Incidental Mutation 'IGL02751:Vmn1r81'
ID 306287
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r81
Ensembl Gene ENSMUSG00000115027
Gene Name vomeronasal 1 receptor 81
Synonyms V1rg9
Accession Numbers
Essential gene? Probably essential (E-score: 0.822) question?
Stock # IGL02751
Quality Score
Status
Chromosome 7
Chromosomal Location 11993686-11994606 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 11994374 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 78 (L78Q)
Ref Sequence ENSEMBL: ENSMUSP00000153767 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086232] [ENSMUST00000227080] [ENSMUST00000227973] [ENSMUST00000228482] [ENSMUST00000228764]
AlphaFold A0A2I3BPG7
Predicted Effect probably damaging
Transcript: ENSMUST00000086232
AA Change: L78Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000083409
Gene: ENSMUSG00000115027
AA Change: L78Q

DomainStartEndE-ValueType
Pfam:TAS2R 3 301 5.4e-12 PFAM
Pfam:V1R 34 299 6.6e-31 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000227080
AA Change: L78Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000227973
AA Change: L78Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000228482
AA Change: L78Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000228764
AA Change: L78Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adra1a A T 14: 66,964,981 (GRCm39) I324F possibly damaging Het
Ago2 G A 15: 73,002,746 (GRCm39) A162V possibly damaging Het
Aox4 G T 1: 58,298,211 (GRCm39) R1059I probably damaging Het
AU021092 C A 16: 5,030,483 (GRCm39) V304L probably damaging Het
Bcs1l T G 1: 74,628,775 (GRCm39) F20V probably damaging Het
Braf T C 6: 39,637,801 (GRCm39) probably benign Het
Cacna1a T C 8: 85,296,581 (GRCm39) C1200R probably damaging Het
Ccdc116 T A 16: 16,959,836 (GRCm39) R284S probably benign Het
Cntnap5a T G 1: 116,112,187 (GRCm39) probably null Het
Col12a1 A T 9: 79,521,141 (GRCm39) probably benign Het
Cpa4 T A 6: 30,581,739 (GRCm39) Y229N probably damaging Het
Fbp1 A C 13: 63,022,957 (GRCm39) probably null Het
Gimap3 A T 6: 48,742,172 (GRCm39) W253R probably benign Het
Gm1330 G A 2: 148,832,393 (GRCm39) probably benign Het
Gm4841 A G 18: 60,404,093 (GRCm39) probably benign Het
Grip1 A G 10: 119,814,482 (GRCm39) T338A probably benign Het
Hmg20b A T 10: 81,182,385 (GRCm39) probably benign Het
Hnrnpdl A G 5: 100,185,833 (GRCm39) F151L probably damaging Het
Klhl30 T A 1: 91,281,821 (GRCm39) F141I probably damaging Het
Lamc3 T A 2: 31,810,716 (GRCm39) F862Y probably benign Het
Lap3 T C 5: 45,662,138 (GRCm39) C313R probably damaging Het
Lrp2 T C 2: 69,363,806 (GRCm39) T344A possibly damaging Het
Mga A G 2: 119,778,251 (GRCm39) E2023G possibly damaging Het
Mical2 A T 7: 111,931,243 (GRCm39) K735N probably benign Het
Muc15 A G 2: 110,562,118 (GRCm39) T185A probably benign Het
Or12d17 T C 17: 37,777,306 (GRCm39) C70R probably damaging Het
Osbp2 T C 11: 3,813,434 (GRCm39) K145R probably benign Het
Pde1c T C 6: 56,158,673 (GRCm39) T52A probably damaging Het
Pidd1 A G 7: 141,019,076 (GRCm39) S802P possibly damaging Het
Pip5k1c C A 10: 81,153,155 (GRCm39) probably null Het
Prep T A 10: 44,991,282 (GRCm39) I316N probably damaging Het
Prl3d2 G A 13: 27,310,014 (GRCm39) probably null Het
Pygo1 A T 9: 72,852,319 (GRCm39) I169F probably benign Het
Rnf10 G T 5: 115,380,725 (GRCm39) A716E probably benign Het
Rtn4 G A 11: 29,656,409 (GRCm39) probably null Het
Ryr1 A T 7: 28,778,199 (GRCm39) V2099E probably damaging Het
Slc48a1 G A 15: 97,687,961 (GRCm39) probably benign Het
Spag17 T A 3: 99,918,110 (GRCm39) Y364* probably null Het
Syt3 A T 7: 44,035,486 (GRCm39) D31V possibly damaging Het
Tango2 G T 16: 18,125,857 (GRCm39) P143H probably benign Het
Tas2r104 A G 6: 131,662,107 (GRCm39) S201P probably damaging Het
Tas2r107 G A 6: 131,636,447 (GRCm39) L201F probably damaging Het
Vmn2r18 T A 5: 151,508,072 (GRCm39) T351S probably benign Het
Other mutations in Vmn1r81
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02026:Vmn1r81 APN 7 11,994,432 (GRCm39) missense probably damaging 1.00
IGL02086:Vmn1r81 APN 7 11,993,792 (GRCm39) missense possibly damaging 0.82
IGL02879:Vmn1r81 APN 7 11,994,319 (GRCm39) missense probably benign 0.20
IGL03358:Vmn1r81 APN 7 11,994,232 (GRCm39) missense possibly damaging 0.57
PIT4305001:Vmn1r81 UTSW 7 11,994,590 (GRCm39) missense probably benign 0.01
R0359:Vmn1r81 UTSW 7 11,993,877 (GRCm39) missense probably damaging 1.00
R1615:Vmn1r81 UTSW 7 11,994,441 (GRCm39) missense probably damaging 1.00
R1938:Vmn1r81 UTSW 7 11,994,589 (GRCm39) missense possibly damaging 0.67
R2967:Vmn1r81 UTSW 7 11,993,964 (GRCm39) missense probably damaging 0.99
R2983:Vmn1r81 UTSW 7 11,994,596 (GRCm39) missense probably benign 0.02
R4549:Vmn1r81 UTSW 7 11,993,749 (GRCm39) missense probably damaging 0.99
R5099:Vmn1r81 UTSW 7 11,994,248 (GRCm39) missense possibly damaging 0.86
R5326:Vmn1r81 UTSW 7 11,994,034 (GRCm39) missense probably damaging 1.00
R5542:Vmn1r81 UTSW 7 11,994,034 (GRCm39) missense probably damaging 1.00
R6010:Vmn1r81 UTSW 7 11,994,349 (GRCm39) missense possibly damaging 0.88
R6630:Vmn1r81 UTSW 7 11,994,584 (GRCm39) nonsense probably null
R6724:Vmn1r81 UTSW 7 11,994,599 (GRCm39) missense probably damaging 1.00
R6754:Vmn1r81 UTSW 7 11,993,774 (GRCm39) missense probably damaging 0.98
R8198:Vmn1r81 UTSW 7 11,993,882 (GRCm39) missense possibly damaging 0.64
R9719:Vmn1r81 UTSW 7 11,994,449 (GRCm39) missense probably damaging 1.00
R9790:Vmn1r81 UTSW 7 11,994,113 (GRCm39) missense probably benign 0.15
R9791:Vmn1r81 UTSW 7 11,994,113 (GRCm39) missense probably benign 0.15
Posted On 2015-04-16