Incidental Mutation 'IGL02478:Tas2r122'
ID295065
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r122
Ensembl Gene ENSMUSG00000078280
Gene Nametaste receptor, type 2, member 122
SynonymsTas2r22, T2R22, mGR22
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.019) question?
Stock #IGL02478
Quality Score
Status
Chromosome6
Chromosomal Location132710999-132711928 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 132711615 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 105 (V105A)
Ref Sequence ENSEMBL: ENSMUSP00000100699 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105077]
Predicted Effect possibly damaging
Transcript: ENSMUST00000105077
AA Change: V105A

PolyPhen 2 Score 0.814 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000100699
Gene: ENSMUSG00000078280
AA Change: V105A

DomainStartEndE-ValueType
Pfam:TAS2R 1 302 2.3e-73 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b C A 5: 8,806,018 A42E probably damaging Het
Agmo T A 12: 37,401,986 F247L probably damaging Het
Arap1 C A 7: 101,400,125 probably null Het
Arid1a T C 4: 133,681,274 D1974G unknown Het
Asxl3 C T 18: 22,523,013 A1360V possibly damaging Het
Celsr1 T A 15: 85,941,136 T1599S possibly damaging Het
Chrdl2 T C 7: 100,020,983 probably null Het
Csmd3 T C 15: 47,838,398 probably benign Het
Dis3l C T 9: 64,314,773 E452K probably benign Het
Dnajc2 A T 5: 21,776,790 H45Q probably damaging Het
Eps8 G A 6: 137,522,842 P213L probably benign Het
Erbb3 T A 10: 128,571,358 R978* probably null Het
Exoc2 A T 13: 30,927,420 C142S probably benign Het
Fam184b T C 5: 45,537,697 E735G probably damaging Het
Fam208b T C 13: 3,574,661 E1763G probably benign Het
Fancm T C 12: 65,077,090 V174A probably damaging Het
Fat4 T C 3: 38,888,215 L419P probably damaging Het
Fsip2 G T 2: 82,984,392 V3490L probably benign Het
Ftcd A T 10: 76,581,421 R255* probably null Het
Galc T C 12: 98,213,132 N506S possibly damaging Het
Gm20441 G T 10: 75,772,810 A26E probably damaging Het
Gm21969 T G 4: 139,640,688 probably null Het
Hspb11 T A 4: 107,275,252 S79T probably benign Het
Ifitm3 T A 7: 141,009,874 M89L possibly damaging Het
Inmt T C 6: 55,173,370 E94G probably damaging Het
Insrr G A 3: 87,809,412 G649D probably benign Het
Ivd T C 2: 118,862,091 L24P probably benign Het
Kcnc1 A G 7: 46,435,169 N506D probably benign Het
Krt39 T A 11: 99,520,897 D121V probably benign Het
Lcp1 A G 14: 75,224,096 I510V probably benign Het
Mkx C T 18: 7,002,418 V43M probably damaging Het
Mmp2 A G 8: 92,852,607 N108S possibly damaging Het
Mob1b T C 5: 88,756,088 probably benign Het
Morc3 A G 16: 93,864,956 probably benign Het
Myh13 T G 11: 67,369,378 S1881A probably benign Het
Nalcn T C 14: 123,321,305 E843G probably benign Het
Ngef A G 1: 87,480,579 probably benign Het
Olfr293 T A 7: 86,664,136 I158N probably damaging Het
Osm A G 11: 4,239,507 Y97C probably damaging Het
Pclo T A 5: 14,766,778 L4556Q unknown Het
Pcyox1l T C 18: 61,697,709 D364G probably benign Het
Plekha6 T A 1: 133,283,293 V467E probably benign Het
Qrsl1 A T 10: 43,882,162 S312T probably damaging Het
Ripk1 T A 13: 34,010,589 L70Q probably damaging Het
Rnaseh1 A T 12: 28,655,663 Y162F probably damaging Het
Ror2 T A 13: 53,121,667 T195S probably damaging Het
Sh3bp2 T C 5: 34,551,662 L33P probably damaging Het
Skil T A 3: 31,097,819 C163* probably null Het
Slc25a37 A T 14: 69,249,434 N133K probably benign Het
Slitrk3 A C 3: 73,050,713 V242G probably damaging Het
Sra1 A G 18: 36,668,792 S82P probably benign Het
Synj2 A G 17: 6,037,924 N1417D probably benign Het
Ttc21b T C 2: 66,188,280 N1261S probably benign Het
Vmn2r69 A G 7: 85,406,681 S750P probably damaging Het
Wdr95 A G 5: 149,596,321 T568A probably benign Het
Zfp319 T A 8: 95,329,093 I161F possibly damaging Het
Other mutations in Tas2r122
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01712:Tas2r122 APN 6 132711762 missense possibly damaging 0.87
IGL02605:Tas2r122 APN 6 132711609 missense probably damaging 0.99
IGL02646:Tas2r122 APN 6 132711790 missense probably damaging 1.00
IGL02716:Tas2r122 APN 6 132711264 missense probably damaging 1.00
R0318:Tas2r122 UTSW 6 132711832 missense possibly damaging 0.90
R0462:Tas2r122 UTSW 6 132711178 missense probably benign 0.06
R0532:Tas2r122 UTSW 6 132711828 missense possibly damaging 0.94
R0538:Tas2r122 UTSW 6 132711815 missense probably benign 0.06
R0570:Tas2r122 UTSW 6 132711811 missense probably damaging 1.00
R1863:Tas2r122 UTSW 6 132711102 nonsense probably null
R1966:Tas2r122 UTSW 6 132711194 nonsense probably null
R2001:Tas2r122 UTSW 6 132711622 missense possibly damaging 0.91
R3500:Tas2r122 UTSW 6 132711560 missense probably damaging 1.00
R3871:Tas2r122 UTSW 6 132711580 missense probably benign 0.00
R4174:Tas2r122 UTSW 6 132711876 missense probably damaging 0.96
R5533:Tas2r122 UTSW 6 132711430 missense probably damaging 1.00
R5567:Tas2r122 UTSW 6 132711372 missense probably benign 0.28
R6455:Tas2r122 UTSW 6 132711663 nonsense probably null
R6716:Tas2r122 UTSW 6 132711897 missense probably damaging 0.98
Posted On2015-04-16