
|
WHEP-TRS
|
16 |
72 |
3.01e-23 |
SMART |
|
Pfam:tRNA-synt_1b
|
155 |
447 |
5.8e-25 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000161410
|
| SMART Domains |
Protein: ENSMUSP00000125320
Gene: ENSMUSG00000021266
| Domain | Start | End | E-Value | Type |
|---|
|
WHEP-TRS
|
16 |
72 |
3.01e-23 |
SMART |
|
Pfam:tRNA-synt_1b
|
155 |
447 |
5.8e-25 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162952
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 40 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ankrd9 |
A |
T |
12: 110,943,849 (GRCm39) |
C29S |
probably damaging |
Het |
| Ccdc66 |
G |
A |
14: 27,215,343 (GRCm39) |
A399V |
probably damaging |
Het |
| Ccl12 |
A |
G |
11: 81,993,948 (GRCm39) |
I68M |
possibly damaging |
Het |
| Cd244a |
T |
C |
1: 171,386,909 (GRCm39) |
V6A |
probably benign |
Het |
| Cfap97 |
T |
A |
8: 46,623,179 (GRCm39) |
S190T |
probably damaging |
Het |
| Chic2 |
G |
T |
5: 75,187,741 (GRCm39) |
C106* |
probably null |
Het |
| Ctdsp2 |
G |
A |
10: 126,832,251 (GRCm39) |
D237N |
probably benign |
Het |
| Cyp2a22 |
A |
T |
7: 26,634,206 (GRCm39) |
M316K |
probably damaging |
Het |
| Cyp3a25 |
A |
G |
5: 145,923,731 (GRCm39) |
F304S |
possibly damaging |
Het |
| Ddc |
A |
T |
11: 11,813,739 (GRCm39) |
V209D |
probably damaging |
Het |
| Dhx16 |
A |
G |
17: 36,194,717 (GRCm39) |
K446R |
probably benign |
Het |
| Fgd3 |
T |
C |
13: 49,439,274 (GRCm39) |
K241E |
probably damaging |
Het |
| Hps1 |
G |
T |
19: 42,744,784 (GRCm39) |
|
probably benign |
Het |
| Inpp4b |
C |
T |
8: 82,768,591 (GRCm39) |
T700I |
probably benign |
Het |
| Kremen2 |
T |
A |
17: 23,962,543 (GRCm39) |
M157L |
probably benign |
Het |
| Lrwd1 |
T |
C |
5: 136,152,318 (GRCm39) |
Y582C |
probably damaging |
Het |
| Macf1 |
T |
A |
4: 123,365,523 (GRCm39) |
R1514S |
probably benign |
Het |
| Mex3c |
T |
A |
18: 73,723,781 (GRCm39) |
C625S |
probably damaging |
Het |
| Mical1 |
G |
A |
10: 41,362,660 (GRCm39) |
E932K |
possibly damaging |
Het |
| Ncf2 |
A |
T |
1: 152,692,744 (GRCm39) |
Y87F |
possibly damaging |
Het |
| Neo1 |
T |
C |
9: 58,810,371 (GRCm39) |
T1027A |
probably benign |
Het |
| Nfkbib |
G |
T |
7: 28,458,568 (GRCm39) |
P347Q |
probably benign |
Het |
| Nr1h2 |
G |
A |
7: 44,200,924 (GRCm39) |
|
probably benign |
Het |
| Or1e25 |
A |
T |
11: 73,493,981 (GRCm39) |
T192S |
probably damaging |
Het |
| Or2t43 |
T |
A |
11: 58,457,761 (GRCm39) |
R137W |
probably damaging |
Het |
| Or9m2 |
A |
T |
2: 87,820,601 (GRCm39) |
I49F |
probably damaging |
Het |
| Oxct1 |
A |
G |
15: 4,066,571 (GRCm39) |
|
probably null |
Het |
| Pak1ip1 |
T |
G |
13: 41,165,893 (GRCm39) |
N308K |
probably benign |
Het |
| Prpf38a |
T |
C |
4: 108,425,607 (GRCm39) |
R224G |
unknown |
Het |
| Scfd1 |
T |
C |
12: 51,436,100 (GRCm39) |
V83A |
possibly damaging |
Het |
| Tmem131 |
C |
T |
1: 36,838,103 (GRCm39) |
G1545D |
probably damaging |
Het |
| Trav13n-4 |
A |
T |
14: 53,601,567 (GRCm39) |
|
probably benign |
Het |
| Ttc3 |
A |
G |
16: 94,248,967 (GRCm39) |
D1155G |
probably damaging |
Het |
| Unc80 |
G |
A |
1: 66,680,832 (GRCm39) |
V2143I |
probably benign |
Het |
| Vmn2r16 |
T |
C |
5: 109,487,987 (GRCm39) |
Y287H |
probably benign |
Het |
| Vmn2r59 |
A |
G |
7: 41,661,655 (GRCm39) |
V720A |
probably benign |
Het |
| Wdcp |
A |
G |
12: 4,901,115 (GRCm39) |
K324E |
possibly damaging |
Het |
| Wdfy3 |
A |
T |
5: 102,036,058 (GRCm39) |
L2105H |
probably damaging |
Het |
| Xirp2 |
A |
T |
2: 67,340,444 (GRCm39) |
D895V |
probably damaging |
Het |
| Zscan10 |
A |
T |
17: 23,826,546 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Wars1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01961:Wars1
|
APN |
12 |
108,832,096 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02864:Wars1
|
APN |
12 |
108,848,791 (GRCm39) |
missense |
probably benign |
|
|
IGL02962:Wars1
|
APN |
12 |
108,841,706 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0271:Wars1
|
UTSW |
12 |
108,841,119 (GRCm39) |
missense |
probably benign |
|
|
R0485:Wars1
|
UTSW |
12 |
108,841,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0669:Wars1
|
UTSW |
12 |
108,831,944 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1144:Wars1
|
UTSW |
12 |
108,854,291 (GRCm39) |
nonsense |
probably null |
|
|
R1581:Wars1
|
UTSW |
12 |
108,841,635 (GRCm39) |
nonsense |
probably null |
|
|
R1730:Wars1
|
UTSW |
12 |
108,841,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1783:Wars1
|
UTSW |
12 |
108,841,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1990:Wars1
|
UTSW |
12 |
108,854,359 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5382:Wars1
|
UTSW |
12 |
108,848,706 (GRCm39) |
missense |
probably benign |
|
|
R5703:Wars1
|
UTSW |
12 |
108,841,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6299:Wars1
|
UTSW |
12 |
108,827,309 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7186:Wars1
|
UTSW |
12 |
108,846,982 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7508:Wars1
|
UTSW |
12 |
108,848,801 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7919:Wars1
|
UTSW |
12 |
108,847,030 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8530:Wars1
|
UTSW |
12 |
108,848,818 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9132:Wars1
|
UTSW |
12 |
108,827,199 (GRCm39) |
missense |
probably benign |
0.41 |
|
| Posted On |
2015-04-16 |
Incidental Mutation