Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02385:Dus4l'

291531

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dus4l

Ensembl Gene

ENSMUSG00000020648

Gene Name

dihydrouridine synthase 4 like

Synonyms

2700089B10Rik, 2310069P03Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.174) question?

Stock #

IGL02385

Quality Score

Status

Chromosome

Chromosomal Location

31690049-31704825 bp(-) (GRCm39)

Type of Mutation

utr 3 prime

DNA Base Change (assembly)

A to G at 31690674 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000020977 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000020977]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000020977

SMART Domains

Protein: ENSMUSP00000020977
Gene: ENSMUSG00000020648

Domain	Start	End	E-Value	Type
Pfam:Dus	30	312	3.3e-76	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700049A03Rik	T	A	12: 71,201,630 (GRCm39)	D351E	probably damaging	Het
Adad2	A	G	8: 120,341,773 (GRCm39)		probably benign	Het
Adamts8	A	G	9: 30,873,026 (GRCm39)	N744D	probably benign	Het
Atad5	C	T	11: 79,985,453 (GRCm39)	T180I	probably benign	Het
Atp2a3	C	A	11: 72,866,165 (GRCm39)	H262N	probably benign	Het
Bcl9	A	T	3: 97,116,594 (GRCm39)	I700K	probably benign	Het
Bcr	T	C	10: 74,981,235 (GRCm39)	S685P	probably damaging	Het
Cd36	A	G	5: 18,019,717 (GRCm39)	V128A	probably benign	Het
Cfap20dc	A	G	14: 8,510,920 (GRCm38)	V498A	possibly damaging	Het
Chd2	T	C	7: 73,085,570 (GRCm39)	Y1688C	probably damaging	Het
Csmd1	A	G	8: 15,953,275 (GRCm39)	V3402A	probably benign	Het
Dsg3	T	C	18: 20,660,771 (GRCm39)	V370A	probably damaging	Het
Fcrlb	A	G	1: 170,735,168 (GRCm39)	S320P	probably damaging	Het
Fer1l4	T	C	2: 155,887,348 (GRCm39)	D616G	probably benign	Het
Fxr2	C	T	11: 69,543,095 (GRCm39)	R631C	possibly damaging	Het
Gltpd2	T	A	11: 70,410,822 (GRCm39)	F152I	probably damaging	Het
Gpt2	T	A	8: 86,242,782 (GRCm39)		probably null	Het
Hsd3b6	A	T	3: 98,713,888 (GRCm39)	I137K	possibly damaging	Het
Kcna6	A	G	6: 126,715,917 (GRCm39)	V324A	probably benign	Het
Kcnu1	C	T	8: 26,422,298 (GRCm39)	L188F	probably damaging	Het
Kdm1b	A	G	13: 47,221,982 (GRCm39)	I474V	possibly damaging	Het
Kifap3	C	T	1: 163,693,013 (GRCm39)	Q602*	probably null	Het
Lrp4	T	A	2: 91,305,065 (GRCm39)	C231S	possibly damaging	Het
Lrrc63	T	C	14: 75,323,640 (GRCm39)	D528G	probably benign	Het
Nosip	C	A	7: 44,726,156 (GRCm39)	R240S	possibly damaging	Het
Or11g26	T	C	14: 50,752,900 (GRCm39)	S80P	probably damaging	Het
Or4f57	G	A	2: 111,790,603 (GRCm39)	P272S	probably benign	Het
Or4k41	A	G	2: 111,279,695 (GRCm39)	D70G	probably damaging	Het
Orc5	A	T	5: 22,731,438 (GRCm39)	D231E	probably damaging	Het
Poli	A	T	18: 70,659,645 (GRCm39)	M62K	possibly damaging	Het
Ppp1r13b	A	C	12: 111,801,477 (GRCm39)	S402R	probably damaging	Het
Prl3b1	T	C	13: 27,433,366 (GRCm39)	S174P	possibly damaging	Het
Ptpra	T	C	2: 130,382,393 (GRCm39)		probably benign	Het
Sfpq	T	A	4: 126,919,929 (GRCm39)		probably null	Het
Sh3bp1	T	A	15: 78,790,088 (GRCm39)		probably benign	Het
Slc7a2	T	G	8: 41,352,048 (GRCm39)	V37G	probably damaging	Het
Smc1a	A	T	X: 150,820,655 (GRCm39)	E794D	possibly damaging	Het
Sox6	T	C	7: 115,149,274 (GRCm39)	R366G	possibly damaging	Het
Spaca7	A	G	8: 12,636,498 (GRCm39)	N108S	possibly damaging	Het
Spon1	T	G	7: 113,365,567 (GRCm39)	M1R	probably null	Het
Sult6b2	T	C	6: 142,747,498 (GRCm39)	R84G	probably benign	Het
Syt2	A	G	1: 134,673,553 (GRCm39)	N299S	probably benign	Het
Syvn1	T	C	19: 6,098,570 (GRCm39)	V104A	probably damaging	Het
Tbpl1	A	G	10: 22,583,568 (GRCm39)	L134P	probably damaging	Het
Tex11	A	T	X: 99,920,135 (GRCm39)		probably benign	Het
Tnfrsf21	A	G	17: 43,350,942 (GRCm39)	S369G	probably damaging	Het
Tram1l1	T	C	3: 124,115,707 (GRCm39)	V289A	probably benign	Het
Ttyh3	A	T	5: 140,619,060 (GRCm39)	F277L	probably benign	Het
Vmn2r17	T	G	5: 109,582,247 (GRCm39)	N545K	probably damaging	Het
Wdr20	A	T	12: 110,759,657 (GRCm39)	H181L	probably benign	Het
Zscan20	A	G	4: 128,498,392 (GRCm39)	M2T	possibly damaging	Het

Other mutations in Dus4l

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00429:Dus4l	APN	12	31,691,668 (GRCm39)	missense	probably benign	0.27
IGL01299:Dus4l	APN	12	31,690,823 (GRCm39)	missense	probably benign
IGL01443:Dus4l	APN	12	31,702,409 (GRCm39)	unclassified	probably benign
IGL01796:Dus4l	APN	12	31,692,794 (GRCm39)	missense	probably benign	0.01
IGL02234:Dus4l	APN	12	31,691,495 (GRCm39)	splice site	probably benign
R0483:Dus4l	UTSW	12	31,691,656 (GRCm39)	missense	possibly damaging	0.91
R1432:Dus4l	UTSW	12	31,698,770 (GRCm39)	missense	probably benign	0.03
R1514:Dus4l	UTSW	12	31,690,938 (GRCm39)	missense	probably damaging	1.00
R1880:Dus4l	UTSW	12	31,690,869 (GRCm39)	missense	probably benign	0.00
R4362:Dus4l	UTSW	12	31,698,827 (GRCm39)	missense	probably damaging	1.00
R5425:Dus4l	UTSW	12	31,690,807 (GRCm39)	missense	probably damaging	1.00
R5568:Dus4l	UTSW	12	31,696,712 (GRCm39)	missense	probably damaging	1.00
R7188:Dus4l	UTSW	12	31,696,714 (GRCm39)	missense	probably damaging	1.00
R8184:Dus4l	UTSW	12	31,690,817 (GRCm39)	missense	probably damaging	1.00
R8900:Dus4l	UTSW	12	31,690,692 (GRCm39)	missense	possibly damaging	0.51
R9696:Dus4l	UTSW	12	31,696,647 (GRCm39)	missense	probably damaging	0.97
R9801:Dus4l	UTSW	12	31,698,827 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-04-16